Preparation of substained-release microspheres of phenylpropanolamine HCl and their release characteristics

Chong Kook Kim; Kyung Mi Lee; Sung Joo Hwang; Yong Sang Yoon

doi:10.1007/BF02858161

Preparation of substained-release microspheres of phenylpropanolamine HCl and their release characteristics

Chong Kook Kim, Kyung Mi Lee, Sung Joo Hwang, Yong Sang Yoon

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Sustained release microspheres containing phenylpropanolamine HCl (PPA) were prepared with acrylic polymer (Eudragit RL/RS) sand hydroxypropylmethylcellulose phthalate (HPMCP) using a emulsion-solvent evaporation method. Magnesium stearate was used a smoothing agent for preparation of microspheres. The microspheres obtained were very spherical and free-flowing particles. Scanning electron microscopy showed that microspheres have a smooth surface and a sponge-like internal structure. The dissolution rate of PPA from the microspheres was dependent on the pH of dissolution media. PPA showed faster release in pH 1.2 solution than in pH 7.4 solution due to the solubility of PPA. Therefore we prepared new microspheres containing 5% (w/v) HPMCP in order to control the release of PPA. The release rate of PPA from these new microspheres was similar in pH 1.2 and pH 7.4 solution.

Original language	English
Pages (from-to)	293-297
Number of pages	5
Journal	Archives of pharmacal research
Volume	13
Issue number	4
DOIs	https://doi.org/10.1007/BF02858161
Publication status	Published - 1990 Dec
Externally published	Yes

Keywords

Eudragit RL/RS
HPMCP
Phenylpropanolamine HCl
dissolution
microencapsulation
solvent evaporation method
sustained-release

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/BF02858161

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Kim, C. K., Lee, K. M., Hwang, S. J., & Yoon, Y. S. (1990). Preparation of substained-release microspheres of phenylpropanolamine HCl and their release characteristics. Archives of pharmacal research, 13(4), 293-297. https://doi.org/10.1007/BF02858161

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abstract = "Sustained release microspheres containing phenylpropanolamine HCl (PPA) were prepared with acrylic polymer (Eudragit RL/RS) sand hydroxypropylmethylcellulose phthalate (HPMCP) using a emulsion-solvent evaporation method. Magnesium stearate was used a smoothing agent for preparation of microspheres. The microspheres obtained were very spherical and free-flowing particles. Scanning electron microscopy showed that microspheres have a smooth surface and a sponge-like internal structure. The dissolution rate of PPA from the microspheres was dependent on the pH of dissolution media. PPA showed faster release in pH 1.2 solution than in pH 7.4 solution due to the solubility of PPA. Therefore we prepared new microspheres containing 5% (w/v) HPMCP in order to control the release of PPA. The release rate of PPA from these new microspheres was similar in pH 1.2 and pH 7.4 solution.",

keywords = "Eudragit RL/RS, HPMCP, Phenylpropanolamine HCl, dissolution, microencapsulation, solvent evaporation method, sustained-release",

author = "Kim, {Chong Kook} and Lee, {Kyung Mi} and Hwang, {Sung Joo} and Yoon, {Yong Sang}",

year = "1990",

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doi = "10.1007/BF02858161",

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AU - Kim, Chong Kook

AU - Lee, Kyung Mi

AU - Hwang, Sung Joo

AU - Yoon, Yong Sang

PY - 1990/12

Y1 - 1990/12

N2 - Sustained release microspheres containing phenylpropanolamine HCl (PPA) were prepared with acrylic polymer (Eudragit RL/RS) sand hydroxypropylmethylcellulose phthalate (HPMCP) using a emulsion-solvent evaporation method. Magnesium stearate was used a smoothing agent for preparation of microspheres. The microspheres obtained were very spherical and free-flowing particles. Scanning electron microscopy showed that microspheres have a smooth surface and a sponge-like internal structure. The dissolution rate of PPA from the microspheres was dependent on the pH of dissolution media. PPA showed faster release in pH 1.2 solution than in pH 7.4 solution due to the solubility of PPA. Therefore we prepared new microspheres containing 5% (w/v) HPMCP in order to control the release of PPA. The release rate of PPA from these new microspheres was similar in pH 1.2 and pH 7.4 solution.

AB - Sustained release microspheres containing phenylpropanolamine HCl (PPA) were prepared with acrylic polymer (Eudragit RL/RS) sand hydroxypropylmethylcellulose phthalate (HPMCP) using a emulsion-solvent evaporation method. Magnesium stearate was used a smoothing agent for preparation of microspheres. The microspheres obtained were very spherical and free-flowing particles. Scanning electron microscopy showed that microspheres have a smooth surface and a sponge-like internal structure. The dissolution rate of PPA from the microspheres was dependent on the pH of dissolution media. PPA showed faster release in pH 1.2 solution than in pH 7.4 solution due to the solubility of PPA. Therefore we prepared new microspheres containing 5% (w/v) HPMCP in order to control the release of PPA. The release rate of PPA from these new microspheres was similar in pH 1.2 and pH 7.4 solution.

KW - Eudragit RL/RS

KW - HPMCP

KW - Phenylpropanolamine HCl

KW - dissolution

KW - microencapsulation

KW - solvent evaporation method

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