Abstract
Background: The purpose of this study was to compare behavioral antinociceptive responses with spinal fos-like immunoreactivity (FLI) for a intravenous ketamine injection between pre vs. postformalin administration in rats. Methods: Sprague-Dawley rats (250-300 g) were prepared to receive either saline or ketamine. All rats were randomly divided into three groups: control, pretreatment and post-treatment group. Formalin (5%) 100 μl was injected into the hindpaw. Pain related behavior and FLI in the lumbar spinal cord was examined. Results: Flinches of phase 2 were 239.3 (22,8), 118.6 (7,5) (P < 0.05 vs. control and post-treatment group), and 186.7 (16,6) in the control, pre and, post-treatment groups, respectively. Fos-like immunoreactivity expression was significantly correlated with phase 2 flinching behavior (P < 0.001). Conclusion: Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia.
| Original language | English |
|---|---|
| Pages (from-to) | 160-165 |
| Number of pages | 6 |
| Journal | Acta Anaesthesiologica Scandinavica |
| Volume | 49 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2005 Feb 1 |
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Keywords
- C-fos
- Formalin test
- Ketamine
- Preemptive
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
Preemptive effect of intravenous ketamine in the rat : Concordance between pain behavior and spinal fos-like immunoreactivity. / Lee, I. H.; Lee, Il Ok.
In: Acta Anaesthesiologica Scandinavica, Vol. 49, No. 2, 01.02.2005, p. 160-165.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preemptive effect of intravenous ketamine in the rat
T2 - Concordance between pain behavior and spinal fos-like immunoreactivity
AU - Lee, I. H.
AU - Lee, Il Ok
PY - 2005/2/1
Y1 - 2005/2/1
N2 - Background: The purpose of this study was to compare behavioral antinociceptive responses with spinal fos-like immunoreactivity (FLI) for a intravenous ketamine injection between pre vs. postformalin administration in rats. Methods: Sprague-Dawley rats (250-300 g) were prepared to receive either saline or ketamine. All rats were randomly divided into three groups: control, pretreatment and post-treatment group. Formalin (5%) 100 μl was injected into the hindpaw. Pain related behavior and FLI in the lumbar spinal cord was examined. Results: Flinches of phase 2 were 239.3 (22,8), 118.6 (7,5) (P < 0.05 vs. control and post-treatment group), and 186.7 (16,6) in the control, pre and, post-treatment groups, respectively. Fos-like immunoreactivity expression was significantly correlated with phase 2 flinching behavior (P < 0.001). Conclusion: Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia.
AB - Background: The purpose of this study was to compare behavioral antinociceptive responses with spinal fos-like immunoreactivity (FLI) for a intravenous ketamine injection between pre vs. postformalin administration in rats. Methods: Sprague-Dawley rats (250-300 g) were prepared to receive either saline or ketamine. All rats were randomly divided into three groups: control, pretreatment and post-treatment group. Formalin (5%) 100 μl was injected into the hindpaw. Pain related behavior and FLI in the lumbar spinal cord was examined. Results: Flinches of phase 2 were 239.3 (22,8), 118.6 (7,5) (P < 0.05 vs. control and post-treatment group), and 186.7 (16,6) in the control, pre and, post-treatment groups, respectively. Fos-like immunoreactivity expression was significantly correlated with phase 2 flinching behavior (P < 0.001). Conclusion: Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia.
KW - C-fos
KW - Formalin test
KW - Ketamine
KW - Preemptive
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U2 - 10.1111/j.1399-6576.2004.00568.x
DO - 10.1111/j.1399-6576.2004.00568.x
M3 - Article
C2 - 15715615
AN - SCOPUS:14644402443
VL - 49
SP - 160
EP - 165
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
SN - 0001-5172
IS - 2
ER -