Abstract
Three new prenylated isoflavones, 5,7-dihydroxy-6-(2″-hydroxy- 3″-methylbut-3″-enyl)-4′-methoxylisoflavone (1), 5,4′-dihydroxy-6-(3″-methylbut-2′-enyl)-2‴-(4‴- hydroxy-4‴-methylethyl)-3‴-methoxydihydrofurano-[4‴, 5‴;7,8]isoflavone (2), and 5,4′-dihydroxy-8-(3″-methylbut- 2″-enyl)-2‴-(4‴-hydroxy-4‴-methylethyl) furano-[4‴,5‴;6,7]isoflavone (3), a benzylated dihydroflavonol, 5,7,4′-trihydroxy-8-p-hydroxybenzyldihydroflavonol (4), and eight known flavonoids (5-12) were isolated from the fruits of Cudrania tricuspidata. The structures of these compounds were determined on the basis of MS and 1H and 13C NMR spectroscopic data, including 2D NMR experiments. Compounds 2, 3, 6, 7, 8, 10, 11, and 12 inhibited LPS-induced nitric oxide production, with IC50 values of 11.8-41.8 μM.
Original language | English |
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Pages (from-to) | 164-167 |
Number of pages | 4 |
Journal | Journal of Natural Products |
Volume | 72 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2009 Jan |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry