Prenylated xanthones from the root bark of Cudrania tricuspidata

Hye Hwang Ji, Su Hong Seong, Hua Han Xiang, Sang Hwang Ji, Dongho Lee, Heesoon Lee, Pyo Yun Yeo, Youngsoo Kim, Seup Ro Jai, Yeon Hwang Bang

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36 Citations (Scopus)

Abstract

Four new prenylated xanthones, cudratricusxanthones J-M (1-4), were isolated from the CH2Cl2-soluble extract of the root bark of Cudrania tricuspidata, along with four known prenylated xanthones, isocudraxanthone K (5), cudraxanthone C (6), cudratricusxanthone A (7), and cudraxanthone L (8), and three known prenylated flavonoids, cudraflavone A (9), cudraflavanone A (10), and cudraflavone B (11). The structures of compounds 1-4 were elucidated using spectroscopic methods. Cudratricusxanthone A (7), cudraflavanone A (10), and cudraflavone B (11) showed moderate inhibitory effects on mouse brain monoamine oxidase (MAO) with IC50 values of 88.3, 89.7, and 80.0 μM, respectively.

Original languageEnglish
Pages (from-to)1207-1209
Number of pages3
JournalJournal of Natural Products
Volume70
Issue number7
DOIs
Publication statusPublished - 2007 Jul 1

ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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    Ji, H. H., Seong, S. H., Xiang, H. H., Ji, S. H., Lee, D., Lee, H., Yeo, P. Y., Kim, Y., Jai, S. R., & Bang, Y. H. (2007). Prenylated xanthones from the root bark of Cudrania tricuspidata. Journal of Natural Products, 70(7), 1207-1209. https://doi.org/10.1021/np070059k