Abstract
Diisononyl adipate is a plasticizer which has excellent property of low temperature resistance and is permitted in food contact materials. In this study, diisononyl adipate was synthesized from adipic acid and isononyl alcohol in a solvent-free system via immobilized lipase-catalyzed esterification. Liquid Eversa lipase from Thermomyces lanuginosus was immobilized on Lewatit VP OC 1600 carrier. The effects of temperature, substrate molar ratio, water activity of enzyme, vacuum, and enzyme loading on the reaction efficiency were investigated. Application of vacuum played a key role to achieve a 100% conversion. The optimal temperature, molar ratio (adipic acid to isononyl alcohol), water activity of enzyme, vacuum were 50 °C, 1:3, 0.75, 13.3 kPa, and 10% (based on weight of total substrate). Under these conditions, 100% conversion was achieved within 6 h.
| Original language | English |
|---|---|
| Journal | Enzyme and Microbial Technology |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
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Keywords
- Adipic acid
- Diisononyl adipate
- Esterification
- Eversa lipase
- Isononyl alcohol
- Plasticizer
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biochemistry
- Applied Microbiology and Biotechnology
Cite this
Preparation of diisononyl adipate in a solvent-free system via an immobilized lipase-catalyzed esterification. / Lee, Aree; Kim, Heejin; Choi, Nakyung; Yoon, Sung Won; Kim, Yangha; Kim, Hak Ryul; Kim, In-Hwan.
In: Enzyme and Microbial Technology, 01.01.2019.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Preparation of diisononyl adipate in a solvent-free system via an immobilized lipase-catalyzed esterification
AU - Lee, Aree
AU - Kim, Heejin
AU - Choi, Nakyung
AU - Yoon, Sung Won
AU - Kim, Yangha
AU - Kim, Hak Ryul
AU - Kim, In-Hwan
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Diisononyl adipate is a plasticizer which has excellent property of low temperature resistance and is permitted in food contact materials. In this study, diisononyl adipate was synthesized from adipic acid and isononyl alcohol in a solvent-free system via immobilized lipase-catalyzed esterification. Liquid Eversa lipase from Thermomyces lanuginosus was immobilized on Lewatit VP OC 1600 carrier. The effects of temperature, substrate molar ratio, water activity of enzyme, vacuum, and enzyme loading on the reaction efficiency were investigated. Application of vacuum played a key role to achieve a 100% conversion. The optimal temperature, molar ratio (adipic acid to isononyl alcohol), water activity of enzyme, vacuum were 50 °C, 1:3, 0.75, 13.3 kPa, and 10% (based on weight of total substrate). Under these conditions, 100% conversion was achieved within 6 h.
AB - Diisononyl adipate is a plasticizer which has excellent property of low temperature resistance and is permitted in food contact materials. In this study, diisononyl adipate was synthesized from adipic acid and isononyl alcohol in a solvent-free system via immobilized lipase-catalyzed esterification. Liquid Eversa lipase from Thermomyces lanuginosus was immobilized on Lewatit VP OC 1600 carrier. The effects of temperature, substrate molar ratio, water activity of enzyme, vacuum, and enzyme loading on the reaction efficiency were investigated. Application of vacuum played a key role to achieve a 100% conversion. The optimal temperature, molar ratio (adipic acid to isononyl alcohol), water activity of enzyme, vacuum were 50 °C, 1:3, 0.75, 13.3 kPa, and 10% (based on weight of total substrate). Under these conditions, 100% conversion was achieved within 6 h.
KW - Adipic acid
KW - Diisononyl adipate
KW - Esterification
KW - Eversa lipase
KW - Isononyl alcohol
KW - Plasticizer
UR - http://www.scopus.com/inward/record.url?scp=85064986503&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064986503&partnerID=8YFLogxK
U2 - 10.1016/j.enzmictec.2019.04.014
DO - 10.1016/j.enzmictec.2019.04.014
M3 - Article
AN - SCOPUS:85064986503
JO - Enzyme and Microbial Technology
JF - Enzyme and Microbial Technology
SN - 0141-0229
ER -