Prenatal development toxicity study of zinc oxide nanoparticles in rats

Jeong Sup Hong, Myeong Kyu Park, Min Seok Kim, Jeong Hyeon Lim, Gil Jong Park, Eun Ho Maeng, Jae Ho Shin, Meyoung-Kon Kim, Jayoung Jeong, Jin A. Park, Jong Choon Kim, Ho Chul Shin

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

This study investigated the potential adverse effects of zinc oxide nanoparticles ([ZnOSM20(+) NPs] zinc oxide nanoparticles, positively charged, 20 nm) on pregnant dams and embryo–fetal development after maternal exposure over the period of gestational days 5–19 with Sprague-Dawley rats. ZnOSM20(+) NPs were administered to pregnant rats by gavage at 0, 100, 200, and 400 mg/kg/day. All dams were subjected to a cesarean section on gestational day 20, and all of the fetuses were examined for external, visceral, and skeletal alterations. Toxicity in the dams manifested as significantly decreased body weight after administration of 400 mg/kg/day NPs; reduced food consumption after administration of 200 and 400 mg/kg/day NPs; and decreased liver weight and increased adrenal glands weight after administration of 400 mg/kg/day NPs. However, no treatment-related difference in: number of corpora lutea; number of implantation sites; implantation rate (%); resorption; dead fetuses; litter size; fetal deaths and placental weights; and sex ratio were observed between the groups. On the other hand, significant decreases between treatment groups and controls were seen for fetal weights after administration of 400 mg/kg/day NPs. Morphological examinations of the fetuses demonstrated significant differences in incidences of abnormalities in the group administered 400mg/kg/day. Meanwhile, no significant difference was found in the Zn content of fetal tissue between the control and high-dose groups. These results showed that oral doses for the study with 15-days repeated of ZnOSM20(+) NPs were maternotoxic in the 200 mg/kg/day group, and embryotoxic in the 400 mg/kg/day group.

Original languageEnglish
Pages (from-to)159-171
Number of pages13
JournalInternational Journal of Nanomedicine
Volume9
DOIs
Publication statusPublished - 2014 Dec 15

Keywords

  • Developmental toxicity
  • Maternal toxicity
  • Nanotoxicology
  • Teratogenicity

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Hong, J. S., Park, M. K., Kim, M. S., Lim, J. H., Park, G. J., Maeng, E. H., Shin, J. H., Kim, M-K., Jeong, J., Park, J. A., Kim, J. C., & Shin, H. C. (2014). Prenatal development toxicity study of zinc oxide nanoparticles in rats. International Journal of Nanomedicine, 9, 159-171. https://doi.org/10.2147/IJN.S57932