Preparation of encapsulated alliinase in alginate microparticles

J. A. Ko, Y. L. Lee, H. J. Jeong, Hyun Jin Park

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Alliinase (alkylsulphenate lyase, EC 4. 4. 1. 4), which catalyses the production of allicin, was immobilized in alginate microparticles. Addition of pyridoxal 5′-phosphate to the microparticles enhanced alliinase activity. Encapsulated alliinase were significantly higher (30 and 22%, respectively) than those of non-encapsulated alliinase at 60°C and at pH 2. Therefore, microencapsulation of alliinase with alginate can offer an effective way of sustaining enzyme activity during oral administration and passage through the stomach.

Original languageEnglish
Pages (from-to)515-518
Number of pages4
JournalBiotechnology Letters
Volume34
Issue number3
DOIs
Publication statusPublished - 2012 Mar 1

Fingerprint

alliin lyase
Drug Compounding
Lyases
Pyridoxal Phosphate
Oral Administration
Stomach
alginic acid
Enzymes

Keywords

  • Alliinase
  • Encapsulation
  • Garlic
  • Microparticles

ASJC Scopus subject areas

  • Biotechnology

Cite this

Preparation of encapsulated alliinase in alginate microparticles. / Ko, J. A.; Lee, Y. L.; Jeong, H. J.; Park, Hyun Jin.

In: Biotechnology Letters, Vol. 34, No. 3, 01.03.2012, p. 515-518.

Research output: Contribution to journalArticle

Ko, J. A. ; Lee, Y. L. ; Jeong, H. J. ; Park, Hyun Jin. / Preparation of encapsulated alliinase in alginate microparticles. In: Biotechnology Letters. 2012 ; Vol. 34, No. 3. pp. 515-518.
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