Predictive factors for late recurrence in patients with stage T1 clear cell renal cell carcinoma: A multiinstitutional study

Yun Sok Ha, Yong Hyun Park, Seok Ho Kang, Sung Hoo Hong, Tae Kon Hwang, Seok Soo Byun, Yong June Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: The purpose of this study was to identify predictive factors for late recurrence in Korean patients with stage T1 clear cell renal cell carcinoma (RCC) more than 5 years after treatment with radical nephrectomy (RN) or partial nephrectomy (PN). Patients and Methods: Between 1999 and 2011, 3567 patients with RCC underwent RN or PN at 5 institutions in Korea. Of these, 423 patients with pathologically confirmed stage T1 clear cell RCC remained free of disease for at least 5 years. To determine the pathologic and clinical factors that influenced late recurrence, univariate and multivariate analyses using the Cox proportional hazards model were performed. Recurrence-free survival curves were estimated by using the Kaplan-Meier method. Results: During a median follow-up period of 83.9 months (range 60.0-156.4 months), late recurrence was observed in 14 of the 423 (3.3%) patients. Univariate and multivariate analyses revealed that symptoms at diagnosis and pathologic T stage were independent predictive factors for late recurrence. Patients with symptoms at diagnosis or stage T1b disease had a significantly shorter time to late recurrence than did those who were asymptomatic or had stage T1a disease (log-rank test P =.027 and P =.034, respectively). Conclusions: Late recurrence in stage T1 clear cell RCC is a relatively rare event. Predictive factors for late recurrence were identified in the present study. Careful long-term follow-up is necessary, especially in patients who have symptoms at diagnosis or stage T1b tumors, even if they have been free of disease for more than 5 years.

Original languageEnglish
Pages (from-to)51-55
Number of pages5
JournalClinical Genitourinary Cancer
Volume11
Issue number1
DOIs
Publication statusPublished - 2013 Mar 1

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Renal Cell Carcinoma
Recurrence
Nephrectomy
Multivariate Analysis
Korea
Proportional Hazards Models
Survival
Neoplasms

Keywords

  • Multiinstitutional study
  • Prognosis
  • Recurrence
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Predictive factors for late recurrence in patients with stage T1 clear cell renal cell carcinoma : A multiinstitutional study. / Ha, Yun Sok; Park, Yong Hyun; Kang, Seok Ho; Hong, Sung Hoo; Hwang, Tae Kon; Byun, Seok Soo; Kim, Yong June.

In: Clinical Genitourinary Cancer, Vol. 11, No. 1, 01.03.2013, p. 51-55.

Research output: Contribution to journalArticle

Ha, Yun Sok ; Park, Yong Hyun ; Kang, Seok Ho ; Hong, Sung Hoo ; Hwang, Tae Kon ; Byun, Seok Soo ; Kim, Yong June. / Predictive factors for late recurrence in patients with stage T1 clear cell renal cell carcinoma : A multiinstitutional study. In: Clinical Genitourinary Cancer. 2013 ; Vol. 11, No. 1. pp. 51-55.
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abstract = "Background: The purpose of this study was to identify predictive factors for late recurrence in Korean patients with stage T1 clear cell renal cell carcinoma (RCC) more than 5 years after treatment with radical nephrectomy (RN) or partial nephrectomy (PN). Patients and Methods: Between 1999 and 2011, 3567 patients with RCC underwent RN or PN at 5 institutions in Korea. Of these, 423 patients with pathologically confirmed stage T1 clear cell RCC remained free of disease for at least 5 years. To determine the pathologic and clinical factors that influenced late recurrence, univariate and multivariate analyses using the Cox proportional hazards model were performed. Recurrence-free survival curves were estimated by using the Kaplan-Meier method. Results: During a median follow-up period of 83.9 months (range 60.0-156.4 months), late recurrence was observed in 14 of the 423 (3.3{\%}) patients. Univariate and multivariate analyses revealed that symptoms at diagnosis and pathologic T stage were independent predictive factors for late recurrence. Patients with symptoms at diagnosis or stage T1b disease had a significantly shorter time to late recurrence than did those who were asymptomatic or had stage T1a disease (log-rank test P =.027 and P =.034, respectively). Conclusions: Late recurrence in stage T1 clear cell RCC is a relatively rare event. Predictive factors for late recurrence were identified in the present study. Careful long-term follow-up is necessary, especially in patients who have symptoms at diagnosis or stage T1b tumors, even if they have been free of disease for more than 5 years.",
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AU - Hwang, Tae Kon

AU - Byun, Seok Soo

AU - Kim, Yong June

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N2 - Background: The purpose of this study was to identify predictive factors for late recurrence in Korean patients with stage T1 clear cell renal cell carcinoma (RCC) more than 5 years after treatment with radical nephrectomy (RN) or partial nephrectomy (PN). Patients and Methods: Between 1999 and 2011, 3567 patients with RCC underwent RN or PN at 5 institutions in Korea. Of these, 423 patients with pathologically confirmed stage T1 clear cell RCC remained free of disease for at least 5 years. To determine the pathologic and clinical factors that influenced late recurrence, univariate and multivariate analyses using the Cox proportional hazards model were performed. Recurrence-free survival curves were estimated by using the Kaplan-Meier method. Results: During a median follow-up period of 83.9 months (range 60.0-156.4 months), late recurrence was observed in 14 of the 423 (3.3%) patients. Univariate and multivariate analyses revealed that symptoms at diagnosis and pathologic T stage were independent predictive factors for late recurrence. Patients with symptoms at diagnosis or stage T1b disease had a significantly shorter time to late recurrence than did those who were asymptomatic or had stage T1a disease (log-rank test P =.027 and P =.034, respectively). Conclusions: Late recurrence in stage T1 clear cell RCC is a relatively rare event. Predictive factors for late recurrence were identified in the present study. Careful long-term follow-up is necessary, especially in patients who have symptoms at diagnosis or stage T1b tumors, even if they have been free of disease for more than 5 years.

AB - Background: The purpose of this study was to identify predictive factors for late recurrence in Korean patients with stage T1 clear cell renal cell carcinoma (RCC) more than 5 years after treatment with radical nephrectomy (RN) or partial nephrectomy (PN). Patients and Methods: Between 1999 and 2011, 3567 patients with RCC underwent RN or PN at 5 institutions in Korea. Of these, 423 patients with pathologically confirmed stage T1 clear cell RCC remained free of disease for at least 5 years. To determine the pathologic and clinical factors that influenced late recurrence, univariate and multivariate analyses using the Cox proportional hazards model were performed. Recurrence-free survival curves were estimated by using the Kaplan-Meier method. Results: During a median follow-up period of 83.9 months (range 60.0-156.4 months), late recurrence was observed in 14 of the 423 (3.3%) patients. Univariate and multivariate analyses revealed that symptoms at diagnosis and pathologic T stage were independent predictive factors for late recurrence. Patients with symptoms at diagnosis or stage T1b disease had a significantly shorter time to late recurrence than did those who were asymptomatic or had stage T1a disease (log-rank test P =.027 and P =.034, respectively). Conclusions: Late recurrence in stage T1 clear cell RCC is a relatively rare event. Predictive factors for late recurrence were identified in the present study. Careful long-term follow-up is necessary, especially in patients who have symptoms at diagnosis or stage T1b tumors, even if they have been free of disease for more than 5 years.

KW - Multiinstitutional study

KW - Prognosis

KW - Recurrence

KW - Renal cell carcinoma

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