Preparation of sodium alginate microspheres containing hydrophilic β-lactam antibiotics

Kyung Hee Chun, Ick Chan Kwon, Yong Hee Kim, Sung Bum La, Young Taek Sohn, Seo Young Jeong

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Alginate microspheres were prepared by the emulsification process as a drug delivery system of ampicillin sodium (AMP-Na). The preparation parameters such as the concentration of calcium chloride, the stirring time and the amount of AMP-Na were investigated. The alginate microspheres containing hydroxypropylmethylcellulose (HPMC) were found to be generally spherical, discrete and had smoother surfaces when compared to without HPMC. However, there was no significant difference in the release profile of AMP-Na from alginate microspheres prepared with or without HPMC. The concentration of calcium chloride solution and the stirring time in the preparation of alginate microspheres influenced the aggregation of alginate microspheres. The amount of AMP-Na in alginate microspheres influenced the sur face morphology and the practical drug content in microspheres.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalArchives of pharmacal research
Volume19
Issue number2
DOIs
Publication statusPublished - 1996

Keywords

  • Ampicillin sodium
  • Controlled release
  • Microspheres
  • Sodium alginate

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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