Abstract
Objectives: The most common complication of herpes zoster (HZ) is postherpetic neuralgia (PHN), a persistent pain that can substantially affect quality of life (QoL). This analysis aimed to evaluate predictors of PHN in HZ patients. Methods: A pooled analysis of prospective cohort studies of HZ patients aged ≥50 years from North America (Canada), Latin America (Brazil, Mexico, and Argentina), and Asia (Taiwan, South Korea, and Thailand) was performed. Patients within 14 days of rash onset were included. The incidence of PHN was defined as a worst pain score of ≥3, persisting/appearing at >90 days after rash onset. Socio-demographics, HZ disease characteristics, treatment, pain-related interference with activities of daily living, and health-related QoL were assessed. Results: Of 702 patients with HZ, 148 (21.1%) developed PHN. Similar risks of PHN were observed across geographic regions. On multivariate analysis, older age, greater severity of pain at rash onset, employment status, walking problems at enrollment, and pain interference affecting social relationships were significantly associated with the development of PHN. Conclusions: In addition to older age and severe acute pain, this study suggests that impaired physical and social functioning from acute zoster pain may play a role in the development of PHN in this prospective cohort study of HZ patients from North and Latin America and Asia.
| Original language | English |
|---|---|
| Pages (from-to) | 126-131 |
| Number of pages | 6 |
| Journal | International Journal of Infectious Diseases |
| Volume | 34 |
| DOIs | |
| Publication status | Published - 2015 May 1 |
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Keywords
- Asia
- Herpes zoster
- Latin America
- North America
- Postherpetic neuralgia
- Predictors
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
Cite this
Predictors of postherpetic neuralgia in patients with herpes zoster : A pooled analysis of prospective cohort studies from North and Latin America and Asia. / Kawai, Kosuke; Rampakakis, Emmanouil; Tsai, Tsen Fang; Cheong, Hee-Jin; Dhitavat, Jittima; Covarrubias, Alejandro Ortiz; Yang, Lin; Cashat-Cruz, Miguel; Monsanto, Homero; Johnson, Kelly; Sampalis, John S.; Acosta, Camilo J.
In: International Journal of Infectious Diseases, Vol. 34, 01.05.2015, p. 126-131.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Predictors of postherpetic neuralgia in patients with herpes zoster
T2 - A pooled analysis of prospective cohort studies from North and Latin America and Asia
AU - Kawai, Kosuke
AU - Rampakakis, Emmanouil
AU - Tsai, Tsen Fang
AU - Cheong, Hee-Jin
AU - Dhitavat, Jittima
AU - Covarrubias, Alejandro Ortiz
AU - Yang, Lin
AU - Cashat-Cruz, Miguel
AU - Monsanto, Homero
AU - Johnson, Kelly
AU - Sampalis, John S.
AU - Acosta, Camilo J.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Objectives: The most common complication of herpes zoster (HZ) is postherpetic neuralgia (PHN), a persistent pain that can substantially affect quality of life (QoL). This analysis aimed to evaluate predictors of PHN in HZ patients. Methods: A pooled analysis of prospective cohort studies of HZ patients aged ≥50 years from North America (Canada), Latin America (Brazil, Mexico, and Argentina), and Asia (Taiwan, South Korea, and Thailand) was performed. Patients within 14 days of rash onset were included. The incidence of PHN was defined as a worst pain score of ≥3, persisting/appearing at >90 days after rash onset. Socio-demographics, HZ disease characteristics, treatment, pain-related interference with activities of daily living, and health-related QoL were assessed. Results: Of 702 patients with HZ, 148 (21.1%) developed PHN. Similar risks of PHN were observed across geographic regions. On multivariate analysis, older age, greater severity of pain at rash onset, employment status, walking problems at enrollment, and pain interference affecting social relationships were significantly associated with the development of PHN. Conclusions: In addition to older age and severe acute pain, this study suggests that impaired physical and social functioning from acute zoster pain may play a role in the development of PHN in this prospective cohort study of HZ patients from North and Latin America and Asia.
AB - Objectives: The most common complication of herpes zoster (HZ) is postherpetic neuralgia (PHN), a persistent pain that can substantially affect quality of life (QoL). This analysis aimed to evaluate predictors of PHN in HZ patients. Methods: A pooled analysis of prospective cohort studies of HZ patients aged ≥50 years from North America (Canada), Latin America (Brazil, Mexico, and Argentina), and Asia (Taiwan, South Korea, and Thailand) was performed. Patients within 14 days of rash onset were included. The incidence of PHN was defined as a worst pain score of ≥3, persisting/appearing at >90 days after rash onset. Socio-demographics, HZ disease characteristics, treatment, pain-related interference with activities of daily living, and health-related QoL were assessed. Results: Of 702 patients with HZ, 148 (21.1%) developed PHN. Similar risks of PHN were observed across geographic regions. On multivariate analysis, older age, greater severity of pain at rash onset, employment status, walking problems at enrollment, and pain interference affecting social relationships were significantly associated with the development of PHN. Conclusions: In addition to older age and severe acute pain, this study suggests that impaired physical and social functioning from acute zoster pain may play a role in the development of PHN in this prospective cohort study of HZ patients from North and Latin America and Asia.
KW - Asia
KW - Herpes zoster
KW - Latin America
KW - North America
KW - Postherpetic neuralgia
KW - Predictors
UR - http://www.scopus.com/inward/record.url?scp=84928236416&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928236416&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2015.03.022
DO - 10.1016/j.ijid.2015.03.022
M3 - Article
C2 - 25841633
AN - SCOPUS:84928236416
VL - 34
SP - 126
EP - 131
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
SN - 1201-9712
ER -