Preparation and rheological properties of deoxycholate-chitosan and carboxymethyl-chitosan in aqueous systems

Hong Tao Pang; Xi Guang Chen; Hyun Jin Park; Dong Su Cha; John F. Kennedy

doi:10.1016/j.carbpol.2006.12.026

Preparation and rheological properties of deoxycholate-chitosan and carboxymethyl-chitosan in aqueous systems

Hong Tao Pang, Xi Guang Chen, Hyun Jin Park, Dong Su Cha, John F. Kennedy

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Self-aggregation and micelles of amphiphatic polymers are important functions in application, and their properties are influenced by the parent hydrophilic polymer and the hydrophobic groups. In this paper, deoxycholate-chitosan (DE-chitosan) and carboxymethyl-chitosan (CM-chitosan) were prepared from chitosan (MW, 28 kDa; DD, 90%). The effects of acid, pH and ionic concentrations on aggregation behaviors of the polymers in aqueous systems were measured, respectively. The ionic strength was found to enhance the aggregation of DE-chitosan, but had no influence to CM-chitosan and chitosan itself. The modification of hydrophobic groups and hydrophilic groups influenced the rheology properties of both parent chitosan and the derivatives. The assemblage of DE-chitosan in solution can be controlled by an oil/water (methylene chloride/DE-chitosan solution) emulsification process using methylene chloride. The micelles of DE-chitosan formed nano-micelles particles of 200-600 nm in diameter which can be used to encapsulate lipid-soluble compounds for drug dispersing and delivery releasing.

Original language	English
Pages (from-to)	419-425
Number of pages	7
Journal	Carbohydrate Polymers
Volume	69
Issue number	3
DOIs	https://doi.org/10.1016/j.carbpol.2006.12.026
Publication status	Published - 2007 Jun 25

Keywords

Chitosan
Micelle
Modification
Nanoparticle
Rheology

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2006.12.026

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title = "Preparation and rheological properties of deoxycholate-chitosan and carboxymethyl-chitosan in aqueous systems",

abstract = "Self-aggregation and micelles of amphiphatic polymers are important functions in application, and their properties are influenced by the parent hydrophilic polymer and the hydrophobic groups. In this paper, deoxycholate-chitosan (DE-chitosan) and carboxymethyl-chitosan (CM-chitosan) were prepared from chitosan (MW, 28 kDa; DD, 90%). The effects of acid, pH and ionic concentrations on aggregation behaviors of the polymers in aqueous systems were measured, respectively. The ionic strength was found to enhance the aggregation of DE-chitosan, but had no influence to CM-chitosan and chitosan itself. The modification of hydrophobic groups and hydrophilic groups influenced the rheology properties of both parent chitosan and the derivatives. The assemblage of DE-chitosan in solution can be controlled by an oil/water (methylene chloride/DE-chitosan solution) emulsification process using methylene chloride. The micelles of DE-chitosan formed nano-micelles particles of 200-600 nm in diameter which can be used to encapsulate lipid-soluble compounds for drug dispersing and delivery releasing.",

keywords = "Chitosan, Micelle, Modification, Nanoparticle, Rheology",

author = "Pang, {Hong Tao} and Chen, {Xi Guang} and Park, {Hyun Jin} and Cha, {Dong Su} and Kennedy, {John F.}",

note = "Funding Information: We acknowledge the ISTCP(2006DFA33150), NSFC (30670566) and KOSEF (1999-2-220-009-4) for the financial support in this study.",

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AU - Pang, Hong Tao

AU - Chen, Xi Guang

AU - Park, Hyun Jin

AU - Cha, Dong Su

AU - Kennedy, John F.

N1 - Funding Information: We acknowledge the ISTCP(2006DFA33150), NSFC (30670566) and KOSEF (1999-2-220-009-4) for the financial support in this study.

PY - 2007/6/25

Y1 - 2007/6/25

N2 - Self-aggregation and micelles of amphiphatic polymers are important functions in application, and their properties are influenced by the parent hydrophilic polymer and the hydrophobic groups. In this paper, deoxycholate-chitosan (DE-chitosan) and carboxymethyl-chitosan (CM-chitosan) were prepared from chitosan (MW, 28 kDa; DD, 90%). The effects of acid, pH and ionic concentrations on aggregation behaviors of the polymers in aqueous systems were measured, respectively. The ionic strength was found to enhance the aggregation of DE-chitosan, but had no influence to CM-chitosan and chitosan itself. The modification of hydrophobic groups and hydrophilic groups influenced the rheology properties of both parent chitosan and the derivatives. The assemblage of DE-chitosan in solution can be controlled by an oil/water (methylene chloride/DE-chitosan solution) emulsification process using methylene chloride. The micelles of DE-chitosan formed nano-micelles particles of 200-600 nm in diameter which can be used to encapsulate lipid-soluble compounds for drug dispersing and delivery releasing.

AB - Self-aggregation and micelles of amphiphatic polymers are important functions in application, and their properties are influenced by the parent hydrophilic polymer and the hydrophobic groups. In this paper, deoxycholate-chitosan (DE-chitosan) and carboxymethyl-chitosan (CM-chitosan) were prepared from chitosan (MW, 28 kDa; DD, 90%). The effects of acid, pH and ionic concentrations on aggregation behaviors of the polymers in aqueous systems were measured, respectively. The ionic strength was found to enhance the aggregation of DE-chitosan, but had no influence to CM-chitosan and chitosan itself. The modification of hydrophobic groups and hydrophilic groups influenced the rheology properties of both parent chitosan and the derivatives. The assemblage of DE-chitosan in solution can be controlled by an oil/water (methylene chloride/DE-chitosan solution) emulsification process using methylene chloride. The micelles of DE-chitosan formed nano-micelles particles of 200-600 nm in diameter which can be used to encapsulate lipid-soluble compounds for drug dispersing and delivery releasing.

KW - Chitosan

KW - Micelle

KW - Modification

KW - Nanoparticle

KW - Rheology

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Preparation and rheological properties of deoxycholate-chitosan and carboxymethyl-chitosan in aqueous systems

Abstract

Keywords

ASJC Scopus subject areas

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