Prefrontal hemodynamic changes measured using near-infrared spectroscopy during the Valsalva maneuver in patients with orthostatic intolerance

Yoo Hwan Kim, V. Zephaniah Phillips, Seung Ho Paik, Nam Joon Jeon, Beop-Min Kim, Byung Jo Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Valsalva maneuver (VM) with beat-to-beat blood pressure and heart rate monitoring are used to evaluate orthostatic intolerance (OI). However, they lack the ability to detect cerebral hemodynamic changes, which may be a cause of OI symptoms. Therefore, we utilized near-infrared spectroscopy during VM. Patients with OI symptoms and normal healthy subjects were recruited. Patients were subgrouped according to VM results: patients with normal VM (NVM) and abnormal VM (AbVM). Oxyhemoglobin (HbO), deoxyhemoglobin, and total hemoglobin changes were measured at four different source-detector distances (SD) (15, 30, 36, and 45 mm), and latency, amplitude, duration, and integrated total signal were calculated. Those parameters were compared between a normal healthy control (HC) group and the two OI patient subgroups. We found that HbO increment latency at 30-mm SD in the HC, NVM, and AbVM groups was as follows: 0.39±0.23s, 2.79±0.36s, and 8.14±0.55s, respectively (p<0.05). Among the four parameters we evaluated, latency of HbO increment was the best marker for differentiating OI.

Original languageEnglish
Article number015002
JournalNeurophotonics
Volume5
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

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Orthostatic Intolerance
Valsalva Maneuver
Near-Infrared Spectroscopy
Hemodynamics
Oxyhemoglobins
Healthy Volunteers
Hemoglobins
Heart Rate
Blood Pressure
Control Groups

Keywords

  • near-infrared
  • orthostatic intolerance
  • spectroscopy
  • Valsalva maneuver

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Prefrontal hemodynamic changes measured using near-infrared spectroscopy during the Valsalva maneuver in patients with orthostatic intolerance. / Kim, Yoo Hwan; Phillips, V. Zephaniah; Paik, Seung Ho; Jeon, Nam Joon; Kim, Beop-Min; Kim, Byung Jo.

In: Neurophotonics, Vol. 5, No. 1, 015002, 01.01.2018.

Research output: Contribution to journalArticle

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