Abstract
Background: The mechanism of restenosis after stent implantation principally is neointimal hyperplasia. There is evidence that monocytes play a important role in in-stent restenosis (ISR) after stent implantation. Hypothesis: This study assessed the relationship between preinterventional peak monocyte count and neointimal growth after successful stent implantation. Methods: We performed coronary stent implantation in 85 patients (85 de novo lesions). Peripheral blood sample was obtained in all patients every 12 h before coronary angiography for measurement of peripheral monocytes. All patients received angiographic and intravascular ultrasound (IVUS) follow-up at 6 months after stenting. Results: The preinterventional circulating monocyte count was significantly higher in the ISR group than that in the group without ISR (654 ± 62/vs. 461 ± 222/mm3, p < 0.001) and was significantly higher in the reintervention group than that in the no-reintervention group (660 ± 72/vs. 470 ± 216/mm3, p < 0.001). The incidence of ISR and repeat intervention associated with preinterventional monocyte count was highest among the patients in the highest tertile, who were at a 2.64-fold increased risk of ISR and 3.22-fold increased risk of repeat intervention compared with the patients in the lowest tertile. A significant positive correlation was found between preinterventional peak monocyte count and preinterventional plaque and media cross-sectional area and follow-up neointima area (r = 0.311, p = 0.007, r = 0.465, p < 0.001, respectively). The neointima area associated with preinterventional monocyte count was largest among the patients in the highest tertile, that is, 2-fold larger than that of the patients in the lowest tertile (p < 0.001) and 1.44-fold larger than that of the patients in the middle tertile (p = 0.001). Conclusion: Our results suggest that circulating preinterventional monocytes play a principal role in the process of in-stent neointimal growth after successful stent implantation.
| Original language | English |
|---|---|
| Pages (from-to) | 512-518 |
| Number of pages | 7 |
| Journal | Clinical Cardiology |
| Volume | 28 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2005 Jan 1 |
| Externally published | Yes |
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Keywords
- Coronary artery disease
- Inflammation
- Restenosis
- Stents
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Preinterventional peak monocyte count and in-stent intimal hyperplasia after coronary stent implantation in human coronary arteries. / Hong, Young Joon; Jeong, Myung Ho; Lim, Sang Yeob; Lee, Sang Rok; Kim, Kye Hun; Sohn, Il Suk; Park, Hyung Wook; Kim, Ju Han; Kim, Weon; Ahn, Youngkeun; Cho, Jeong Gwan; Park, Jong Chun; Kang, Jung Chaee.
In: Clinical Cardiology, Vol. 28, No. 11, 01.01.2005, p. 512-518.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preinterventional peak monocyte count and in-stent intimal hyperplasia after coronary stent implantation in human coronary arteries
AU - Hong, Young Joon
AU - Jeong, Myung Ho
AU - Lim, Sang Yeob
AU - Lee, Sang Rok
AU - Kim, Kye Hun
AU - Sohn, Il Suk
AU - Park, Hyung Wook
AU - Kim, Ju Han
AU - Kim, Weon
AU - Ahn, Youngkeun
AU - Cho, Jeong Gwan
AU - Park, Jong Chun
AU - Kang, Jung Chaee
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Background: The mechanism of restenosis after stent implantation principally is neointimal hyperplasia. There is evidence that monocytes play a important role in in-stent restenosis (ISR) after stent implantation. Hypothesis: This study assessed the relationship between preinterventional peak monocyte count and neointimal growth after successful stent implantation. Methods: We performed coronary stent implantation in 85 patients (85 de novo lesions). Peripheral blood sample was obtained in all patients every 12 h before coronary angiography for measurement of peripheral monocytes. All patients received angiographic and intravascular ultrasound (IVUS) follow-up at 6 months after stenting. Results: The preinterventional circulating monocyte count was significantly higher in the ISR group than that in the group without ISR (654 ± 62/vs. 461 ± 222/mm3, p < 0.001) and was significantly higher in the reintervention group than that in the no-reintervention group (660 ± 72/vs. 470 ± 216/mm3, p < 0.001). The incidence of ISR and repeat intervention associated with preinterventional monocyte count was highest among the patients in the highest tertile, who were at a 2.64-fold increased risk of ISR and 3.22-fold increased risk of repeat intervention compared with the patients in the lowest tertile. A significant positive correlation was found between preinterventional peak monocyte count and preinterventional plaque and media cross-sectional area and follow-up neointima area (r = 0.311, p = 0.007, r = 0.465, p < 0.001, respectively). The neointima area associated with preinterventional monocyte count was largest among the patients in the highest tertile, that is, 2-fold larger than that of the patients in the lowest tertile (p < 0.001) and 1.44-fold larger than that of the patients in the middle tertile (p = 0.001). Conclusion: Our results suggest that circulating preinterventional monocytes play a principal role in the process of in-stent neointimal growth after successful stent implantation.
AB - Background: The mechanism of restenosis after stent implantation principally is neointimal hyperplasia. There is evidence that monocytes play a important role in in-stent restenosis (ISR) after stent implantation. Hypothesis: This study assessed the relationship between preinterventional peak monocyte count and neointimal growth after successful stent implantation. Methods: We performed coronary stent implantation in 85 patients (85 de novo lesions). Peripheral blood sample was obtained in all patients every 12 h before coronary angiography for measurement of peripheral monocytes. All patients received angiographic and intravascular ultrasound (IVUS) follow-up at 6 months after stenting. Results: The preinterventional circulating monocyte count was significantly higher in the ISR group than that in the group without ISR (654 ± 62/vs. 461 ± 222/mm3, p < 0.001) and was significantly higher in the reintervention group than that in the no-reintervention group (660 ± 72/vs. 470 ± 216/mm3, p < 0.001). The incidence of ISR and repeat intervention associated with preinterventional monocyte count was highest among the patients in the highest tertile, who were at a 2.64-fold increased risk of ISR and 3.22-fold increased risk of repeat intervention compared with the patients in the lowest tertile. A significant positive correlation was found between preinterventional peak monocyte count and preinterventional plaque and media cross-sectional area and follow-up neointima area (r = 0.311, p = 0.007, r = 0.465, p < 0.001, respectively). The neointima area associated with preinterventional monocyte count was largest among the patients in the highest tertile, that is, 2-fold larger than that of the patients in the lowest tertile (p < 0.001) and 1.44-fold larger than that of the patients in the middle tertile (p = 0.001). Conclusion: Our results suggest that circulating preinterventional monocytes play a principal role in the process of in-stent neointimal growth after successful stent implantation.
KW - Coronary artery disease
KW - Inflammation
KW - Restenosis
KW - Stents
UR - http://www.scopus.com/inward/record.url?scp=27744433804&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744433804&partnerID=8YFLogxK
U2 - 10.1002/clc.4960281105
DO - 10.1002/clc.4960281105
M3 - Article
C2 - 16450794
AN - SCOPUS:27744433804
VL - 28
SP - 512
EP - 518
JO - Clinical Cardiology
JF - Clinical Cardiology
SN - 0160-9289
IS - 11
ER -