Predictive factors for the development of chronic renal insufficiency after renal surgery

A multicenter study

Yong Sun Choi, Yong Hyun Park, Yong June Kim, Seok Ho Kang, Seok Soo Byun, Sung Hoo Hong

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose: To evaluate which factors affecting changes in postoperative renal function after conducting radical nephrectomy or partial nephrectomy. Methods: Data on patients who underwent operations for renal cell carcinoma between 2000 and 2010 at multiple institutions were collected. Patient characteristics including preoperative estimated glomerular filtration rate (EGFR) were investigated, and types of surgery and postoperative results were evaluated. Renal insufficiency was defined as an EGFR <60 ml/min/1.73 m2. Cox proportional hazard regression analysis was used to investigate which factors were associated with chronic renal insufficiency after surgery. Results: A total of 2,454 patients were included for evaluation; 1,502 patients underwent radical nephrectomy, whereas 952 patients underwent partial nephrectomy. The mean follow-up period was 44.48 ± 27.04 months (range, 12-120 months). Factors affecting EGFR were age, diabetes, hypertension, surgical procedure, and preoperative creatinine level (p < 0.001). Factors affecting postoperative renal insufficiency were age, surgical procedure, serum creatinine level, and EGFR. Conclusion: The risk for developing post-nephrectomy renal insufficiency in patients who underwent radical nephrectomy was higher than those who underwent partial nephrectomy. Factors affecting post-nephrectomy renal insufficiency were age, preoperative serum creatinine level, and preoperative EGFR. In addition to radical nephrectomy, patient >58 years with a preoperative serum creatinine >1.03 mg/ml, and EGFR <73 ml/min/1.73 m 2 had a higher probability of developing post-nephrectomy chronic renal insufficiency.

Original languageEnglish
Pages (from-to)681-686
Number of pages6
JournalInternational Urology and Nephrology
Volume46
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

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Nephrectomy
Glomerular Filtration Rate
Chronic Renal Insufficiency
Multicenter Studies
Kidney
Renal Cell Carcinoma
Renal Insufficiency
Creatinine
Serum

Keywords

  • Chronic renal insufficiency
  • Nephrectomy
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Predictive factors for the development of chronic renal insufficiency after renal surgery : A multicenter study. / Choi, Yong Sun; Park, Yong Hyun; Kim, Yong June; Kang, Seok Ho; Byun, Seok Soo; Hong, Sung Hoo.

In: International Urology and Nephrology, Vol. 46, No. 4, 01.01.2014, p. 681-686.

Research output: Contribution to journalArticle

Choi, Yong Sun ; Park, Yong Hyun ; Kim, Yong June ; Kang, Seok Ho ; Byun, Seok Soo ; Hong, Sung Hoo. / Predictive factors for the development of chronic renal insufficiency after renal surgery : A multicenter study. In: International Urology and Nephrology. 2014 ; Vol. 46, No. 4. pp. 681-686.
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