Preparation and antibacterial activity of chitosan microshperes in a solid dispersing system

Ming Kong; Xi Guang Chen; Yu Ping Xue; Cheng Sheng Liu; Le Jun Yu; Qiu Xia Ji; Dong Su Cha; Hyun Jin Park

doi:10.1007/s11706-008-0036-2

Preparation and antibacterial activity of chitosan microshperes in a solid dispersing system

Ming Kong, Xi Guang Chen, Yu Ping Xue, Cheng Sheng Liu, Le Jun Yu, Qiu Xia Ji, Dong Su Cha, Hyun Jin Park

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

57 Citations (Scopus)

Abstract

In this study, we investigated the interface contacting inhibition behaviors of chitosan against bacterial in the dispersing state. For that purpose, chitosan microspheres (CMs) in the dispersing state was prepared by the emulsification cross-linking method. The CMs had smooth surface and spherical shape with the diameter of about 124 μm. They were stable after sterilization at 121°C and 150 kPa for 20 min. The CMs had similar antibacterial activity to that of chitosan in the solution form. Their antibacterial activities increased with the increase of the CM concentration, while decreased with the increase of pH of the system. It was found that the CMs with the degree of deacetylation (DD) of 63.6% exhibited the highest antibacterial activity, while the CMs with the DD of 83.7% exerted the lowest antibacterial activity among the three tested samples.

Original language	English
Pages (from-to)	214-220
Number of pages	7
Journal	Frontiers of Materials Science in China
Volume	2
Issue number	2
DOIs	https://doi.org/10.1007/s11706-008-0036-2
Publication status	Published - 2008 Jun

Keywords

Antibacterial activity
Chitosan
Dispersing system
Microsphere

ASJC Scopus subject areas

Materials Science(all)

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10.1007/s11706-008-0036-2

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title = "Preparation and antibacterial activity of chitosan microshperes in a solid dispersing system",

abstract = "In this study, we investigated the interface contacting inhibition behaviors of chitosan against bacterial in the dispersing state. For that purpose, chitosan microspheres (CMs) in the dispersing state was prepared by the emulsification cross-linking method. The CMs had smooth surface and spherical shape with the diameter of about 124 μm. They were stable after sterilization at 121°C and 150 kPa for 20 min. The CMs had similar antibacterial activity to that of chitosan in the solution form. Their antibacterial activities increased with the increase of the CM concentration, while decreased with the increase of pH of the system. It was found that the CMs with the degree of deacetylation (DD) of 63.6% exhibited the highest antibacterial activity, while the CMs with the DD of 83.7% exerted the lowest antibacterial activity among the three tested samples.",

keywords = "Antibacterial activity, Chitosan, Dispersing system, Microsphere",

author = "Ming Kong and Chen, {Xi Guang} and Xue, {Yu Ping} and Liu, {Cheng Sheng} and Yu, {Le Jun} and Ji, {Qiu Xia} and Cha, {Dong Su} and Park, {Hyun Jin}",

note = "Funding Information: Acknowledgements The authors are indebted to the financial support from the National Natural Science Foundation of China (Grant No. 30770582) and the International S&T Cooperation Program of China (NSFC No.2006DFA33150).",

year = "2008",

month = jun,

doi = "10.1007/s11706-008-0036-2",

language = "English",

volume = "2",

pages = "214--220",

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AU - Kong, Ming

AU - Chen, Xi Guang

AU - Xue, Yu Ping

AU - Liu, Cheng Sheng

AU - Yu, Le Jun

AU - Ji, Qiu Xia

AU - Cha, Dong Su

AU - Park, Hyun Jin

N1 - Funding Information: Acknowledgements The authors are indebted to the financial support from the National Natural Science Foundation of China (Grant No. 30770582) and the International S&T Cooperation Program of China (NSFC No.2006DFA33150).

PY - 2008/6

Y1 - 2008/6

N2 - In this study, we investigated the interface contacting inhibition behaviors of chitosan against bacterial in the dispersing state. For that purpose, chitosan microspheres (CMs) in the dispersing state was prepared by the emulsification cross-linking method. The CMs had smooth surface and spherical shape with the diameter of about 124 μm. They were stable after sterilization at 121°C and 150 kPa for 20 min. The CMs had similar antibacterial activity to that of chitosan in the solution form. Their antibacterial activities increased with the increase of the CM concentration, while decreased with the increase of pH of the system. It was found that the CMs with the degree of deacetylation (DD) of 63.6% exhibited the highest antibacterial activity, while the CMs with the DD of 83.7% exerted the lowest antibacterial activity among the three tested samples.

AB - In this study, we investigated the interface contacting inhibition behaviors of chitosan against bacterial in the dispersing state. For that purpose, chitosan microspheres (CMs) in the dispersing state was prepared by the emulsification cross-linking method. The CMs had smooth surface and spherical shape with the diameter of about 124 μm. They were stable after sterilization at 121°C and 150 kPa for 20 min. The CMs had similar antibacterial activity to that of chitosan in the solution form. Their antibacterial activities increased with the increase of the CM concentration, while decreased with the increase of pH of the system. It was found that the CMs with the degree of deacetylation (DD) of 63.6% exhibited the highest antibacterial activity, while the CMs with the DD of 83.7% exerted the lowest antibacterial activity among the three tested samples.

KW - Antibacterial activity

KW - Chitosan

KW - Dispersing system

KW - Microsphere

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JO - Frontiers of Materials Science

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ER -

Preparation and antibacterial activity of chitosan microshperes in a solid dispersing system

Abstract

Keywords

ASJC Scopus subject areas

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