Predictors of 12-week remission in a nationwide cohort of people with depressive disorders: The CRESCEND study

Jae Min Kim, Sung Wan Kim, Robert Stewart, Seon Young Kim, Jin Sang Yoon, Sung Won Jung, Min-Soo Lee, Hyeon Woo Yim, Tae Youn Jun

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objective: To estimate the 12-week remission rate of patients with depressive disorders and predictors of this in a naturalistic clinical setting in South Korea. Methods: For people with DSM-IV depressive disorders about to receive treatment at 18 hospitals, data on sociodemographic and health status were obtained. A free choice of clinical interventions was allowed and naturalistic follow-up took place at 1, 2, 4, 8, and 12 weeks later. Remission was defined as a Hamilton Depression Rating Scale score of ≤7 sustained to 12 weeks or last follow-up, if earlier. Results: For 723 participants, the 12-week remission rate was 31.4%. Remission was more likely in women, and in patients without a prior history of suicide attempt, and those with lower baseline anxiety. Conclusions: Remission associated with unrestricted clinical interventions was comparable to STAR*D estimates for citalopram alone. Comorbid anxiety and previous suicide attempt were markers of worse outcome.

Original languageEnglish
Pages (from-to)41-50
Number of pages10
JournalHuman Psychopharmacology
Volume26
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

Keywords

  • Anxiety
  • Depression
  • Korea
  • Parasuicide
  • Remission

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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    Kim, J. M., Kim, S. W., Stewart, R., Kim, S. Y., Yoon, J. S., Jung, S. W., Lee, M-S., Yim, H. W., & Jun, T. Y. (2011). Predictors of 12-week remission in a nationwide cohort of people with depressive disorders: The CRESCEND study. Human Psychopharmacology, 26(1), 41-50. https://doi.org/10.1002/hup.1168