Predictive risk factors for coronary artery abnormalities in Kawasaki disease

Taeyeun Kim, WookSun Choi, Chan Wook Woo, Byung Min Choi, Jung Hwa Lee, Kwang Chul Lee, Chang Sung Son, Joowon Lee

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Clinical characteristics to predict the development of coronary artery abnormalities (CAA) in Kawasaki disease (KD) were assessed by reviewing medical records of patients diagnosed with KD at Korea University Medical Center from March 2001 to February 2005. Of the 285 patients diagnosed with KD, 19 developed CAA (6.7%). Compared with the CAA(-) group, the CAA(+) group had a longer duration of fever after intravenous gamma-globulin (IVGG) injection (2.4±2.9 vs. 1.5±1.2 days, p=0.008) and higher C-reactive protein (CRP)(12.3±7.8 vs. 8.7±7.1 mg/dL, p=0.038). In particular, the CAA(+) group tended to have more than 7 days of fever before IVGG and more than 3 days of fever after IVGG (26.3 vs. 5.3%, p<0.001; 26.3 vs. 6.4%, p=0.002). When the IVGG responsiveness was defined by the presence of defervescence within 3 days after IVGG, IVGG-non-responders showed a higher incidence of CAA (22.7 vs. 5.3%, p=0.002). Non-responders had a longer duration of fever after IVGG (5.5±1.9 vs. 1.2±0.6 days, p<0.001) and a significantly increased CRP, AST, ALT and total bilirubin. Multivariate regression analysis for CAA showed that the only factor significantly associated with the development of CAA was total fever that lasted for longer than 8 days (OR=4.052, 95% CI=1.151-14.263, p=0.0293). Conclusively, the most important predictor of CAA in KD is total duration of fever longer than 8 days. Early identification of IVGG non-responders and active therapeutic intervention for fever in KD cases might decrease the incidence of CAA.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalEuropean Journal of Pediatrics
Volume166
Issue number5
DOIs
Publication statusPublished - 2007 May 1

Fingerprint

Mucocutaneous Lymph Node Syndrome
gamma-Globulins
Coronary Vessels
Fever
C-Reactive Protein
Incidence
Korea
Bilirubin
Medical Records
Multivariate Analysis
Regression Analysis

Keywords

  • Coronary abnormality
  • IVGG-non-responsiveness
  • Kawasaki disease
  • Risk factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Predictive risk factors for coronary artery abnormalities in Kawasaki disease. / Kim, Taeyeun; Choi, WookSun; Woo, Chan Wook; Choi, Byung Min; Lee, Jung Hwa; Lee, Kwang Chul; Son, Chang Sung; Lee, Joowon.

In: European Journal of Pediatrics, Vol. 166, No. 5, 01.05.2007, p. 421-425.

Research output: Contribution to journalArticle

Kim, Taeyeun ; Choi, WookSun ; Woo, Chan Wook ; Choi, Byung Min ; Lee, Jung Hwa ; Lee, Kwang Chul ; Son, Chang Sung ; Lee, Joowon. / Predictive risk factors for coronary artery abnormalities in Kawasaki disease. In: European Journal of Pediatrics. 2007 ; Vol. 166, No. 5. pp. 421-425.
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abstract = "Clinical characteristics to predict the development of coronary artery abnormalities (CAA) in Kawasaki disease (KD) were assessed by reviewing medical records of patients diagnosed with KD at Korea University Medical Center from March 2001 to February 2005. Of the 285 patients diagnosed with KD, 19 developed CAA (6.7{\%}). Compared with the CAA(-) group, the CAA(+) group had a longer duration of fever after intravenous gamma-globulin (IVGG) injection (2.4±2.9 vs. 1.5±1.2 days, p=0.008) and higher C-reactive protein (CRP)(12.3±7.8 vs. 8.7±7.1 mg/dL, p=0.038). In particular, the CAA(+) group tended to have more than 7 days of fever before IVGG and more than 3 days of fever after IVGG (26.3 vs. 5.3{\%}, p<0.001; 26.3 vs. 6.4{\%}, p=0.002). When the IVGG responsiveness was defined by the presence of defervescence within 3 days after IVGG, IVGG-non-responders showed a higher incidence of CAA (22.7 vs. 5.3{\%}, p=0.002). Non-responders had a longer duration of fever after IVGG (5.5±1.9 vs. 1.2±0.6 days, p<0.001) and a significantly increased CRP, AST, ALT and total bilirubin. Multivariate regression analysis for CAA showed that the only factor significantly associated with the development of CAA was total fever that lasted for longer than 8 days (OR=4.052, 95{\%} CI=1.151-14.263, p=0.0293). Conclusively, the most important predictor of CAA in KD is total duration of fever longer than 8 days. Early identification of IVGG non-responders and active therapeutic intervention for fever in KD cases might decrease the incidence of CAA.",
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