Preparation of biodegradable microspheres containing water-soluble drug, β-lactam antibiotic

Jin Hee Kim, Ick Chan Kwon, Yong Hee Kim, Sung Bum La, Young Taek Sohn, Seo Young Jeong

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Poly (l-lactic acid) (PLLA) microspheres loaded with ampicillin sodium (AMP-Na), β-lactam antibiotic, were prepared by a w/o/w multiple emulsion-solvent evaporation method. The amounts of each component in three phases (inner water phase, organic phase, and outer water phase) were carefully examined in the preparation of PLLA microspheres. The stirring rate, another preparation parameter, was also investigated for study on the effect of mechanical stress on the drug loading and morphology of PLLA microspheres. Most of the preparation parameters had a great influence on the drug loading, surface morphology and size distribution of PLLA microspheres. PLLA microspheres with 15.89 w/w% drug loading were subjected to the in vitro release experiment. The release of ampicillin sodium was constant at a rate of 1.68 μg/ml/day per 1 mg of microspheres for 18 days after a 4 days initial burst effect.

Original languageEnglish
Pages (from-to)30-35
Number of pages6
JournalArchives of Pharmacal Research
Volume19
Issue number1
Publication statusPublished - 1996 Dec 1
Externally publishedYes

Fingerprint

Lactams
Microspheres
Lactic Acid
Anti-Bacterial Agents
Water
Pharmaceutical Preparations
Ampicillin
Mechanical Stress
Adenosine Monophosphate
Emulsions
Surface morphology
Evaporation
poly(lactic acid)

Keywords

  • Ampicillin sodium
  • Antibiotics
  • Microspheres
  • Poly (l-lactic acid)
  • Solvent evaporation
  • w/o/w emulsion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Kim, J. H., Kwon, I. C., Kim, Y. H., La, S. B., Sohn, Y. T., & Jeong, S. Y. (1996). Preparation of biodegradable microspheres containing water-soluble drug, β-lactam antibiotic. Archives of Pharmacal Research, 19(1), 30-35.

Preparation of biodegradable microspheres containing water-soluble drug, β-lactam antibiotic. / Kim, Jin Hee; Kwon, Ick Chan; Kim, Yong Hee; La, Sung Bum; Sohn, Young Taek; Jeong, Seo Young.

In: Archives of Pharmacal Research, Vol. 19, No. 1, 01.12.1996, p. 30-35.

Research output: Contribution to journalArticle

Kim, JH, Kwon, IC, Kim, YH, La, SB, Sohn, YT & Jeong, SY 1996, 'Preparation of biodegradable microspheres containing water-soluble drug, β-lactam antibiotic', Archives of Pharmacal Research, vol. 19, no. 1, pp. 30-35.
Kim, Jin Hee ; Kwon, Ick Chan ; Kim, Yong Hee ; La, Sung Bum ; Sohn, Young Taek ; Jeong, Seo Young. / Preparation of biodegradable microspheres containing water-soluble drug, β-lactam antibiotic. In: Archives of Pharmacal Research. 1996 ; Vol. 19, No. 1. pp. 30-35.
@article{affac8b6925f45db848794caa8e8f254,
title = "Preparation of biodegradable microspheres containing water-soluble drug, β-lactam antibiotic",
abstract = "Poly (l-lactic acid) (PLLA) microspheres loaded with ampicillin sodium (AMP-Na), β-lactam antibiotic, were prepared by a w/o/w multiple emulsion-solvent evaporation method. The amounts of each component in three phases (inner water phase, organic phase, and outer water phase) were carefully examined in the preparation of PLLA microspheres. The stirring rate, another preparation parameter, was also investigated for study on the effect of mechanical stress on the drug loading and morphology of PLLA microspheres. Most of the preparation parameters had a great influence on the drug loading, surface morphology and size distribution of PLLA microspheres. PLLA microspheres with 15.89 w/w{\%} drug loading were subjected to the in vitro release experiment. The release of ampicillin sodium was constant at a rate of 1.68 μg/ml/day per 1 mg of microspheres for 18 days after a 4 days initial burst effect.",
keywords = "Ampicillin sodium, Antibiotics, Microspheres, Poly (l-lactic acid), Solvent evaporation, w/o/w emulsion",
author = "Kim, {Jin Hee} and Kwon, {Ick Chan} and Kim, {Yong Hee} and La, {Sung Bum} and Sohn, {Young Taek} and Jeong, {Seo Young}",
year = "1996",
month = "12",
day = "1",
language = "English",
volume = "19",
pages = "30--35",
journal = "Archives of Pharmacal Research",
issn = "0253-6269",
publisher = "Pharmaceutical Society of Korea",
number = "1",

}

TY - JOUR

T1 - Preparation of biodegradable microspheres containing water-soluble drug, β-lactam antibiotic

AU - Kim, Jin Hee

AU - Kwon, Ick Chan

AU - Kim, Yong Hee

AU - La, Sung Bum

AU - Sohn, Young Taek

AU - Jeong, Seo Young

PY - 1996/12/1

Y1 - 1996/12/1

N2 - Poly (l-lactic acid) (PLLA) microspheres loaded with ampicillin sodium (AMP-Na), β-lactam antibiotic, were prepared by a w/o/w multiple emulsion-solvent evaporation method. The amounts of each component in three phases (inner water phase, organic phase, and outer water phase) were carefully examined in the preparation of PLLA microspheres. The stirring rate, another preparation parameter, was also investigated for study on the effect of mechanical stress on the drug loading and morphology of PLLA microspheres. Most of the preparation parameters had a great influence on the drug loading, surface morphology and size distribution of PLLA microspheres. PLLA microspheres with 15.89 w/w% drug loading were subjected to the in vitro release experiment. The release of ampicillin sodium was constant at a rate of 1.68 μg/ml/day per 1 mg of microspheres for 18 days after a 4 days initial burst effect.

AB - Poly (l-lactic acid) (PLLA) microspheres loaded with ampicillin sodium (AMP-Na), β-lactam antibiotic, were prepared by a w/o/w multiple emulsion-solvent evaporation method. The amounts of each component in three phases (inner water phase, organic phase, and outer water phase) were carefully examined in the preparation of PLLA microspheres. The stirring rate, another preparation parameter, was also investigated for study on the effect of mechanical stress on the drug loading and morphology of PLLA microspheres. Most of the preparation parameters had a great influence on the drug loading, surface morphology and size distribution of PLLA microspheres. PLLA microspheres with 15.89 w/w% drug loading were subjected to the in vitro release experiment. The release of ampicillin sodium was constant at a rate of 1.68 μg/ml/day per 1 mg of microspheres for 18 days after a 4 days initial burst effect.

KW - Ampicillin sodium

KW - Antibiotics

KW - Microspheres

KW - Poly (l-lactic acid)

KW - Solvent evaporation

KW - w/o/w emulsion

UR - http://www.scopus.com/inward/record.url?scp=0030428917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030428917&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0030428917

VL - 19

SP - 30

EP - 35

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

SN - 0253-6269

IS - 1

ER -