Abstract
Sustained release microspheres containing phenylpropanolamine HCl (PPA) were prepared with acrylic polymer (Eudragit RL/RS) sand hydroxypropylmethylcellulose phthalate (HPMCP) using a emulsion-solvent evaporation method. Magnesium stearate was used a smoothing agent for preparation of microspheres. The microspheres obtained were very spherical and free-flowing particles. Scanning electron microscopy showed that microspheres have a smooth surface and a sponge-like internal structure. The dissolution rate of PPA from the microspheres was dependent on the pH of dissolution media. PPA showed faster release in pH 1.2 solution than in pH 7.4 solution due to the solubility of PPA. Therefore we prepared new microspheres containing 5% (w/v) HPMCP in order to control the release of PPA. The release rate of PPA from these new microspheres was similar in pH 1.2 and pH 7.4 solution.
| Original language | English |
|---|---|
| Pages (from-to) | 293-297 |
| Number of pages | 5 |
| Journal | Archives of Pharmacal Research |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1990 Dec |
| Externally published | Yes |
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Keywords
- dissolution
- Eudragit RL/RS
- HPMCP
- microencapsulation
- Phenylpropanolamine HCl
- solvent evaporation method
- sustained-release
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery
- Organic Chemistry
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Preparation of substained-release microspheres of phenylpropanolamine HCl and their release characteristics. / Kim, Chong Kook; Lee, Kyung-Mi; Hwang, Sung Joo; Yoon, Yong Sang.
In: Archives of Pharmacal Research, Vol. 13, No. 4, 12.1990, p. 293-297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Preparation of substained-release microspheres of phenylpropanolamine HCl and their release characteristics
AU - Kim, Chong Kook
AU - Lee, Kyung-Mi
AU - Hwang, Sung Joo
AU - Yoon, Yong Sang
PY - 1990/12
Y1 - 1990/12
N2 - Sustained release microspheres containing phenylpropanolamine HCl (PPA) were prepared with acrylic polymer (Eudragit RL/RS) sand hydroxypropylmethylcellulose phthalate (HPMCP) using a emulsion-solvent evaporation method. Magnesium stearate was used a smoothing agent for preparation of microspheres. The microspheres obtained were very spherical and free-flowing particles. Scanning electron microscopy showed that microspheres have a smooth surface and a sponge-like internal structure. The dissolution rate of PPA from the microspheres was dependent on the pH of dissolution media. PPA showed faster release in pH 1.2 solution than in pH 7.4 solution due to the solubility of PPA. Therefore we prepared new microspheres containing 5% (w/v) HPMCP in order to control the release of PPA. The release rate of PPA from these new microspheres was similar in pH 1.2 and pH 7.4 solution.
AB - Sustained release microspheres containing phenylpropanolamine HCl (PPA) were prepared with acrylic polymer (Eudragit RL/RS) sand hydroxypropylmethylcellulose phthalate (HPMCP) using a emulsion-solvent evaporation method. Magnesium stearate was used a smoothing agent for preparation of microspheres. The microspheres obtained were very spherical and free-flowing particles. Scanning electron microscopy showed that microspheres have a smooth surface and a sponge-like internal structure. The dissolution rate of PPA from the microspheres was dependent on the pH of dissolution media. PPA showed faster release in pH 1.2 solution than in pH 7.4 solution due to the solubility of PPA. Therefore we prepared new microspheres containing 5% (w/v) HPMCP in order to control the release of PPA. The release rate of PPA from these new microspheres was similar in pH 1.2 and pH 7.4 solution.
KW - dissolution
KW - Eudragit RL/RS
KW - HPMCP
KW - microencapsulation
KW - Phenylpropanolamine HCl
KW - solvent evaporation method
KW - sustained-release
UR - http://www.scopus.com/inward/record.url?scp=0025645773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025645773&partnerID=8YFLogxK
U2 - 10.1007/BF02858161
DO - 10.1007/BF02858161
M3 - Article
VL - 13
SP - 293
EP - 297
JO - Archives of Pharmacal Research
JF - Archives of Pharmacal Research
SN - 0253-6269
IS - 4
ER -