TY - JOUR
T1 - Preeclampsia increases the incidence of postpartum cerebrovascular disease in Korean population
AU - Park, Yejin
AU - Cho, Geum Joon
AU - Kim, Log Young
AU - Lee, Tae Seon
AU - Oh, Min Jeong
AU - Kim, Young Han
N1 - Funding Information:
This research was supported by a grant from the Korea Health Technology R & D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, Republic of Korea (HI15C0810).
PY - 2018
Y1 - 2018
N2 - Background: Multiple studies have been reported regarding preeclampsia as a possible risk factor of cerebrovascular disease (CVD). However, the correlation of preeclampsia and CVD, whether it is a cause-effect relationship or they are sharing common predisposing condition, is not well understood. Therefore, the aim of this study was to investigate the association between the preeclampsia during pregnancy and development of postpartum CVD. Methods: A total of 1,384,550 Korean women who had a delivery between January 1, 2010 and December 31, 2012, were enrolled. Women with the risk of CVD within 1 year prior to pregnancy were excluded based on the Charlson comorbidity index. Primary endpoint was the event of CVD within a year from delivery. After exclusion, 1,075,061 women were analyzed. Results: During the follow-up of 1 year postpartum, there were 25,577 preeclampsia out of 1,072,041 women without postpartum CVD (2.39%), and 121 of 3,020 women with postpartum CVD had preeclampsia before delivery (4.01%). In multivariate logistic regression analysis, women who had preeclampsia during pregnancy showed a higher risk for postpartum CVD (odds ratio, 1.64; 95% confidence interval, 1.37-1.98). Conclusion: The incidence of CVD after delivery was higher in women who had preeclampsia during pregnancy.
AB - Background: Multiple studies have been reported regarding preeclampsia as a possible risk factor of cerebrovascular disease (CVD). However, the correlation of preeclampsia and CVD, whether it is a cause-effect relationship or they are sharing common predisposing condition, is not well understood. Therefore, the aim of this study was to investigate the association between the preeclampsia during pregnancy and development of postpartum CVD. Methods: A total of 1,384,550 Korean women who had a delivery between January 1, 2010 and December 31, 2012, were enrolled. Women with the risk of CVD within 1 year prior to pregnancy were excluded based on the Charlson comorbidity index. Primary endpoint was the event of CVD within a year from delivery. After exclusion, 1,075,061 women were analyzed. Results: During the follow-up of 1 year postpartum, there were 25,577 preeclampsia out of 1,072,041 women without postpartum CVD (2.39%), and 121 of 3,020 women with postpartum CVD had preeclampsia before delivery (4.01%). In multivariate logistic regression analysis, women who had preeclampsia during pregnancy showed a higher risk for postpartum CVD (odds ratio, 1.64; 95% confidence interval, 1.37-1.98). Conclusion: The incidence of CVD after delivery was higher in women who had preeclampsia during pregnancy.
KW - Cerebrovascular disease
KW - Insurance claim reporting
KW - Korea
KW - Postpartum period
KW - Preeclampsia
KW - Pregnancy
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U2 - 10.3346/jkms.2018.33.e35
DO - 10.3346/jkms.2018.33.e35
M3 - Article
C2 - 29349936
AN - SCOPUS:85042112808
VL - 33
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - 6
M1 - e35
ER -