Predictors of bone mineral density and osteoporosis in patients attending a rheumatology outpatient clinic

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The aim of this study was to evaluate determinants of bone mineral density (BMD) and osteoporosis in patients attending our rheumatology outpatient clinic. A cross-sectional analysis of 320 patients with rheumatism (248 noninflammatory and 72 inflammatory arthropathies) was done. Bone mineral density was measured in the lumbar spine (posteroanterior and lateral views) using dual-energy X-ray absorptiometry. Single and multiple analyses were used to assess associations between BMD and potential risk factors including age, height, weight, body mass index (BMI), alkaline phosphatase (ALP), calcium (Ca), phosphorous (P), magnesium (Mg), spot urine calcium/creatinine (Ca/Cr) ratio, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), total cumulative dose and mean daily dosage of prednisolone, and duration of therapy. In these patients, there were significant correlations between BMD and age (r=-0.372, P=0.000), height (r=0.308, P=0.000), weight (r=0.145, P=0.011), and ALP (r=-0.262, P=0.000). By multiple regression analysis, age and ALP were found to be significant predictors of BMD (r2=0.253, P < 0.01). Two hundred eighty-three of the patients had osteoporosis. Multiple logistic regression analysis showed that age and ALP were significant determinants for osteoporosis. These observations suggest that age and ALP were the major determinants of BMD and osteoporosis in these patients, suggesting a contribution of increased bone metabolism to loss of bone in cases of rheumatism.

Original languageEnglish
Pages (from-to)67-69
Number of pages3
JournalRheumatology International
Volume23
Issue number2
Publication statusPublished - 2003 Mar 1

Fingerprint

Rheumatology
Ambulatory Care Facilities
Bone Density
Osteoporosis
Alkaline Phosphatase
Rheumatic Diseases
Regression Analysis
Calcium
Weights and Measures
Bone and Bones
Joint Diseases
Blood Sedimentation
Photon Absorptiometry
Prednisolone
C-Reactive Protein
Magnesium
Creatinine
Spine
Body Mass Index
Cross-Sectional Studies

Keywords

  • Low bone mineral density
  • Osteoporosis
  • Rheumatism
  • Risk factors

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

Cite this

@article{dc066273b8264bc6a2580f07b5df2c80,
title = "Predictors of bone mineral density and osteoporosis in patients attending a rheumatology outpatient clinic",
abstract = "The aim of this study was to evaluate determinants of bone mineral density (BMD) and osteoporosis in patients attending our rheumatology outpatient clinic. A cross-sectional analysis of 320 patients with rheumatism (248 noninflammatory and 72 inflammatory arthropathies) was done. Bone mineral density was measured in the lumbar spine (posteroanterior and lateral views) using dual-energy X-ray absorptiometry. Single and multiple analyses were used to assess associations between BMD and potential risk factors including age, height, weight, body mass index (BMI), alkaline phosphatase (ALP), calcium (Ca), phosphorous (P), magnesium (Mg), spot urine calcium/creatinine (Ca/Cr) ratio, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), total cumulative dose and mean daily dosage of prednisolone, and duration of therapy. In these patients, there were significant correlations between BMD and age (r=-0.372, P=0.000), height (r=0.308, P=0.000), weight (r=0.145, P=0.011), and ALP (r=-0.262, P=0.000). By multiple regression analysis, age and ALP were found to be significant predictors of BMD (r2=0.253, P < 0.01). Two hundred eighty-three of the patients had osteoporosis. Multiple logistic regression analysis showed that age and ALP were significant determinants for osteoporosis. These observations suggest that age and ALP were the major determinants of BMD and osteoporosis in these patients, suggesting a contribution of increased bone metabolism to loss of bone in cases of rheumatism.",
keywords = "Low bone mineral density, Osteoporosis, Rheumatism, Risk factors",
author = "Lee, {Young Ho} and Rho, {Young Hee} and Sungjae Choi and Ji, {Jong Dae} and Song, {Gwan Gyu}",
year = "2003",
month = "3",
day = "1",
language = "English",
volume = "23",
pages = "67--69",
journal = "Rheumatology International",
issn = "0172-8172",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Predictors of bone mineral density and osteoporosis in patients attending a rheumatology outpatient clinic

AU - Lee, Young Ho

AU - Rho, Young Hee

AU - Choi, Sungjae

AU - Ji, Jong Dae

AU - Song, Gwan Gyu

PY - 2003/3/1

Y1 - 2003/3/1

N2 - The aim of this study was to evaluate determinants of bone mineral density (BMD) and osteoporosis in patients attending our rheumatology outpatient clinic. A cross-sectional analysis of 320 patients with rheumatism (248 noninflammatory and 72 inflammatory arthropathies) was done. Bone mineral density was measured in the lumbar spine (posteroanterior and lateral views) using dual-energy X-ray absorptiometry. Single and multiple analyses were used to assess associations between BMD and potential risk factors including age, height, weight, body mass index (BMI), alkaline phosphatase (ALP), calcium (Ca), phosphorous (P), magnesium (Mg), spot urine calcium/creatinine (Ca/Cr) ratio, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), total cumulative dose and mean daily dosage of prednisolone, and duration of therapy. In these patients, there were significant correlations between BMD and age (r=-0.372, P=0.000), height (r=0.308, P=0.000), weight (r=0.145, P=0.011), and ALP (r=-0.262, P=0.000). By multiple regression analysis, age and ALP were found to be significant predictors of BMD (r2=0.253, P < 0.01). Two hundred eighty-three of the patients had osteoporosis. Multiple logistic regression analysis showed that age and ALP were significant determinants for osteoporosis. These observations suggest that age and ALP were the major determinants of BMD and osteoporosis in these patients, suggesting a contribution of increased bone metabolism to loss of bone in cases of rheumatism.

AB - The aim of this study was to evaluate determinants of bone mineral density (BMD) and osteoporosis in patients attending our rheumatology outpatient clinic. A cross-sectional analysis of 320 patients with rheumatism (248 noninflammatory and 72 inflammatory arthropathies) was done. Bone mineral density was measured in the lumbar spine (posteroanterior and lateral views) using dual-energy X-ray absorptiometry. Single and multiple analyses were used to assess associations between BMD and potential risk factors including age, height, weight, body mass index (BMI), alkaline phosphatase (ALP), calcium (Ca), phosphorous (P), magnesium (Mg), spot urine calcium/creatinine (Ca/Cr) ratio, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), total cumulative dose and mean daily dosage of prednisolone, and duration of therapy. In these patients, there were significant correlations between BMD and age (r=-0.372, P=0.000), height (r=0.308, P=0.000), weight (r=0.145, P=0.011), and ALP (r=-0.262, P=0.000). By multiple regression analysis, age and ALP were found to be significant predictors of BMD (r2=0.253, P < 0.01). Two hundred eighty-three of the patients had osteoporosis. Multiple logistic regression analysis showed that age and ALP were significant determinants for osteoporosis. These observations suggest that age and ALP were the major determinants of BMD and osteoporosis in these patients, suggesting a contribution of increased bone metabolism to loss of bone in cases of rheumatism.

KW - Low bone mineral density

KW - Osteoporosis

KW - Rheumatism

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=0037356697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037356697&partnerID=8YFLogxK

M3 - Article

C2 - 12634938

AN - SCOPUS:0037356697

VL - 23

SP - 67

EP - 69

JO - Rheumatology International

JF - Rheumatology International

SN - 0172-8172

IS - 2

ER -