Preproghrelin Leu72Met polymorphism in obese Korean children

Dae Sun Jo, Se Lim Kim, Sun Young Kim, Pyoung Han Hwang, Kee Hyoung Lee, Dae Yoel Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Ghrelin is a novel gut-brain peptide that has somatotropic, orexigenic, and adipogenic effects. We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. No significant difference was found between Met72 carrier and non-carrier obese children with respect to BMI, total body fat, serum triglycerides, total cholesterol, or LDL-cholesterol levels. Our data suggest that the preproghrelin Leu72Met polymorphism is not associated with obesity in children.

Original languageEnglish
Pages (from-to)1083-1086
Number of pages4
JournalJournal of Pediatric Endocrinology and Metabolism
Volume18
Issue number11
Publication statusPublished - 2005 Nov 1

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Keywords

  • Children
  • Ghrelin
  • Leu72Met polymorphism
  • Obesity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Jo, D. S., Kim, S. L., Kim, S. Y., Hwang, P. H., Lee, K. H., & Lee, D. Y. (2005). Preproghrelin Leu72Met polymorphism in obese Korean children. Journal of Pediatric Endocrinology and Metabolism, 18(11), 1083-1086.