TY - JOUR
T1 - Pressureless sintering and mechanical and biological properties of fluor-hydroxyapatite composites with zirconia
AU - Kim, Hae Won
AU - Kong, Young Min
AU - Koh, Young Hag
AU - Kim, Hyoun Ee
AU - Kim, Hyun Man
AU - Ko, Jea Seung
PY - 2003/12
Y1 - 2003/12
N2 - Fluor-hydroxyapatite (FHA) fabricated by a reaction between fluorapatite (FA) and hydroxyapatite (HA) was mixed with ZrO2 to produce FHA-ZrO2 composites. When the relative amount of FA to HA increased, the decomposition of the composite was decreased gradually because of the formation of thermally stable FHA solid solutions. With such suppression of decomposition, the FHA-ZrO2 composites retained fully densified bodies. As a result, significant enhancements in mechanical properties, such as hardness, flexural strength, and fracture toughness, were achieved as the relative amount of FA to HA increased. The highest values in strength and toughness were 220 MPa and 2.5 MPa·m1/2, respectively, with FHA-40 vol% ZrO2 composites. In vitro proliferation of osteoblast-like cells (MG63) on the composites showed behavior similar to that observed on pore HA and FHA. Alkaline phosphatase (ALP) activity of the growing cells (HOS) on the composites was slightly down-regulated compared with that on pure HA and FHA at prolonged periods.
AB - Fluor-hydroxyapatite (FHA) fabricated by a reaction between fluorapatite (FA) and hydroxyapatite (HA) was mixed with ZrO2 to produce FHA-ZrO2 composites. When the relative amount of FA to HA increased, the decomposition of the composite was decreased gradually because of the formation of thermally stable FHA solid solutions. With such suppression of decomposition, the FHA-ZrO2 composites retained fully densified bodies. As a result, significant enhancements in mechanical properties, such as hardness, flexural strength, and fracture toughness, were achieved as the relative amount of FA to HA increased. The highest values in strength and toughness were 220 MPa and 2.5 MPa·m1/2, respectively, with FHA-40 vol% ZrO2 composites. In vitro proliferation of osteoblast-like cells (MG63) on the composites showed behavior similar to that observed on pore HA and FHA. Alkaline phosphatase (ALP) activity of the growing cells (HOS) on the composites was slightly down-regulated compared with that on pure HA and FHA at prolonged periods.
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U2 - 10.1111/j.1151-2916.2003.tb03602.x
DO - 10.1111/j.1151-2916.2003.tb03602.x
M3 - Article
AN - SCOPUS:0346936234
SN - 0002-7820
VL - 86
SP - 2019
EP - 2026
JO - Journal of the American Ceramic Society
JF - Journal of the American Ceramic Society
IS - 12
ER -