Preparation and characterization of glycol chitin as a new thermogelling polymer for biomedical applications

Zhengzheng Li, Sungpil Cho, Ick Chan Kwon, Margit M. Janát-Amsbury, Kang Moo Huh

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

In this study, a new thermo-sensitive polymer, glycol chitin, was synthesized by controlled N-acetylation of glycol chitosan and evaluated as a thermogelling system. The physico-chemical properties of glycol chitins with different degrees of acetylation (DA) were investigated in terms of degradation, cytotoxicity, rheological properties, and in vitro and in vivo gel formation. Aqueous solutions of glycol chitins were flowable freely at room temperature but quickly became a durable gel at body temperature. Thermo-reversible sol-gel transition properties were observed with fast gelation kinetics. Glycol chitins with higher DA showed faster degradation in the presence of lysozyme. They exhibited no significant biological toxicity against human cell lines. An anti-cancer drug, doxorubicin, could be incorporated into the hydrogel by a simple mixing process and released in a sustained pattern over 13 days. Our findings suggest that glycol chitins could be useful as a new thermogelling biomaterial for drug delivery and injectable tissue engineering.

Original languageEnglish
Pages (from-to)2267-2275
Number of pages9
JournalCarbohydrate Polymers
Volume92
Issue number2
DOIs
Publication statusPublished - 2013 Feb 15
Externally publishedYes

Fingerprint

Chitin
Glycols
Polymers
Acetylation
Gels
Degradation
Hydrogel
Biocompatible Materials
Gelation
Cytotoxicity
Muramidase
Drug delivery
Tissue engineering
Doxorubicin
Chemical properties
Sol-gels
Toxicity
Chitosan
Biomaterials
Hydrogels

Keywords

  • Glycol chitin
  • Glycol chitosan
  • N-acetylation
  • Sol-gel transition
  • Thermogelling system

ASJC Scopus subject areas

  • Organic Chemistry
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Preparation and characterization of glycol chitin as a new thermogelling polymer for biomedical applications. / Li, Zhengzheng; Cho, Sungpil; Kwon, Ick Chan; Janát-Amsbury, Margit M.; Huh, Kang Moo.

In: Carbohydrate Polymers, Vol. 92, No. 2, 15.02.2013, p. 2267-2275.

Research output: Contribution to journalArticle

Li, Zhengzheng ; Cho, Sungpil ; Kwon, Ick Chan ; Janát-Amsbury, Margit M. ; Huh, Kang Moo. / Preparation and characterization of glycol chitin as a new thermogelling polymer for biomedical applications. In: Carbohydrate Polymers. 2013 ; Vol. 92, No. 2. pp. 2267-2275.
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