Predictors of recurrent stroke in patients with symptomatic intracranial arterial stenosis

Jin-Man Jung, Dong Wha Kang, Kyung Ho Yu, Ja Seong Koo, Ju Hun Lee, Jong Moo Park, Keun Sik Hong, Yong Jin Cho, Jong S. Kim, Sun U. Kwon

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE-: Our goal was to investigate whether initial ischemic lesion pattern can predict stroke recurrence in patients with symptomatic intracranial arterial stenosis. METHODS-: Of the Trial of Cilostazol in Symptomatic Intracranial Arterial Stenosis (TOSS)-2 trial participants, we included patients who underwent diffusion-weighted imaging and fluid attenuation inversion recovery imaging at baseline with a follow-up fluid attenuation inversion recovery imaging at 7 months. Based on the diffusion-weighted imaging findings, we classified the initial ischemic lesion patterns according to location (subcortical versus cortical versus subcorticocortical) and multiplicity (single versus multiple). We also evaluated the occurrence of new ischemic lesions on follow-up fluid attenuation inversion recovery as well as clinical stroke in the symptomatic intracranial arterial stenosis territory. RESULTS-: Of 353 patients included in this study, 44 (12.5%) and 13 (3.7%) patients had new ischemic lesions and clinical recurrent stroke in the initial symptomatic intracranial arterial stenosis territory, respectively. On multivariable analysis, the initial lesion patterns of subcorticocortical and multiple lesions were independent predictors of new ischemic lesions in the symptomatic intracranial arterial stenosis territory (OR, 3.01; 95% CI, 1.33-7.01; P=0.03; OR, 2.81; 95% CI, 1.34-5.9; P=0.006). These patterns also predicted clinical recurrent stroke. CONCLUSION-: Subcorticocortical lesions and multiple lesions are radiological predictors of recurrent ischemic stroke in symptomatic patients with intracranial arterial stenosis.

Original languageEnglish
Pages (from-to)2785-2787
Number of pages3
JournalStroke
Volume43
Issue number10
DOIs
Publication statusPublished - 2012 Oct 1

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Pathologic Constriction
Stroke
Recurrence

Keywords

  • intracranial stenosis
  • predictor
  • recurrence

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

Cite this

Jung, J-M., Kang, D. W., Yu, K. H., Koo, J. S., Lee, J. H., Park, J. M., ... Kwon, S. U. (2012). Predictors of recurrent stroke in patients with symptomatic intracranial arterial stenosis. Stroke, 43(10), 2785-2787. https://doi.org/10.1161/STROKEAHA.112.659185

Predictors of recurrent stroke in patients with symptomatic intracranial arterial stenosis. / Jung, Jin-Man; Kang, Dong Wha; Yu, Kyung Ho; Koo, Ja Seong; Lee, Ju Hun; Park, Jong Moo; Hong, Keun Sik; Cho, Yong Jin; Kim, Jong S.; Kwon, Sun U.

In: Stroke, Vol. 43, No. 10, 01.10.2012, p. 2785-2787.

Research output: Contribution to journalArticle

Jung, J-M, Kang, DW, Yu, KH, Koo, JS, Lee, JH, Park, JM, Hong, KS, Cho, YJ, Kim, JS & Kwon, SU 2012, 'Predictors of recurrent stroke in patients with symptomatic intracranial arterial stenosis', Stroke, vol. 43, no. 10, pp. 2785-2787. https://doi.org/10.1161/STROKEAHA.112.659185
Jung, Jin-Man ; Kang, Dong Wha ; Yu, Kyung Ho ; Koo, Ja Seong ; Lee, Ju Hun ; Park, Jong Moo ; Hong, Keun Sik ; Cho, Yong Jin ; Kim, Jong S. ; Kwon, Sun U. / Predictors of recurrent stroke in patients with symptomatic intracranial arterial stenosis. In: Stroke. 2012 ; Vol. 43, No. 10. pp. 2785-2787.
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