Preproghrelin Leu72Met polymorphism in obese Korean children

Dae Sun Jo; Se Lim Kim; Sun Young Kim; Pyoung Han Hwang; Kee Houng Lee; Dae Yoel Lee

doi:10.1515/JPEM.2005.18.11.1083

Preproghrelin Leu72Met polymorphism in obese Korean children

Dae Sun Jo, Se Lim Kim, Sun Young Kim, Pyoung Han Hwang, Kee Houng Lee, Dae Yoel Lee

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Ghrelin is a novel gut-brain peptide that has somatotropic, orexigenic, and adipogenic effects. We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. No significant difference was found between Met72 carrier and non-carrier obese children with respect to BMI, total body fat, serum triglycerides, total cholesterol, or LDL-cholesterol levels. Our data suggest that the preproghrelin Leu72Met polymorphism is not associated with obesity in children.

Original language	English
Pages (from-to)	1083-1086
Number of pages	4
Journal	Journal of Pediatric Endocrinology and Metabolism
Volume	18
Issue number	11
DOIs	https://doi.org/10.1515/JPEM.2005.18.11.1083
Publication status	Published - 2005 Nov
Externally published	Yes

Keywords

Children
Ghrelin
Leu72Met polymorphism
Obesity

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Endocrinology, Diabetes and Metabolism
Endocrinology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1515/JPEM.2005.18.11.1083

Cite this

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title = "Preproghrelin Leu72Met polymorphism in obese Korean children",

abstract = "Ghrelin is a novel gut-brain peptide that has somatotropic, orexigenic, and adipogenic effects. We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. No significant difference was found between Met72 carrier and non-carrier obese children with respect to BMI, total body fat, serum triglycerides, total cholesterol, or LDL-cholesterol levels. Our data suggest that the preproghrelin Leu72Met polymorphism is not associated with obesity in children.",

keywords = "Children, Ghrelin, Leu72Met polymorphism, Obesity",

author = "Jo, {Dae Sun} and Kim, {Se Lim} and Kim, {Sun Young} and Hwang, {Pyoung Han} and Lee, {Kee Houng} and Lee, {Dae Yoel}",

note = "Funding Information: This study was supported by a Korea Foundation Grant (KRF-2004-E00111).",

year = "2005",

month = nov,

doi = "10.1515/JPEM.2005.18.11.1083",

language = "English",

volume = "18",

pages = "1083--1086",

journal = "Journal of Pediatric Endocrinology and Metabolism",

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T1 - Preproghrelin Leu72Met polymorphism in obese Korean children

AU - Jo, Dae Sun

AU - Kim, Se Lim

AU - Kim, Sun Young

AU - Hwang, Pyoung Han

AU - Lee, Kee Houng

AU - Lee, Dae Yoel

N1 - Funding Information: This study was supported by a Korea Foundation Grant (KRF-2004-E00111).

PY - 2005/11

Y1 - 2005/11

N2 - Ghrelin is a novel gut-brain peptide that has somatotropic, orexigenic, and adipogenic effects. We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. No significant difference was found between Met72 carrier and non-carrier obese children with respect to BMI, total body fat, serum triglycerides, total cholesterol, or LDL-cholesterol levels. Our data suggest that the preproghrelin Leu72Met polymorphism is not associated with obesity in children.

AB - Ghrelin is a novel gut-brain peptide that has somatotropic, orexigenic, and adipogenic effects. We examined the preproghrelin Leu72Met polymorphism in 222 obese Korean children to determine whether it is associated with obesity. The frequencies of the Leu72Met polymorphism were 29.3% in obese, 32.3% in overweight, and 32.5% in lean Korean children. No significant difference was found between Met72 carrier and non-carrier obese children with respect to BMI, total body fat, serum triglycerides, total cholesterol, or LDL-cholesterol levels. Our data suggest that the preproghrelin Leu72Met polymorphism is not associated with obesity in children.

KW - Children

KW - Ghrelin

KW - Leu72Met polymorphism

KW - Obesity

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IS - 11

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Preproghrelin Leu72Met polymorphism in obese Korean children

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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