Preliminary result of stereotactic body radiotherapy as a local salvage treatment for inoperable hepatocellular carcinoma

Young Seok Seo, Mi Sook Kim, Sung Yul Yoo, Chul Koo Cho, Chul Won Choi, Jin Ho Kim, Chul Ju Han, Su Cheol Park, Byung Hee Lee, Young Han Kim, Dong Han Lee

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103 Citations (Scopus)

Abstract

Background and Objectives: To evaluate the toxicity and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of localized hepatocellular carcinoma (HCC) in the absence of another standard treatment option. Methods: The authors reviewed the details of 38 patients with inoperable HCC (diameter < 10 cm) treated by SBRT in a prospectively registered database at their institution. All patients had been treated by transcatheter arterial chemoembolization before SBRT, which had been finally deemed ineffective. SBRT dosages (33-57Gy in three or four fractions) were administered according to tumor volumes, which ranged from 11 to 464 ml (median, 40.5 ml). Results: Two-year overall survival and local progression-free survival rates were 61.4% and 66.4%, respectively. The local response rate was 63% at 3 months after SBRT. A high radiation dose was found to be independently related to survival. A decline in liver function was observed in six patients (16%) and Grade 3 musculoskeletal toxicity in one patient (2.7%). Conclusions: This study showed that SBRT can be safely administered to select HCC patients, and these results suggest that this technique should be considered a salvage treatment. A further well-controlled large-scale study and longer follow-up are needed to determine optimal dose-fraction schedules and characterize late complications.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalJournal of Surgical Oncology
Volume102
Issue number3
DOIs
Publication statusPublished - 2010 Sep 1
Externally publishedYes

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Keywords

  • CyberKnife
  • Hepatocellular carcinoma
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Seo, Y. S., Kim, M. S., Yoo, S. Y., Cho, C. K., Choi, C. W., Kim, J. H., Han, C. J., Park, S. C., Lee, B. H., Kim, Y. H., & Lee, D. H. (2010). Preliminary result of stereotactic body radiotherapy as a local salvage treatment for inoperable hepatocellular carcinoma. Journal of Surgical Oncology, 102(3), 209-214. https://doi.org/10.1002/jso.21593