Preparation of 2,3-diaminopropionate from ring opening of aziridine-2-carboxylate

Yongeun Kim, Hyun Joon Ha, Kyusung Han, Whan Ko Seung, Hoseop Yun, Jae Yoon Hyo, Sung Kim Min, Koo Lee Won

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Ring opening reaction of an enantiomerically pure aziridine-2-carboxylate with an azide nucleophile under aqueous acidic media proceeded efficiently and stereoselectively to give 3-amino-2-azidopropionate which is converted to orthogonally protected 2,3-diaminopropionate.

Original languageEnglish
Pages (from-to)4407-4409
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number25
DOIs
Publication statusPublished - 2005 Jun 20

Keywords

  • 2,3-Diaminopropionate
  • Azide
  • Aziridine-2-carboxylate
  • Ring opening

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Kim, Y., Ha, H. J., Han, K., Seung, W. K., Yun, H., Hyo, J. Y., Min, S. K., & Won, K. L. (2005). Preparation of 2,3-diaminopropionate from ring opening of aziridine-2-carboxylate. Tetrahedron Letters, 46(25), 4407-4409. https://doi.org/10.1016/j.tetlet.2005.04.039