TY - JOUR
T1 - Predictors of postherpetic neuralgia in patients with herpes zoster
T2 - A pooled analysis of prospective cohort studies from North and Latin America and Asia
AU - Kawai, Kosuke
AU - Rampakakis, Emmanouil
AU - Tsai, Tsen Fang
AU - Cheong, Hee Jin
AU - Dhitavat, Jittima
AU - Covarrubias, Alejandro Ortiz
AU - Yang, Lin
AU - Cashat-Cruz, Miguel
AU - Monsanto, Homero
AU - Johnson, Kelly
AU - Sampalis, John S.
AU - Acosta, Camilo J.
N1 - Funding Information:
Conflict of interest: KK was a consultant for Merck & Co., Inc. ER, LY, and JSS are employees of JSS Medical Research, the contract Research Organization responsible for the management of the MASTER studies and data analysis. TFT has performed clinical trials and has received speaking fees from MSD. HJC and JD have no conflicts of interest. AOC has received payments to speak from Merck Sharp & Dohme, Abbott Laboratories, Bayer Health Care, and Sanofi Laboratories. HM is an employee of Merck (Latin America Health Outcomes Research Ugad). KJ is a post-doctoral research fellow at Temple University funded by Merck & Co., Inc. MCC is an employee of Merck and Co., Inc. CJA is an employee of Merck Global Health Outcomes – Vaccines.
Publisher Copyright:
© 2015.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Objectives: The most common complication of herpes zoster (HZ) is postherpetic neuralgia (PHN), a persistent pain that can substantially affect quality of life (QoL). This analysis aimed to evaluate predictors of PHN in HZ patients. Methods: A pooled analysis of prospective cohort studies of HZ patients aged ≥50 years from North America (Canada), Latin America (Brazil, Mexico, and Argentina), and Asia (Taiwan, South Korea, and Thailand) was performed. Patients within 14 days of rash onset were included. The incidence of PHN was defined as a worst pain score of ≥3, persisting/appearing at >90 days after rash onset. Socio-demographics, HZ disease characteristics, treatment, pain-related interference with activities of daily living, and health-related QoL were assessed. Results: Of 702 patients with HZ, 148 (21.1%) developed PHN. Similar risks of PHN were observed across geographic regions. On multivariate analysis, older age, greater severity of pain at rash onset, employment status, walking problems at enrollment, and pain interference affecting social relationships were significantly associated with the development of PHN. Conclusions: In addition to older age and severe acute pain, this study suggests that impaired physical and social functioning from acute zoster pain may play a role in the development of PHN in this prospective cohort study of HZ patients from North and Latin America and Asia.
AB - Objectives: The most common complication of herpes zoster (HZ) is postherpetic neuralgia (PHN), a persistent pain that can substantially affect quality of life (QoL). This analysis aimed to evaluate predictors of PHN in HZ patients. Methods: A pooled analysis of prospective cohort studies of HZ patients aged ≥50 years from North America (Canada), Latin America (Brazil, Mexico, and Argentina), and Asia (Taiwan, South Korea, and Thailand) was performed. Patients within 14 days of rash onset were included. The incidence of PHN was defined as a worst pain score of ≥3, persisting/appearing at >90 days after rash onset. Socio-demographics, HZ disease characteristics, treatment, pain-related interference with activities of daily living, and health-related QoL were assessed. Results: Of 702 patients with HZ, 148 (21.1%) developed PHN. Similar risks of PHN were observed across geographic regions. On multivariate analysis, older age, greater severity of pain at rash onset, employment status, walking problems at enrollment, and pain interference affecting social relationships were significantly associated with the development of PHN. Conclusions: In addition to older age and severe acute pain, this study suggests that impaired physical and social functioning from acute zoster pain may play a role in the development of PHN in this prospective cohort study of HZ patients from North and Latin America and Asia.
KW - Asia
KW - Herpes zoster
KW - Latin America
KW - North America
KW - Postherpetic neuralgia
KW - Predictors
UR - http://www.scopus.com/inward/record.url?scp=84928236416&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2015.03.022
DO - 10.1016/j.ijid.2015.03.022
M3 - Article
C2 - 25841633
AN - SCOPUS:84928236416
VL - 34
SP - 126
EP - 131
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
ER -
