Prediction of 7-year's conversion from subjective cognitive decline to mild cognitive impairment

Ling Yue, Dan Hu, Han Zhang, Junhao Wen, Ye Wu, Wei Li, Lin Sun, Xia Li, Jinghua Wang, Guanjun Li, Tao Wang, Dinggang Shen, Shifu Xiao

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Subjective cognitive decline (SCD) is a high-risk yet less understood status before developing Alzheimer's disease (AD). This work included 76 SCD individuals with two (baseline and 7 years later) neuropsychological evaluations and a baseline T1-weighted structural MRI. A machine learning-based model was trained based on 198 baseline neuroimaging (morphometric) features and a battery of 25 clinical measurements to discriminate 24 progressive SCDs who converted to mild cognitive impairment (MCI) at follow-up from 52 stable SCDs. The SCD progression was satisfactorily predicted with the combined features. A history of stroke, a low education level, a low baseline MoCA score, a shrunk left amygdala, and enlarged white matter at the banks of the right superior temporal sulcus were found to favor the progression. This is to date the largest retrospective study of SCD-to-MCI conversion with the longest follow-up, suggesting predictable far-future cognitive decline for the risky populations with baseline measures only. These findings provide valuable knowledge to the future neuropathological studies of AD in its prodromal phase.

Original languageEnglish
Pages (from-to)192-203
Number of pages12
JournalHuman Brain Mapping
Issue number1
Publication statusPublished - 2021 Jan


  • MRI
  • machine learning
  • prediction
  • subjective cognitive decline

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology


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