Predictive value of albuminuria in American Indian youth with or without type 2 diabetes

Nan Hee Kim, Meda E. Pavkov, William C. Knowler, Robert L. Hanson, E. Jennifer Weil, Jeffrey M. Curtis, Peter H. Bennett, Robert G. Nelson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

OBJECTIVE: To examine the prognostic significance of elevated albu-minuria in youth with type 2 diabetes. PATIENTS AND METHODS: Cross-sectional and prospective studies were conducted on Pima Indian youth aged 5 to 19 years at baseline who were examined between July 1, 1982, and December 31, 2007. Prevalence and sequential changes in the level of microalbuminuria (30 < albumin-to-creatinine ratio [ACR] < 300 mg/g) and macroalbu-minuria (ACR > 300 mg/g) and incidence of macroalbuminuria were computed according to the presence or absence of type 2 diabetes. RESULTS: The prevalence of microalbuminuria and macroalbuminuria was 6.5% and 0.6% in the 3856 nondiabetic youth and 18.5% and 2.9% in the 103 youth with diabetes, respectively. One hundred forty-one of 187 (75.4%) nondiabetic youth, but only 1 of 14(7.1%)diabetic youth with an elevated ACR (>30 mg/g) regressed to an undetectable or normal ACR (<30 mg/g) on subsequent examination. In a subset of 2666 youth with a median follow-up of 8.1 years, 36 nondiabetic and 30 diabetic youth with baseline ACRs of <300 mg/g developed macroalbuminuria. For a given ACR, the incidence of macroalbuminuria was 15.9-fold (95% con-fidence interval: 11.1-22.6) higher in the diabetic than in the nondia-betic youth. CONCLUSIONS: Elevated albuminuria is infrequent and largely tran-sient in nondiabetic youth, but it is relatively frequent and largely per-sistent in those with diabetes. Microalbuminuria in youth with type 2 diabetes strongly predicts progression to macroalbuminuria, which supports annual screening for albuminuria.

Original languageEnglish
JournalPediatrics
Volume125
Issue number4
DOIs
Publication statusPublished - 2010 Apr 1

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Albuminuria
North American Indians
Type 2 Diabetes Mellitus
Potassium Iodide
Incidence
Cross-Sectional Studies
Prospective Studies

Keywords

  • Diabetic nephropathy
  • Epidemiology
  • Iincidence
  • Longitudinal
  • Prevalence
  • Risk factors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Kim, N. H., Pavkov, M. E., Knowler, W. C., Hanson, R. L., Jennifer Weil, E., Curtis, J. M., ... Nelson, R. G. (2010). Predictive value of albuminuria in American Indian youth with or without type 2 diabetes. Pediatrics, 125(4). https://doi.org/10.1542/peds.2009-1230

Predictive value of albuminuria in American Indian youth with or without type 2 diabetes. / Kim, Nan Hee; Pavkov, Meda E.; Knowler, William C.; Hanson, Robert L.; Jennifer Weil, E.; Curtis, Jeffrey M.; Bennett, Peter H.; Nelson, Robert G.

In: Pediatrics, Vol. 125, No. 4, 01.04.2010.

Research output: Contribution to journalArticle

Kim, NH, Pavkov, ME, Knowler, WC, Hanson, RL, Jennifer Weil, E, Curtis, JM, Bennett, PH & Nelson, RG 2010, 'Predictive value of albuminuria in American Indian youth with or without type 2 diabetes', Pediatrics, vol. 125, no. 4. https://doi.org/10.1542/peds.2009-1230
Kim, Nan Hee ; Pavkov, Meda E. ; Knowler, William C. ; Hanson, Robert L. ; Jennifer Weil, E. ; Curtis, Jeffrey M. ; Bennett, Peter H. ; Nelson, Robert G. / Predictive value of albuminuria in American Indian youth with or without type 2 diabetes. In: Pediatrics. 2010 ; Vol. 125, No. 4.
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abstract = "OBJECTIVE: To examine the prognostic significance of elevated albu-minuria in youth with type 2 diabetes. PATIENTS AND METHODS: Cross-sectional and prospective studies were conducted on Pima Indian youth aged 5 to 19 years at baseline who were examined between July 1, 1982, and December 31, 2007. Prevalence and sequential changes in the level of microalbuminuria (30 < albumin-to-creatinine ratio [ACR] < 300 mg/g) and macroalbu-minuria (ACR > 300 mg/g) and incidence of macroalbuminuria were computed according to the presence or absence of type 2 diabetes. RESULTS: The prevalence of microalbuminuria and macroalbuminuria was 6.5{\%} and 0.6{\%} in the 3856 nondiabetic youth and 18.5{\%} and 2.9{\%} in the 103 youth with diabetes, respectively. One hundred forty-one of 187 (75.4{\%}) nondiabetic youth, but only 1 of 14(7.1{\%})diabetic youth with an elevated ACR (>30 mg/g) regressed to an undetectable or normal ACR (<30 mg/g) on subsequent examination. In a subset of 2666 youth with a median follow-up of 8.1 years, 36 nondiabetic and 30 diabetic youth with baseline ACRs of <300 mg/g developed macroalbuminuria. For a given ACR, the incidence of macroalbuminuria was 15.9-fold (95{\%} con-fidence interval: 11.1-22.6) higher in the diabetic than in the nondia-betic youth. CONCLUSIONS: Elevated albuminuria is infrequent and largely tran-sient in nondiabetic youth, but it is relatively frequent and largely per-sistent in those with diabetes. Microalbuminuria in youth with type 2 diabetes strongly predicts progression to macroalbuminuria, which supports annual screening for albuminuria.",
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T1 - Predictive value of albuminuria in American Indian youth with or without type 2 diabetes

AU - Kim, Nan Hee

AU - Pavkov, Meda E.

AU - Knowler, William C.

AU - Hanson, Robert L.

AU - Jennifer Weil, E.

AU - Curtis, Jeffrey M.

AU - Bennett, Peter H.

AU - Nelson, Robert G.

PY - 2010/4/1

Y1 - 2010/4/1

N2 - OBJECTIVE: To examine the prognostic significance of elevated albu-minuria in youth with type 2 diabetes. PATIENTS AND METHODS: Cross-sectional and prospective studies were conducted on Pima Indian youth aged 5 to 19 years at baseline who were examined between July 1, 1982, and December 31, 2007. Prevalence and sequential changes in the level of microalbuminuria (30 < albumin-to-creatinine ratio [ACR] < 300 mg/g) and macroalbu-minuria (ACR > 300 mg/g) and incidence of macroalbuminuria were computed according to the presence or absence of type 2 diabetes. RESULTS: The prevalence of microalbuminuria and macroalbuminuria was 6.5% and 0.6% in the 3856 nondiabetic youth and 18.5% and 2.9% in the 103 youth with diabetes, respectively. One hundred forty-one of 187 (75.4%) nondiabetic youth, but only 1 of 14(7.1%)diabetic youth with an elevated ACR (>30 mg/g) regressed to an undetectable or normal ACR (<30 mg/g) on subsequent examination. In a subset of 2666 youth with a median follow-up of 8.1 years, 36 nondiabetic and 30 diabetic youth with baseline ACRs of <300 mg/g developed macroalbuminuria. For a given ACR, the incidence of macroalbuminuria was 15.9-fold (95% con-fidence interval: 11.1-22.6) higher in the diabetic than in the nondia-betic youth. CONCLUSIONS: Elevated albuminuria is infrequent and largely tran-sient in nondiabetic youth, but it is relatively frequent and largely per-sistent in those with diabetes. Microalbuminuria in youth with type 2 diabetes strongly predicts progression to macroalbuminuria, which supports annual screening for albuminuria.

AB - OBJECTIVE: To examine the prognostic significance of elevated albu-minuria in youth with type 2 diabetes. PATIENTS AND METHODS: Cross-sectional and prospective studies were conducted on Pima Indian youth aged 5 to 19 years at baseline who were examined between July 1, 1982, and December 31, 2007. Prevalence and sequential changes in the level of microalbuminuria (30 < albumin-to-creatinine ratio [ACR] < 300 mg/g) and macroalbu-minuria (ACR > 300 mg/g) and incidence of macroalbuminuria were computed according to the presence or absence of type 2 diabetes. RESULTS: The prevalence of microalbuminuria and macroalbuminuria was 6.5% and 0.6% in the 3856 nondiabetic youth and 18.5% and 2.9% in the 103 youth with diabetes, respectively. One hundred forty-one of 187 (75.4%) nondiabetic youth, but only 1 of 14(7.1%)diabetic youth with an elevated ACR (>30 mg/g) regressed to an undetectable or normal ACR (<30 mg/g) on subsequent examination. In a subset of 2666 youth with a median follow-up of 8.1 years, 36 nondiabetic and 30 diabetic youth with baseline ACRs of <300 mg/g developed macroalbuminuria. For a given ACR, the incidence of macroalbuminuria was 15.9-fold (95% con-fidence interval: 11.1-22.6) higher in the diabetic than in the nondia-betic youth. CONCLUSIONS: Elevated albuminuria is infrequent and largely tran-sient in nondiabetic youth, but it is relatively frequent and largely per-sistent in those with diabetes. Microalbuminuria in youth with type 2 diabetes strongly predicts progression to macroalbuminuria, which supports annual screening for albuminuria.

KW - Diabetic nephropathy

KW - Epidemiology

KW - Iincidence

KW - Longitudinal

KW - Prevalence

KW - Risk factors

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