Preparation of 2,3-diaminopropionate from ring opening of aziridine-2-carboxylate

Yongeun Kim, Hyun Joon Ha, Kyusung Han, Whan Ko Seung, Hoseop Yun, Jae Yoon Hyo, Sung Kim Min, Koo Lee Won

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Ring opening reaction of an enantiomerically pure aziridine-2-carboxylate with an azide nucleophile under aqueous acidic media proceeded efficiently and stereoselectively to give 3-amino-2-azidopropionate which is converted to orthogonally protected 2,3-diaminopropionate.

Original languageEnglish
Pages (from-to)4407-4409
Number of pages3
JournalTetrahedron Letters
Issue number25
Publication statusPublished - 2005 Jun 20
Externally publishedYes


  • 2,3-Diaminopropionate
  • Azide
  • Aziridine-2-carboxylate
  • Ring opening

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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