Preparation and release behavior of atorvastatin calcuim - Encapsulated polyoxalate microspheres

Cheon Jung Lee, Su Young Kim, Hyun Gu Lee, Jaewon Yang, Jin Young Park, Se Rom Cha, Dong-Kwon Lim, Dongwon Lee, Gilson Khang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Atorvastatin calcium-loaded polyoxalate (POX) microspheres were prepared by an emulsion solvent-evaporation/extraction method of oil-in-oil-in-water (O1/O2/W) for sustained release. We investigated the release behavior according to initial drug ratio, molecular weight (Mw) and concentration of POX and concentration of emulsifier. The microsphere was characterized on the surface, the cross-section morphology and the behavior of atorvastatin calcium release for 10 days by scanning electron microscopy (SEM) and high performance liquid chromatography (HPLC). The analysis of crystallization was analyzed to use X-ray diffraction (XRD), differential scanning calorimeter (DSC) and Fourier transform infrared (FTIR). These results showed that the release behaviors can be controlled by preparation conditions.

Original languageEnglish
Pages (from-to)656-663
Number of pages8
JournalPolymer (Korea)
Volume38
Issue number5
DOIs
Publication statusPublished - 2014 Sep 1
Externally publishedYes

Keywords

  • Atorvastatin calcium
  • Controlled release
  • Microsphere
  • O/O/W
  • Polyoxalate

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Polymers and Plastics
  • Materials Chemistry

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  • Cite this

    Lee, C. J., Kim, S. Y., Lee, H. G., Yang, J., Park, J. Y., Cha, S. R., Lim, D-K., Lee, D., & Khang, G. (2014). Preparation and release behavior of atorvastatin calcuim - Encapsulated polyoxalate microspheres. Polymer (Korea), 38(5), 656-663. https://doi.org/10.7317/pk.2014.38.5.656