Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration

Jee Hye Kim; Jung A. Ko; Jun Tae Kim; Dong Su Cha; Jin Hun Cho; Hyun Jin Park; Gye Hwa Shin

doi:10.1021/jf404220n

Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration

Jee Hye Kim, Jung A. Ko, Jun Tae Kim, Dong Su Cha, Jin Hun Cho, Hyun Jin Park, Gye Hwa Shin

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Capsaicin o/w nanoemulsions with enhanced skin permeation were successfully prepared by controlling the ratios of the surfactant mixtures, oleoresin capsicum as the oil phase, and aqueous phase. Oleoresin capsicum contains 22.67 mg/g of capsaicin, which is an active and oil-soluble ingredient. Nonionic surfactants, Tween 80 and Span 80, were used to optimize the weight ratio of surfactant mixtures (85.98:14.02) by calculating the hydrophile-lipophile balance (HLB) value. The optimal processing conditions for stable nanoemulsions were investigated by using a ternary phase diagram. The mean droplet size of nanoemulsions ranged from 20 to 62 nm. Skin permeation studies were performed using a Franz diffusion cell. The permeation profiles and confocal laser scanning microscopy (CLSM) images supported that capsaicin nanoemulsion could well permeate all skin layers from the stratum corneum to the dermis. The selected nanoemulsions showed great potential as transdermal delivery carriers for enhancing the permeation of core materials.

Original language	English
Pages (from-to)	725-732
Number of pages	8
Journal	Journal of agricultural and food chemistry
Volume	62
Issue number	3
DOIs	https://doi.org/10.1021/jf404220n
Publication status	Published - 2014 Jan 22

Keywords

HLB value
capsaicin
confocal microscopy
nanoemulsion
skin penetration

ASJC Scopus subject areas

Chemistry(all)
Agricultural and Biological Sciences(all)

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title = "Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration",

abstract = "Capsaicin o/w nanoemulsions with enhanced skin permeation were successfully prepared by controlling the ratios of the surfactant mixtures, oleoresin capsicum as the oil phase, and aqueous phase. Oleoresin capsicum contains 22.67 mg/g of capsaicin, which is an active and oil-soluble ingredient. Nonionic surfactants, Tween 80 and Span 80, were used to optimize the weight ratio of surfactant mixtures (85.98:14.02) by calculating the hydrophile-lipophile balance (HLB) value. The optimal processing conditions for stable nanoemulsions were investigated by using a ternary phase diagram. The mean droplet size of nanoemulsions ranged from 20 to 62 nm. Skin permeation studies were performed using a Franz diffusion cell. The permeation profiles and confocal laser scanning microscopy (CLSM) images supported that capsaicin nanoemulsion could well permeate all skin layers from the stratum corneum to the dermis. The selected nanoemulsions showed great potential as transdermal delivery carriers for enhancing the permeation of core materials.",

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author = "Kim, {Jee Hye} and Ko, {Jung A.} and Kim, {Jun Tae} and Cha, {Dong Su} and Cho, {Jin Hun} and Park, {Hyun Jin} and Shin, {Gye Hwa}",

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AU - Kim, Jun Tae

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AU - Cho, Jin Hun

AU - Park, Hyun Jin

AU - Shin, Gye Hwa

PY - 2014/1/22

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N2 - Capsaicin o/w nanoemulsions with enhanced skin permeation were successfully prepared by controlling the ratios of the surfactant mixtures, oleoresin capsicum as the oil phase, and aqueous phase. Oleoresin capsicum contains 22.67 mg/g of capsaicin, which is an active and oil-soluble ingredient. Nonionic surfactants, Tween 80 and Span 80, were used to optimize the weight ratio of surfactant mixtures (85.98:14.02) by calculating the hydrophile-lipophile balance (HLB) value. The optimal processing conditions for stable nanoemulsions were investigated by using a ternary phase diagram. The mean droplet size of nanoemulsions ranged from 20 to 62 nm. Skin permeation studies were performed using a Franz diffusion cell. The permeation profiles and confocal laser scanning microscopy (CLSM) images supported that capsaicin nanoemulsion could well permeate all skin layers from the stratum corneum to the dermis. The selected nanoemulsions showed great potential as transdermal delivery carriers for enhancing the permeation of core materials.

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