Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration

Jee Hye Kim, Jung A. Ko, Jun Tae Kim, Dong Su Cha, Jin Hun Cho, Hyun Jin Park, Gye Hwa Shin

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Capsaicin o/w nanoemulsions with enhanced skin permeation were successfully prepared by controlling the ratios of the surfactant mixtures, oleoresin capsicum as the oil phase, and aqueous phase. Oleoresin capsicum contains 22.67 mg/g of capsaicin, which is an active and oil-soluble ingredient. Nonionic surfactants, Tween 80 and Span 80, were used to optimize the weight ratio of surfactant mixtures (85.98:14.02) by calculating the hydrophile-lipophile balance (HLB) value. The optimal processing conditions for stable nanoemulsions were investigated by using a ternary phase diagram. The mean droplet size of nanoemulsions ranged from 20 to 62 nm. Skin permeation studies were performed using a Franz diffusion cell. The permeation profiles and confocal laser scanning microscopy (CLSM) images supported that capsaicin nanoemulsion could well permeate all skin layers from the stratum corneum to the dermis. The selected nanoemulsions showed great potential as transdermal delivery carriers for enhancing the permeation of core materials.

Original languageEnglish
Pages (from-to)725-732
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume62
Issue number3
DOIs
Publication statusPublished - 2014 Jan 22

Fingerprint

nanoemulsions
capsaicin
Capsaicin
skin (animal)
Surface-Active Agents
Permeation
Skin
Oils
oleoresins
Capsicum
Polysorbates
surfactants
Dermis
Confocal Microscopy
Cornea
Nonionic surfactants
oils
nonionic surfactants
droplet size
permeates

Keywords

  • capsaicin
  • confocal microscopy
  • HLB value
  • nanoemulsion
  • skin penetration

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration. / Kim, Jee Hye; Ko, Jung A.; Kim, Jun Tae; Cha, Dong Su; Cho, Jin Hun; Park, Hyun Jin; Shin, Gye Hwa.

In: Journal of Agricultural and Food Chemistry, Vol. 62, No. 3, 22.01.2014, p. 725-732.

Research output: Contribution to journalArticle

Kim, Jee Hye ; Ko, Jung A. ; Kim, Jun Tae ; Cha, Dong Su ; Cho, Jin Hun ; Park, Hyun Jin ; Shin, Gye Hwa. / Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration. In: Journal of Agricultural and Food Chemistry. 2014 ; Vol. 62, No. 3. pp. 725-732.
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