Pregabalin augmentation of antidepressants in patients with accident-related posttraumatic stress disorder: An open label pilot study

Chi Un Pae, David M. Marks, Changsu Han, Prakash S. Masand, Ashwin A. Patkar

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

This study evaluated the efficacy of pregabalin augmentation of antidepressant treatment in patients with posttraumatic stress disorder (PTSD). Nine patients meeting Diagnostic and Statistical Manual, fourth edition criteria for PTSD who were on stable doses of antidepressants were treated open label with flexibly dosed pregabalin for 6 weeks. All patients were assessed with the Short PTSD Rating Interview, Montgomery-Asberg Depression Rating Scale, Patient Global Impressionseverity, Visual Analog Scale-pain, and Sheehan Disability Scale at baseline and weeks 2, 4, and 6. Significant reductions were observed in all effectiveness measures from week 4 to the end of the study. In particular, the numerical improvement of the Visual Analog Scale-pain score was most robust (- 53.4%, P=0.007). Pregabalin augmentation was effective and well tolerated during the study. Our findings warrant adequately powered, placebocontrolled clinical trials to confirm the usefulness of pregabalin augmentation of antidepressants in patients with PTSD.

Original languageEnglish
Pages (from-to)29-33
Number of pages5
JournalInternational clinical psychopharmacology
Volume24
Issue number1
DOIs
Publication statusPublished - 2009 Jan

Keywords

  • Antidepressant
  • Augmentation
  • Posttraumatic stress disorder
  • Pregabalin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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