Preparation of enhanced hydrophobic poly(l-lactide-co-ε-caprolactone) films surface and its blood compatibility

Seung Il Kim, Jin Ik Lim, Youngmee Jung, Cho Hay Mun, Ji Heung Kim, Soo Hyun Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Hydrophobicity-enhanced poly(l-lactide-co-ε-caprolactone) (PLCL) (50:50) films were cast by using the solvent-nonsolvent casting method. PLCL (50:50) was synthesized by the well-known random copolymerization process and confirmed by 1H NMR analysis. The molecular weight of the synthesized PLCL was measured by gel permeation chromatography (GPC). Number-average (Mn), weight-average (Mw) molecular weights and polydispersity (Mw/Mn) were 7 × 104, 1.2 × 105, and 1.7, respectively. PLCL films were cast in vacuum condition with various nonsolvents and nonsolvent ratios. Tetrahydrofuran (THF) was used as the solvent and three different alcohols were used as the nonsolvent: methanol, ethanol, and isopropyl alcohol (IPA). Surface hydrophobicity was confirmed by water contact angle. The water contact angle was increased from 81 ± 2 to 107 ± 2. Water contact angle was influenced by surface porosity and topography. The prepared film surfaces were characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The change of crystalline property was characterized by X-ray diffraction (XRD). Platelet adhesion tests on the modified PLCL film surfaces were evaluated by platelet-rich plasma (PRP). The modified film surface exhibited enhanced hydrophobicity and reduced platelet adhesion ratio depending on the surface topography. One of the candidate products proposed as a potential blood compatible material showed a markedly reduced platelet adhesion property.

Original languageEnglish
Pages (from-to)586-591
Number of pages6
JournalApplied Surface Science
Volume276
DOIs
Publication statusPublished - 2013 Jul 1

Fingerprint

Platelets
Blood
Hydrophobicity
Contact angle
Adhesion
Water
Alcohols
Molecular weight
2-Propanol
Gel permeation chromatography
Polydispersity
Surface topography
Copolymerization
Topography
Methanol
Atomic force microscopy
Casting
Ethanol
Porosity
Nuclear magnetic resonance

Keywords

  • Blood
  • compatibility
  • Hydrophobicity
  • PLCL
  • Porous material
  • Surface modification

ASJC Scopus subject areas

  • Surfaces, Coatings and Films

Cite this

Preparation of enhanced hydrophobic poly(l-lactide-co-ε-caprolactone) films surface and its blood compatibility. / Kim, Seung Il; Lim, Jin Ik; Jung, Youngmee; Mun, Cho Hay; Kim, Ji Heung; Kim, Soo Hyun.

In: Applied Surface Science, Vol. 276, 01.07.2013, p. 586-591.

Research output: Contribution to journalArticle

Kim, Seung Il ; Lim, Jin Ik ; Jung, Youngmee ; Mun, Cho Hay ; Kim, Ji Heung ; Kim, Soo Hyun. / Preparation of enhanced hydrophobic poly(l-lactide-co-ε-caprolactone) films surface and its blood compatibility. In: Applied Surface Science. 2013 ; Vol. 276. pp. 586-591.
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