Predictors of the patency of self-expandable metallic stents in malignant gastroduodenal obstruction

Seung Han Kim, Hoon-Jai Chun, In Kyung Yoo, Jae Min Lee, Seung Joo Nam, Hyuk Soon Choi, Eun-Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Soon-Ho Um, Chang Duck Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

AIM: To investigate the predictive factors of self-expandable metallic stent patency after stent placement in patients with inoperable malignant gastroduodenal obstruction. METHODS: A total of 116 patients underwent stent placements for inoperable malignant gastroduodenal obstruction at a tertiary academic center. Clinical success was defined as acceptable decompression of the obstructive lesion within the malignant gastroduodenal neoplasm. We evaluated patient comorbidities and clinical statuses using the World Health Organization's scoring system and categorized patient responses to chemotherapy using the Response Evaluation Criteria in Solid Tumors criteria. We analyzed the relationships between possible predictive factors and stent patency. RESULTS: Self-expandable metallic stent placement was technically successful in all patients (100%), and the clinical success rate was 84.2%. In a multivariate Cox proportional hazards model, carcinoembryonic antigen (CEA) levels were correlated with a reduction in stent patency [P = 0.006; adjusted hazard ratio (aHR) = 2.92, 95%CI: 1.36-6.25]. Palliative chemotherapy was statistically associated with an increase in stent patency (P = 0.009; aHR = 0.27, 95%CI: 0.10-0.72). CONCLUSION: CEA levels can easily be measured at the time of stent placement and may help clinicians to predict stent patency and determine the appropriate stent procedure.

Original languageEnglish
Pages (from-to)9134-9141
Number of pages8
JournalWorld Journal of Gastroenterology
Volume21
Issue number30
DOIs
Publication statusPublished - 2015 Aug 14

Fingerprint

Stents
Carcinoembryonic Antigen
Drug Therapy
Self Expandable Metallic Stents
Decompression
Proportional Hazards Models
Comorbidity
Neoplasms

Keywords

  • Carcinoembryonic antigen
  • Malignant gastroduodenal obstruction
  • Patency
  • Predictive factor
  • Stent

ASJC Scopus subject areas

  • Gastroenterology

Cite this

@article{f35ced659a8643a1b2227ff5a8ea601e,
title = "Predictors of the patency of self-expandable metallic stents in malignant gastroduodenal obstruction",
abstract = "AIM: To investigate the predictive factors of self-expandable metallic stent patency after stent placement in patients with inoperable malignant gastroduodenal obstruction. METHODS: A total of 116 patients underwent stent placements for inoperable malignant gastroduodenal obstruction at a tertiary academic center. Clinical success was defined as acceptable decompression of the obstructive lesion within the malignant gastroduodenal neoplasm. We evaluated patient comorbidities and clinical statuses using the World Health Organization's scoring system and categorized patient responses to chemotherapy using the Response Evaluation Criteria in Solid Tumors criteria. We analyzed the relationships between possible predictive factors and stent patency. RESULTS: Self-expandable metallic stent placement was technically successful in all patients (100{\%}), and the clinical success rate was 84.2{\%}. In a multivariate Cox proportional hazards model, carcinoembryonic antigen (CEA) levels were correlated with a reduction in stent patency [P = 0.006; adjusted hazard ratio (aHR) = 2.92, 95{\%}CI: 1.36-6.25]. Palliative chemotherapy was statistically associated with an increase in stent patency (P = 0.009; aHR = 0.27, 95{\%}CI: 0.10-0.72). CONCLUSION: CEA levels can easily be measured at the time of stent placement and may help clinicians to predict stent patency and determine the appropriate stent procedure.",
keywords = "Carcinoembryonic antigen, Malignant gastroduodenal obstruction, Patency, Predictive factor, Stent",
author = "Kim, {Seung Han} and Hoon-Jai Chun and Yoo, {In Kyung} and Lee, {Jae Min} and Nam, {Seung Joo} and Choi, {Hyuk Soon} and Eun-Sun Kim and Bora Keum and Seo, {Yeon Seok} and Jeen, {Yoon Tae} and Lee, {Hong Sik} and Soon-Ho Um and Kim, {Chang Duck}",
year = "2015",
month = "8",
day = "14",
doi = "10.3748/wjg.v21.i30.9134",
language = "English",
volume = "21",
pages = "9134--9141",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "30",

}

TY - JOUR

T1 - Predictors of the patency of self-expandable metallic stents in malignant gastroduodenal obstruction

AU - Kim, Seung Han

AU - Chun, Hoon-Jai

AU - Yoo, In Kyung

AU - Lee, Jae Min

AU - Nam, Seung Joo

AU - Choi, Hyuk Soon

AU - Kim, Eun-Sun

AU - Keum, Bora

AU - Seo, Yeon Seok

AU - Jeen, Yoon Tae

AU - Lee, Hong Sik

AU - Um, Soon-Ho

AU - Kim, Chang Duck

PY - 2015/8/14

Y1 - 2015/8/14

N2 - AIM: To investigate the predictive factors of self-expandable metallic stent patency after stent placement in patients with inoperable malignant gastroduodenal obstruction. METHODS: A total of 116 patients underwent stent placements for inoperable malignant gastroduodenal obstruction at a tertiary academic center. Clinical success was defined as acceptable decompression of the obstructive lesion within the malignant gastroduodenal neoplasm. We evaluated patient comorbidities and clinical statuses using the World Health Organization's scoring system and categorized patient responses to chemotherapy using the Response Evaluation Criteria in Solid Tumors criteria. We analyzed the relationships between possible predictive factors and stent patency. RESULTS: Self-expandable metallic stent placement was technically successful in all patients (100%), and the clinical success rate was 84.2%. In a multivariate Cox proportional hazards model, carcinoembryonic antigen (CEA) levels were correlated with a reduction in stent patency [P = 0.006; adjusted hazard ratio (aHR) = 2.92, 95%CI: 1.36-6.25]. Palliative chemotherapy was statistically associated with an increase in stent patency (P = 0.009; aHR = 0.27, 95%CI: 0.10-0.72). CONCLUSION: CEA levels can easily be measured at the time of stent placement and may help clinicians to predict stent patency and determine the appropriate stent procedure.

AB - AIM: To investigate the predictive factors of self-expandable metallic stent patency after stent placement in patients with inoperable malignant gastroduodenal obstruction. METHODS: A total of 116 patients underwent stent placements for inoperable malignant gastroduodenal obstruction at a tertiary academic center. Clinical success was defined as acceptable decompression of the obstructive lesion within the malignant gastroduodenal neoplasm. We evaluated patient comorbidities and clinical statuses using the World Health Organization's scoring system and categorized patient responses to chemotherapy using the Response Evaluation Criteria in Solid Tumors criteria. We analyzed the relationships between possible predictive factors and stent patency. RESULTS: Self-expandable metallic stent placement was technically successful in all patients (100%), and the clinical success rate was 84.2%. In a multivariate Cox proportional hazards model, carcinoembryonic antigen (CEA) levels were correlated with a reduction in stent patency [P = 0.006; adjusted hazard ratio (aHR) = 2.92, 95%CI: 1.36-6.25]. Palliative chemotherapy was statistically associated with an increase in stent patency (P = 0.009; aHR = 0.27, 95%CI: 0.10-0.72). CONCLUSION: CEA levels can easily be measured at the time of stent placement and may help clinicians to predict stent patency and determine the appropriate stent procedure.

KW - Carcinoembryonic antigen

KW - Malignant gastroduodenal obstruction

KW - Patency

KW - Predictive factor

KW - Stent

UR - http://www.scopus.com/inward/record.url?scp=84940199597&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940199597&partnerID=8YFLogxK

U2 - 10.3748/wjg.v21.i30.9134

DO - 10.3748/wjg.v21.i30.9134

M3 - Article

C2 - 26290640

AN - SCOPUS:84940199597

VL - 21

SP - 9134

EP - 9141

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 30

ER -