Preparation of substained-release microspheres of phenylpropanolamine HCl and their release characteristics

Chong Kook Kim, Kyung Mi Lee, Sung Joo Hwang, Yong Sang Yoon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Sustained release microspheres containing phenylpropanolamine HCl (PPA) were prepared with acrylic polymer (Eudragit RL/RS) sand hydroxypropylmethylcellulose phthalate (HPMCP) using a emulsion-solvent evaporation method. Magnesium stearate was used a smoothing agent for preparation of microspheres. The microspheres obtained were very spherical and free-flowing particles. Scanning electron microscopy showed that microspheres have a smooth surface and a sponge-like internal structure. The dissolution rate of PPA from the microspheres was dependent on the pH of dissolution media. PPA showed faster release in pH 1.2 solution than in pH 7.4 solution due to the solubility of PPA. Therefore we prepared new microspheres containing 5% (w/v) HPMCP in order to control the release of PPA. The release rate of PPA from these new microspheres was similar in pH 1.2 and pH 7.4 solution.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalArchives of pharmacal research
Volume13
Issue number4
DOIs
Publication statusPublished - 1990 Dec
Externally publishedYes

Keywords

  • Eudragit RL/RS
  • HPMCP
  • Phenylpropanolamine HCl
  • dissolution
  • microencapsulation
  • solvent evaporation method
  • sustained-release

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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