Prenylated and benzylated flavonoids from the fruits of Cudrania tricuspidata

Hua Han Xiang, Su Hong Seong, Qinghao Jin, Dayu Li, Hyun Kyu Kim, Jeongrai Lee, Hyung Kwon Suk, Dongho Lee, Chong Kil Lee, Koo Lee Myung, Yeon Hwang Bang

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34 Citations (Scopus)

Abstract

Three new prenylated isoflavones, 5,7-dihydroxy-6-(2″-hydroxy- 3″-methylbut-3″-enyl)-4′-methoxylisoflavone (1), 5,4′-dihydroxy-6-(3″-methylbut-2′-enyl)-2‴-(4‴- hydroxy-4‴-methylethyl)-3‴-methoxydihydrofurano-[4‴, 5‴;7,8]isoflavone (2), and 5,4′-dihydroxy-8-(3″-methylbut- 2″-enyl)-2‴-(4‴-hydroxy-4‴-methylethyl) furano-[4‴,5‴;6,7]isoflavone (3), a benzylated dihydroflavonol, 5,7,4′-trihydroxy-8-p-hydroxybenzyldihydroflavonol (4), and eight known flavonoids (5-12) were isolated from the fruits of Cudrania tricuspidata. The structures of these compounds were determined on the basis of MS and 1H and 13C NMR spectroscopic data, including 2D NMR experiments. Compounds 2, 3, 6, 7, 8, 10, 11, and 12 inhibited LPS-induced nitric oxide production, with IC50 values of 11.8-41.8 μM.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
JournalJournal of Natural Products
Volume72
Issue number1
DOIs
Publication statusPublished - 2009 Jan 1

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ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Xiang, H. H., Seong, S. H., Jin, Q., Li, D., Kim, H. K., Lee, J., Suk, H. K., Lee, D., Lee, C. K., Myung, K. L., & Bang, Y. H. (2009). Prenylated and benzylated flavonoids from the fruits of Cudrania tricuspidata. Journal of Natural Products, 72(1), 164-167. https://doi.org/10.1021/np800418j