Abstract
Capsaicin o/w nanoemulsions with enhanced skin permeation were successfully prepared by controlling the ratios of the surfactant mixtures, oleoresin capsicum as the oil phase, and aqueous phase. Oleoresin capsicum contains 22.67 mg/g of capsaicin, which is an active and oil-soluble ingredient. Nonionic surfactants, Tween 80 and Span 80, were used to optimize the weight ratio of surfactant mixtures (85.98:14.02) by calculating the hydrophile-lipophile balance (HLB) value. The optimal processing conditions for stable nanoemulsions were investigated by using a ternary phase diagram. The mean droplet size of nanoemulsions ranged from 20 to 62 nm. Skin permeation studies were performed using a Franz diffusion cell. The permeation profiles and confocal laser scanning microscopy (CLSM) images supported that capsaicin nanoemulsion could well permeate all skin layers from the stratum corneum to the dermis. The selected nanoemulsions showed great potential as transdermal delivery carriers for enhancing the permeation of core materials.
| Original language | English |
|---|---|
| Pages (from-to) | 725-732 |
| Number of pages | 8 |
| Journal | Journal of Agricultural and Food Chemistry |
| Volume | 62 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2014 Jan 22 |
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Keywords
- capsaicin
- confocal microscopy
- HLB value
- nanoemulsion
- skin penetration
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Chemistry(all)
Cite this
Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration. / Kim, Jee Hye; Ko, Jung A.; Kim, Jun Tae; Cha, Dong Su; Cho, Jin Hun; Park, Hyun Jin; Shin, Gye Hwa.
In: Journal of Agricultural and Food Chemistry, Vol. 62, No. 3, 22.01.2014, p. 725-732.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration
AU - Kim, Jee Hye
AU - Ko, Jung A.
AU - Kim, Jun Tae
AU - Cha, Dong Su
AU - Cho, Jin Hun
AU - Park, Hyun Jin
AU - Shin, Gye Hwa
PY - 2014/1/22
Y1 - 2014/1/22
N2 - Capsaicin o/w nanoemulsions with enhanced skin permeation were successfully prepared by controlling the ratios of the surfactant mixtures, oleoresin capsicum as the oil phase, and aqueous phase. Oleoresin capsicum contains 22.67 mg/g of capsaicin, which is an active and oil-soluble ingredient. Nonionic surfactants, Tween 80 and Span 80, were used to optimize the weight ratio of surfactant mixtures (85.98:14.02) by calculating the hydrophile-lipophile balance (HLB) value. The optimal processing conditions for stable nanoemulsions were investigated by using a ternary phase diagram. The mean droplet size of nanoemulsions ranged from 20 to 62 nm. Skin permeation studies were performed using a Franz diffusion cell. The permeation profiles and confocal laser scanning microscopy (CLSM) images supported that capsaicin nanoemulsion could well permeate all skin layers from the stratum corneum to the dermis. The selected nanoemulsions showed great potential as transdermal delivery carriers for enhancing the permeation of core materials.
AB - Capsaicin o/w nanoemulsions with enhanced skin permeation were successfully prepared by controlling the ratios of the surfactant mixtures, oleoresin capsicum as the oil phase, and aqueous phase. Oleoresin capsicum contains 22.67 mg/g of capsaicin, which is an active and oil-soluble ingredient. Nonionic surfactants, Tween 80 and Span 80, were used to optimize the weight ratio of surfactant mixtures (85.98:14.02) by calculating the hydrophile-lipophile balance (HLB) value. The optimal processing conditions for stable nanoemulsions were investigated by using a ternary phase diagram. The mean droplet size of nanoemulsions ranged from 20 to 62 nm. Skin permeation studies were performed using a Franz diffusion cell. The permeation profiles and confocal laser scanning microscopy (CLSM) images supported that capsaicin nanoemulsion could well permeate all skin layers from the stratum corneum to the dermis. The selected nanoemulsions showed great potential as transdermal delivery carriers for enhancing the permeation of core materials.
KW - capsaicin
KW - confocal microscopy
KW - HLB value
KW - nanoemulsion
KW - skin penetration
UR - http://www.scopus.com/inward/record.url?scp=84892963630&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892963630&partnerID=8YFLogxK
U2 - 10.1021/jf404220n
DO - 10.1021/jf404220n
M3 - Article
C2 - 24417234
AN - SCOPUS:84892963630
VL - 62
SP - 725
EP - 732
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
SN - 0021-8561
IS - 3
ER -