Prefrontal hemodynamic changes measured using near-infrared spectroscopy during the Valsalva maneuver in patients with orthostatic intolerance

Yoo Hwan Kim, V. Zephaniah Phillips, Seung Ho Paik, Nam Joon Jeon, Beop Min Kim, Byung Jo Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The Valsalva maneuver (VM) with beat-to-beat blood pressure and heart rate monitoring are used to evaluate orthostatic intolerance (OI). However, they lack the ability to detect cerebral hemodynamic changes, which may be a cause of OI symptoms. Therefore, we utilized near-infrared spectroscopy during VM. Patients with OI symptoms and normal healthy subjects were recruited. Patients were subgrouped according to VM results: patients with normal VM (NVM) and abnormal VM (AbVM). Oxyhemoglobin (HbO), deoxyhemoglobin, and total hemoglobin changes were measured at four different source-detector distances (SD) (15, 30, 36, and 45 mm), and latency, amplitude, duration, and integrated total signal were calculated. Those parameters were compared between a normal healthy control (HC) group and the two OI patient subgroups. We found that HbO increment latency at 30-mm SD in the HC, NVM, and AbVM groups was as follows: 0.39±0.23s, 2.79±0.36s, and 8.14±0.55s, respectively (p<0.05). Among the four parameters we evaluated, latency of HbO increment was the best marker for differentiating OI.

Original languageEnglish
Article number015002
JournalNeurophotonics
Volume5
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Keywords

  • Valsalva maneuver
  • near-infrared
  • orthostatic intolerance
  • spectroscopy

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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