Preparation of acetylated chitosan sponges (Chitin Sponges)

Jung A. Ko, Bum Keun Kim, Hyun Jin Park

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Acetylated chitosan sponges (chitin sponges) were prepared according to acetylation time (25, 50, 75, and 100 h). As the acetylation time increased, the degree of acetylation increased, and a 75-h acetylation time produced the highest degree of acetylation (DA). The surface morphologies of samples were examined by scanning electron microscopy. Sponge samples were shown by a water uptake ability test to have higher water absorption abilities. An in vitro biodegradation test showed that sponges with a higher DA were more susceptible to lysozyme hydrolysis. Acetylated chitosan sponges were further shown by an in vitro fibroblast proliferation test to have a higher degree of cell viability on increasing the DA, with 75 h exhibiting the maximum effect. The results showed that the wound healing effect of chitosan sponges can be controlled by the DA.

Original languageEnglish
Pages (from-to)1618-1623
Number of pages6
JournalJournal of Applied Polymer Science
Volume117
Issue number3
DOIs
Publication statusPublished - 2010 Aug 1
Externally publishedYes

Keywords

  • Chitin
  • Chitosan
  • Degree of acetylation
  • Ound healing
  • Sponge

ASJC Scopus subject areas

  • Materials Chemistry
  • Polymers and Plastics
  • Surfaces, Coatings and Films
  • Chemistry(all)

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