TY - JOUR
T1 - Predictive Value of Radiologic Central Compartment Atopic Disease for Identifying Allergy and Asthma in Pediatric Patients
AU - Lee, Kijeong
AU - Kim, Tae Hoon
AU - Lee, Sang Hag
AU - Kang, Chang Ho
AU - Je, Bo-Kyung
AU - Oh, Saelin
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by a grant of Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. O2000711, O2000721).
Publisher Copyright:
© The Author(s) 2021.
PY - 2022/11
Y1 - 2022/11
N2 - Introduction: Central compartment atopic disease (CCAD) has recently been suggested as a phenotype of chronic rhinosinusitis (CRS). This study aims to investigate the prevalence of the radiologic CCAD phenotype in CRS within a pediatric population and identify its ability to predict comorbid allergy and asthma. Methods: Computed tomography and endoscopic examination were conducted on pediatric patients with CRS either with or without nasal polyps. Allergen sensitization was determined with the multiple-allergen simultaneous test and skin prick test. Serum total immunoglobulin E (IgE), peripheral blood eosinophil percentage, and presence of asthma were also evaluated. Results: A total of 82 pediatric patients were enrolled. Overall, 55 (67.1%) of the participants demonstrated aeroallergen sensitization, and 31 (18.9%) of the 164 sides of sinuses were radiologically defined to fit the CCAD phenotype. Patients having CRS with the CCAD phenotype had a higher prevalence of aeroallergen sensitization (87.1% vs 62.4%, P =.008), particularly house dust mite (74.2% vs 53.4%, P =.035), and a higher incidence of asthma (16.1% vs 3.8%, P =.010). Additionally, patients having CRS with the CCAD phenotype demonstrated a high serum total IgE levels (51.6% vs 30.1%, P =.023) in comparison to patients having CRS without CCAD. Conclusion: In pediatric CRS, the radiological CCAD phenotype was associated with allergen sensitization and asthma. Furthermore, the CCAD phenotype was associated with high serum total IgE levels, suggesting allergy etiology should be considered with this type of pediatric patients with CRS.
AB - Introduction: Central compartment atopic disease (CCAD) has recently been suggested as a phenotype of chronic rhinosinusitis (CRS). This study aims to investigate the prevalence of the radiologic CCAD phenotype in CRS within a pediatric population and identify its ability to predict comorbid allergy and asthma. Methods: Computed tomography and endoscopic examination were conducted on pediatric patients with CRS either with or without nasal polyps. Allergen sensitization was determined with the multiple-allergen simultaneous test and skin prick test. Serum total immunoglobulin E (IgE), peripheral blood eosinophil percentage, and presence of asthma were also evaluated. Results: A total of 82 pediatric patients were enrolled. Overall, 55 (67.1%) of the participants demonstrated aeroallergen sensitization, and 31 (18.9%) of the 164 sides of sinuses were radiologically defined to fit the CCAD phenotype. Patients having CRS with the CCAD phenotype had a higher prevalence of aeroallergen sensitization (87.1% vs 62.4%, P =.008), particularly house dust mite (74.2% vs 53.4%, P =.035), and a higher incidence of asthma (16.1% vs 3.8%, P =.010). Additionally, patients having CRS with the CCAD phenotype demonstrated a high serum total IgE levels (51.6% vs 30.1%, P =.023) in comparison to patients having CRS without CCAD. Conclusion: In pediatric CRS, the radiological CCAD phenotype was associated with allergen sensitization and asthma. Furthermore, the CCAD phenotype was associated with high serum total IgE levels, suggesting allergy etiology should be considered with this type of pediatric patients with CRS.
KW - allergy
KW - central compartment atopic disease
KW - chronic rhinosinusitis
KW - computed tomography
KW - pediatrics
UR - http://www.scopus.com/inward/record.url?scp=85102514990&partnerID=8YFLogxK
U2 - 10.1177/0145561321997546
DO - 10.1177/0145561321997546
M3 - Article
C2 - 33689496
AN - SCOPUS:85102514990
VL - 101
SP - 593
EP - 599
JO - Ear, Nose and Throat Journal
JF - Ear, Nose and Throat Journal
SN - 0145-5613
IS - 9
ER -