Abstract
Echocardiographic parameters can predict cardiovascular events in several clinical settings.However, which echocardiographic parameter is most predictive of each cardiovascular ornon-cardiovascular event in patients starting hemodialysis remains unresolved.Echocardiography was used in 189 patients at the time of starting hemodialysis. Weestablished primary outcomes as follows: cardiovascular events (ischemic heart disease,cerebrovascular disease, peripheral artery disease, and acute heart failure), fatal noncardiovascularevents, all-cause mortality, and all combined events. The most predictableechocardiographic parameter was determined in the Cox hazard ratio model with abackward selection after the adjustment of multiple covariates. Among severalechocardiographic parameters, the E/e' ratio and the left ventricular end-diastolic volume(LVEDV) were the strongest predictors of cardiovascular and non-cardiovascular events,respectively. After the adjustment of clinical and biochemical covariates, the predictabilityof E/e' remained consistent, but LVEDV did not. When clinical events were furtheranalyzed, the significant echocardiographic parameters were as follows: s' for ischemicheart disease and peripheral artery disease, LVEDV and E/e' for acute heart failure, and E/e'for all-cause mortality and all combined events. However, no echocardiographic parameterindependently predicted cerebrovascular disease or non-cardiovascular events. Inconclusion, E/e', s', and LVEDV have independent predictive values for severalcardiovascular and mortality events.
| Original language | English |
|---|---|
| Pages (from-to) | 44-53 |
| Number of pages | 10 |
| Journal | Journal of Korean Medical Science |
| Volume | 30 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
| Externally published | Yes |
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Keywords
- Echocardiography
- Heart failure, diastolic
- Kidney failure, chronic
- Morbidity
- Mortality
- Renal dialysis
ASJC Scopus subject areas
- Medicine(all)
Cite this
Predictive value of echocardiographic parameters for clinical events in patients starting hemodialysis. / Han, Seung Seok; Cho, Goo Yeong; Park, Youn Su; Baek, Seon Ha; Ahn, Shin Young; Kim, Sejoong; Chin, Ho Jun; Chae, Dong Wan; Na, Ki Young.
In: Journal of Korean Medical Science, Vol. 30, No. 1, 01.01.2015, p. 44-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predictive value of echocardiographic parameters for clinical events in patients starting hemodialysis
AU - Han, Seung Seok
AU - Cho, Goo Yeong
AU - Park, Youn Su
AU - Baek, Seon Ha
AU - Ahn, Shin Young
AU - Kim, Sejoong
AU - Chin, Ho Jun
AU - Chae, Dong Wan
AU - Na, Ki Young
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Echocardiographic parameters can predict cardiovascular events in several clinical settings.However, which echocardiographic parameter is most predictive of each cardiovascular ornon-cardiovascular event in patients starting hemodialysis remains unresolved.Echocardiography was used in 189 patients at the time of starting hemodialysis. Weestablished primary outcomes as follows: cardiovascular events (ischemic heart disease,cerebrovascular disease, peripheral artery disease, and acute heart failure), fatal noncardiovascularevents, all-cause mortality, and all combined events. The most predictableechocardiographic parameter was determined in the Cox hazard ratio model with abackward selection after the adjustment of multiple covariates. Among severalechocardiographic parameters, the E/e' ratio and the left ventricular end-diastolic volume(LVEDV) were the strongest predictors of cardiovascular and non-cardiovascular events,respectively. After the adjustment of clinical and biochemical covariates, the predictabilityof E/e' remained consistent, but LVEDV did not. When clinical events were furtheranalyzed, the significant echocardiographic parameters were as follows: s' for ischemicheart disease and peripheral artery disease, LVEDV and E/e' for acute heart failure, and E/e'for all-cause mortality and all combined events. However, no echocardiographic parameterindependently predicted cerebrovascular disease or non-cardiovascular events. Inconclusion, E/e', s', and LVEDV have independent predictive values for severalcardiovascular and mortality events.
AB - Echocardiographic parameters can predict cardiovascular events in several clinical settings.However, which echocardiographic parameter is most predictive of each cardiovascular ornon-cardiovascular event in patients starting hemodialysis remains unresolved.Echocardiography was used in 189 patients at the time of starting hemodialysis. Weestablished primary outcomes as follows: cardiovascular events (ischemic heart disease,cerebrovascular disease, peripheral artery disease, and acute heart failure), fatal noncardiovascularevents, all-cause mortality, and all combined events. The most predictableechocardiographic parameter was determined in the Cox hazard ratio model with abackward selection after the adjustment of multiple covariates. Among severalechocardiographic parameters, the E/e' ratio and the left ventricular end-diastolic volume(LVEDV) were the strongest predictors of cardiovascular and non-cardiovascular events,respectively. After the adjustment of clinical and biochemical covariates, the predictabilityof E/e' remained consistent, but LVEDV did not. When clinical events were furtheranalyzed, the significant echocardiographic parameters were as follows: s' for ischemicheart disease and peripheral artery disease, LVEDV and E/e' for acute heart failure, and E/e'for all-cause mortality and all combined events. However, no echocardiographic parameterindependently predicted cerebrovascular disease or non-cardiovascular events. Inconclusion, E/e', s', and LVEDV have independent predictive values for severalcardiovascular and mortality events.
KW - Echocardiography
KW - Heart failure, diastolic
KW - Kidney failure, chronic
KW - Morbidity
KW - Mortality
KW - Renal dialysis
UR - http://www.scopus.com/inward/record.url?scp=84947129405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947129405&partnerID=8YFLogxK
U2 - 10.3346/jkms.2015.30.1.44
DO - 10.3346/jkms.2015.30.1.44
M3 - Article
VL - 30
SP - 44
EP - 53
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - 1
ER -