Preparation and characteristics of a water-soluble chitosan-heparin complex

Dong Keon Kweon, Seung Taik Lim

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

To improve the wound-healing ability of chitosan, heparin, known to be effective in wound healing, was complexed with water-soluble chitosan (WSC) by chemical reaction. The chemical structure of the water-soluble chitosan-heparin (CH) complex was analyzed, and CH complex formation was confirmed with an FTIR spectrometer. The mechanical and thermal properties of the CH complex were measured by a tensile tester and thermal analyzers (DSC and TGA). Within the heparin content up to ≈470 IU/g in the aqueous CH complex solution, the intrinsic viscosity and tensile strength of the water-soluble CH complex gradually increased, but thermal stability slightly decreased by introducing the heparin into the WSC. When the heparin content was greater than these values (470 IU/g), the water-insoluble CH complex, which is supposed to have a multisubstituted or crosslinked structure, precipitated in the aqueous water-soluble CH complex solution.

Original languageEnglish
Pages (from-to)1784-1789
Number of pages6
JournalJournal of Applied Polymer Science
Volume87
Issue number11
DOIs
Publication statusPublished - 2003 Mar 14

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Chitosan
Heparin
Water
Spectrometers
Chemical reactions
Thermodynamic stability
Tensile strength
Thermodynamic properties
Viscosity
Mechanical properties

Keywords

  • Intrinsic viscosity
  • Tensile strength
  • Thermal property
  • Water-soluble chitosan-heparin complex

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Preparation and characteristics of a water-soluble chitosan-heparin complex. / Kweon, Dong Keon; Lim, Seung Taik.

In: Journal of Applied Polymer Science, Vol. 87, No. 11, 14.03.2003, p. 1784-1789.

Research output: Contribution to journalArticle

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