Preparation and rheological properties of deoxycholate-chitosan and carboxymethyl-chitosan in aqueous systems

Hong Tao Pang, Xi Guang Chen, Hyun Jin Park, Dong S. Cha, John F. Kennedy

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Self-aggregation and micelles of amphiphatic polymers are important functions in application, and their properties are influenced by the parent hydrophilic polymer and the hydrophobic groups. In this paper, deoxycholate-chitosan (DE-chitosan) and carboxymethyl-chitosan (CM-chitosan) were prepared from chitosan (MW, 28 kDa; DD, 90%). The effects of acid, pH and ionic concentrations on aggregation behaviors of the polymers in aqueous systems were measured, respectively. The ionic strength was found to enhance the aggregation of DE-chitosan, but had no influence to CM-chitosan and chitosan itself. The modification of hydrophobic groups and hydrophilic groups influenced the rheology properties of both parent chitosan and the derivatives. The assemblage of DE-chitosan in solution can be controlled by an oil/water (methylene chloride/DE-chitosan solution) emulsification process using methylene chloride. The micelles of DE-chitosan formed nano-micelles particles of 200-600 nm in diameter which can be used to encapsulate lipid-soluble compounds for drug dispersing and delivery releasing.

Original languageEnglish
Pages (from-to)419-425
Number of pages7
JournalCarbohydrate Polymers
Volume69
Issue number3
DOIs
Publication statusPublished - 2007 Jun 25

Fingerprint

deoxycholic acid
Deoxycholic Acid
Chitosan
chitosan
rheological properties
Micelles
water
Polymers
Agglomeration
Methylene Chloride
micelles
Dichloromethane
methylene chloride
Emulsification
polymers
hydrophilic polymers
carboxymethyl-chitosan
Ionic strength
Rheology
aggregation behavior

Keywords

  • Chitosan
  • Micelle
  • Modification
  • Nanoparticle
  • Rheology

ASJC Scopus subject areas

  • Food Science
  • Biochemistry

Cite this

Preparation and rheological properties of deoxycholate-chitosan and carboxymethyl-chitosan in aqueous systems. / Pang, Hong Tao; Chen, Xi Guang; Park, Hyun Jin; Cha, Dong S.; Kennedy, John F.

In: Carbohydrate Polymers, Vol. 69, No. 3, 25.06.2007, p. 419-425.

Research output: Contribution to journalArticle

Pang, Hong Tao ; Chen, Xi Guang ; Park, Hyun Jin ; Cha, Dong S. ; Kennedy, John F. / Preparation and rheological properties of deoxycholate-chitosan and carboxymethyl-chitosan in aqueous systems. In: Carbohydrate Polymers. 2007 ; Vol. 69, No. 3. pp. 419-425.
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