Preliminary result of stereotactic body radiotherapy as a local salvage treatment for inoperable hepatocellular carcinoma

Young Seok Seo, Mi Sook Kim, Sung Yul Yoo, Chul Koo Cho, Chul Won Choi, Jin Ho Kim, Chul Ju Han, Su Cheol Park, Byung Hee Lee, Young Han Kim, Dong Han Lee

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Background and Objectives: To evaluate the toxicity and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of localized hepatocellular carcinoma (HCC) in the absence of another standard treatment option. Methods: The authors reviewed the details of 38 patients with inoperable HCC (diameter < 10 cm) treated by SBRT in a prospectively registered database at their institution. All patients had been treated by transcatheter arterial chemoembolization before SBRT, which had been finally deemed ineffective. SBRT dosages (33-57Gy in three or four fractions) were administered according to tumor volumes, which ranged from 11 to 464 ml (median, 40.5 ml). Results: Two-year overall survival and local progression-free survival rates were 61.4% and 66.4%, respectively. The local response rate was 63% at 3 months after SBRT. A high radiation dose was found to be independently related to survival. A decline in liver function was observed in six patients (16%) and Grade 3 musculoskeletal toxicity in one patient (2.7%). Conclusions: This study showed that SBRT can be safely administered to select HCC patients, and these results suggest that this technique should be considered a salvage treatment. A further well-controlled large-scale study and longer follow-up are needed to determine optimal dose-fraction schedules and characterize late complications.

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalJournal of Surgical Oncology
Volume102
Issue number3
DOIs
Publication statusPublished - 2010 Sep 1
Externally publishedYes

Fingerprint

Salvage Therapy
Radiosurgery
Hepatocellular Carcinoma
Radiotherapy Dosage
Survival
Tumor Burden
Disease-Free Survival
Appointments and Schedules
Survival Rate
Databases
Radiation
Liver
Therapeutics

Keywords

  • CyberKnife
  • Hepatocellular carcinoma
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Preliminary result of stereotactic body radiotherapy as a local salvage treatment for inoperable hepatocellular carcinoma. / Seo, Young Seok; Kim, Mi Sook; Yoo, Sung Yul; Cho, Chul Koo; Choi, Chul Won; Kim, Jin Ho; Han, Chul Ju; Park, Su Cheol; Lee, Byung Hee; Kim, Young Han; Lee, Dong Han.

In: Journal of Surgical Oncology, Vol. 102, No. 3, 01.09.2010, p. 209-214.

Research output: Contribution to journalArticle

Seo, YS, Kim, MS, Yoo, SY, Cho, CK, Choi, CW, Kim, JH, Han, CJ, Park, SC, Lee, BH, Kim, YH & Lee, DH 2010, 'Preliminary result of stereotactic body radiotherapy as a local salvage treatment for inoperable hepatocellular carcinoma', Journal of Surgical Oncology, vol. 102, no. 3, pp. 209-214. https://doi.org/10.1002/jso.21593
Seo, Young Seok ; Kim, Mi Sook ; Yoo, Sung Yul ; Cho, Chul Koo ; Choi, Chul Won ; Kim, Jin Ho ; Han, Chul Ju ; Park, Su Cheol ; Lee, Byung Hee ; Kim, Young Han ; Lee, Dong Han. / Preliminary result of stereotactic body radiotherapy as a local salvage treatment for inoperable hepatocellular carcinoma. In: Journal of Surgical Oncology. 2010 ; Vol. 102, No. 3. pp. 209-214.
@article{26c2e77d4bf34cef8e9ab215cdf6f6e7,
title = "Preliminary result of stereotactic body radiotherapy as a local salvage treatment for inoperable hepatocellular carcinoma",
abstract = "Background and Objectives: To evaluate the toxicity and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of localized hepatocellular carcinoma (HCC) in the absence of another standard treatment option. Methods: The authors reviewed the details of 38 patients with inoperable HCC (diameter < 10 cm) treated by SBRT in a prospectively registered database at their institution. All patients had been treated by transcatheter arterial chemoembolization before SBRT, which had been finally deemed ineffective. SBRT dosages (33-57Gy in three or four fractions) were administered according to tumor volumes, which ranged from 11 to 464 ml (median, 40.5 ml). Results: Two-year overall survival and local progression-free survival rates were 61.4{\%} and 66.4{\%}, respectively. The local response rate was 63{\%} at 3 months after SBRT. A high radiation dose was found to be independently related to survival. A decline in liver function was observed in six patients (16{\%}) and Grade 3 musculoskeletal toxicity in one patient (2.7{\%}). Conclusions: This study showed that SBRT can be safely administered to select HCC patients, and these results suggest that this technique should be considered a salvage treatment. A further well-controlled large-scale study and longer follow-up are needed to determine optimal dose-fraction schedules and characterize late complications.",
keywords = "CyberKnife, Hepatocellular carcinoma, Stereotactic radiotherapy",
author = "Seo, {Young Seok} and Kim, {Mi Sook} and Yoo, {Sung Yul} and Cho, {Chul Koo} and Choi, {Chul Won} and Kim, {Jin Ho} and Han, {Chul Ju} and Park, {Su Cheol} and Lee, {Byung Hee} and Kim, {Young Han} and Lee, {Dong Han}",
year = "2010",
month = "9",
day = "1",
doi = "10.1002/jso.21593",
language = "English",
volume = "102",
pages = "209--214",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Preliminary result of stereotactic body radiotherapy as a local salvage treatment for inoperable hepatocellular carcinoma

AU - Seo, Young Seok

AU - Kim, Mi Sook

AU - Yoo, Sung Yul

AU - Cho, Chul Koo

AU - Choi, Chul Won

AU - Kim, Jin Ho

AU - Han, Chul Ju

AU - Park, Su Cheol

AU - Lee, Byung Hee

AU - Kim, Young Han

AU - Lee, Dong Han

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Background and Objectives: To evaluate the toxicity and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of localized hepatocellular carcinoma (HCC) in the absence of another standard treatment option. Methods: The authors reviewed the details of 38 patients with inoperable HCC (diameter < 10 cm) treated by SBRT in a prospectively registered database at their institution. All patients had been treated by transcatheter arterial chemoembolization before SBRT, which had been finally deemed ineffective. SBRT dosages (33-57Gy in three or four fractions) were administered according to tumor volumes, which ranged from 11 to 464 ml (median, 40.5 ml). Results: Two-year overall survival and local progression-free survival rates were 61.4% and 66.4%, respectively. The local response rate was 63% at 3 months after SBRT. A high radiation dose was found to be independently related to survival. A decline in liver function was observed in six patients (16%) and Grade 3 musculoskeletal toxicity in one patient (2.7%). Conclusions: This study showed that SBRT can be safely administered to select HCC patients, and these results suggest that this technique should be considered a salvage treatment. A further well-controlled large-scale study and longer follow-up are needed to determine optimal dose-fraction schedules and characterize late complications.

AB - Background and Objectives: To evaluate the toxicity and efficacy of stereotactic body radiotherapy (SBRT) for the treatment of localized hepatocellular carcinoma (HCC) in the absence of another standard treatment option. Methods: The authors reviewed the details of 38 patients with inoperable HCC (diameter < 10 cm) treated by SBRT in a prospectively registered database at their institution. All patients had been treated by transcatheter arterial chemoembolization before SBRT, which had been finally deemed ineffective. SBRT dosages (33-57Gy in three or four fractions) were administered according to tumor volumes, which ranged from 11 to 464 ml (median, 40.5 ml). Results: Two-year overall survival and local progression-free survival rates were 61.4% and 66.4%, respectively. The local response rate was 63% at 3 months after SBRT. A high radiation dose was found to be independently related to survival. A decline in liver function was observed in six patients (16%) and Grade 3 musculoskeletal toxicity in one patient (2.7%). Conclusions: This study showed that SBRT can be safely administered to select HCC patients, and these results suggest that this technique should be considered a salvage treatment. A further well-controlled large-scale study and longer follow-up are needed to determine optimal dose-fraction schedules and characterize late complications.

KW - CyberKnife

KW - Hepatocellular carcinoma

KW - Stereotactic radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=77956358143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956358143&partnerID=8YFLogxK

U2 - 10.1002/jso.21593

DO - 10.1002/jso.21593

M3 - Article

C2 - 20740576

AN - SCOPUS:77956358143

VL - 102

SP - 209

EP - 214

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 3

ER -