Preparation of electrospun poly(l-lactide-co-caprolactone-co-glycolide)/phospholipid polymer/rapamycin blended fibers for vascular application

Hyung Il Kim, Ryosuke Matsuno, Ji-Hun Seo, Tomohiro Konno, Madoka Takai, Kazuhiko Ishihara

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Nanopores generated from the gap among electrospun nanofibers can provide vascular tissues with oxygen, nutrients, and growth factors. Here, we report the first fabrication of poly(l-lactide-co-caprolactone-co-glycolide) (PLCG) electrospun nanofibers. A water-soluble amphiphilic copolymer bearing phosphorylcholine groups (PMB30W) and an antiproliferative (rapamycin) were incorporated into PLCG by solvent blending and subsequent electrospinning. The nanostructure of the electrospun PLCG/PMB30W/rapamycin blended fibers was stable during incubation in phosphate-buffered saline without addition of chemical crosslinkers. Amphiphilic characteristics of PMB30W and hydrophobic nature of rapamycin could make the electrospun PLCG/PMB30W/rapamycin blended fibers stable under a physiologic condition. The electrospun PLCG/PMB30W/rapamycin blended fibers may be preferable for vascular prostheses and tissue-engineered vascular grafts.

Original languageEnglish
JournalCurrent Applied Physics
Volume9
Issue number4 SUPPL.
DOIs
Publication statusPublished - 2009 Jul 1
Externally publishedYes

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Keywords

  • Artificial vessels
  • Electrospinning
  • Phospholipid polymer
  • poly(l-lactide-co-caprolactone-co-glycolide)
  • Rapamycin

ASJC Scopus subject areas

  • Materials Science(all)
  • Physics and Astronomy(all)

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