Preparation and characterization of drug-loaded polymethacrylate microspheres by an emulsion solvent evaporation method

B. K. Kim, S. J. Hwang, J. B. Park, Hyun Jin Park

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Microspheres containing the anti-hypertension drug, felodipine, were prepared by the emulsion solvent evaporation method (o/o) using acrylate methacrylate copolymers, Eudragit RL PO and Eudragit RS PO, as wall materials. In order to increase the encapsulation efficiency, a mixed solvent system comprising 1:1 proportions of acetonitrile and dichloromethane was used as a dispersed phase. The morphology of the microspheres was evaluated using a scanning electron microscope, which showed a spherical shape with smooth surface. The mean sphere diameter was between 9.5-13.2 μm and the microencapsulation efficiencies ranged from 51.4-80.4%. The release profiles and encapsulation efficiencies depended strongly on the structure of the polymers used as wall materials. The release rate of the Eudragit RS PO microspheres was much lower than that of Eudragit RL PO microspheres. Whereas Eudragit RL PO microspheres followed the Higuchi rule, Eudragit RS PO microspheres exhibited a triphasic release profile. It is concluded that drug release rate can be controlled by choice of polymer type.

Original languageEnglish
Pages (from-to)811-822
Number of pages12
JournalJournal of Microencapsulation
Volume19
Issue number6
DOIs
Publication statusPublished - 2002 Nov 1

Fingerprint

Drug Compounding
Emulsions
Microspheres
emulsions
Evaporation
drugs
evaporation
preparation
Pharmaceutical Preparations
hypertension
polymers
acrylates
profiles
Encapsulation
acetonitrile
copolymers
proportion
Polymers
electron microscopes
Felodipine

Keywords

  • Emulsion solvent evaporation
  • Eudragit
  • Felodipine
  • Microspheres
  • Mixed solvent system

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Pharmaceutical Science
  • Chemical Engineering(all)
  • Pharmacology

Cite this

Preparation and characterization of drug-loaded polymethacrylate microspheres by an emulsion solvent evaporation method. / Kim, B. K.; Hwang, S. J.; Park, J. B.; Park, Hyun Jin.

In: Journal of Microencapsulation, Vol. 19, No. 6, 01.11.2002, p. 811-822.

Research output: Contribution to journalArticle

@article{29df71b583c940f9b95caf4389b3a139,
title = "Preparation and characterization of drug-loaded polymethacrylate microspheres by an emulsion solvent evaporation method",
abstract = "Microspheres containing the anti-hypertension drug, felodipine, were prepared by the emulsion solvent evaporation method (o/o) using acrylate methacrylate copolymers, Eudragit RL PO and Eudragit RS PO, as wall materials. In order to increase the encapsulation efficiency, a mixed solvent system comprising 1:1 proportions of acetonitrile and dichloromethane was used as a dispersed phase. The morphology of the microspheres was evaluated using a scanning electron microscope, which showed a spherical shape with smooth surface. The mean sphere diameter was between 9.5-13.2 μm and the microencapsulation efficiencies ranged from 51.4-80.4{\%}. The release profiles and encapsulation efficiencies depended strongly on the structure of the polymers used as wall materials. The release rate of the Eudragit RS PO microspheres was much lower than that of Eudragit RL PO microspheres. Whereas Eudragit RL PO microspheres followed the Higuchi rule, Eudragit RS PO microspheres exhibited a triphasic release profile. It is concluded that drug release rate can be controlled by choice of polymer type.",
keywords = "Emulsion solvent evaporation, Eudragit, Felodipine, Microspheres, Mixed solvent system",
author = "Kim, {B. K.} and Hwang, {S. J.} and Park, {J. B.} and Park, {Hyun Jin}",
year = "2002",
month = "11",
day = "1",
doi = "10.1080/0265204021000022770",
language = "English",
volume = "19",
pages = "811--822",
journal = "Journal of Microencapsulation",
issn = "0265-2048",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Preparation and characterization of drug-loaded polymethacrylate microspheres by an emulsion solvent evaporation method

AU - Kim, B. K.

AU - Hwang, S. J.

AU - Park, J. B.

AU - Park, Hyun Jin

PY - 2002/11/1

Y1 - 2002/11/1

N2 - Microspheres containing the anti-hypertension drug, felodipine, were prepared by the emulsion solvent evaporation method (o/o) using acrylate methacrylate copolymers, Eudragit RL PO and Eudragit RS PO, as wall materials. In order to increase the encapsulation efficiency, a mixed solvent system comprising 1:1 proportions of acetonitrile and dichloromethane was used as a dispersed phase. The morphology of the microspheres was evaluated using a scanning electron microscope, which showed a spherical shape with smooth surface. The mean sphere diameter was between 9.5-13.2 μm and the microencapsulation efficiencies ranged from 51.4-80.4%. The release profiles and encapsulation efficiencies depended strongly on the structure of the polymers used as wall materials. The release rate of the Eudragit RS PO microspheres was much lower than that of Eudragit RL PO microspheres. Whereas Eudragit RL PO microspheres followed the Higuchi rule, Eudragit RS PO microspheres exhibited a triphasic release profile. It is concluded that drug release rate can be controlled by choice of polymer type.

AB - Microspheres containing the anti-hypertension drug, felodipine, were prepared by the emulsion solvent evaporation method (o/o) using acrylate methacrylate copolymers, Eudragit RL PO and Eudragit RS PO, as wall materials. In order to increase the encapsulation efficiency, a mixed solvent system comprising 1:1 proportions of acetonitrile and dichloromethane was used as a dispersed phase. The morphology of the microspheres was evaluated using a scanning electron microscope, which showed a spherical shape with smooth surface. The mean sphere diameter was between 9.5-13.2 μm and the microencapsulation efficiencies ranged from 51.4-80.4%. The release profiles and encapsulation efficiencies depended strongly on the structure of the polymers used as wall materials. The release rate of the Eudragit RS PO microspheres was much lower than that of Eudragit RL PO microspheres. Whereas Eudragit RL PO microspheres followed the Higuchi rule, Eudragit RS PO microspheres exhibited a triphasic release profile. It is concluded that drug release rate can be controlled by choice of polymer type.

KW - Emulsion solvent evaporation

KW - Eudragit

KW - Felodipine

KW - Microspheres

KW - Mixed solvent system

UR - http://www.scopus.com/inward/record.url?scp=0036875661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036875661&partnerID=8YFLogxK

U2 - 10.1080/0265204021000022770

DO - 10.1080/0265204021000022770

M3 - Article

C2 - 12569029

AN - SCOPUS:0036875661

VL - 19

SP - 811

EP - 822

JO - Journal of Microencapsulation

JF - Journal of Microencapsulation

SN - 0265-2048

IS - 6

ER -