Prestroke Antiplatelet Agents in First-Time Ischemic Stroke Are Related to Subtypes

Jin-Man Jung, Jaehyung Cha, Jungsoon Choi, Mi Yeon Eun, Woo Keun Seo, Kyungmi Oh, Kyung-Hee Cho, Sungwook Yu

Research output: Contribution to journalArticle

Abstract

Background: It is not well known whether prestroke antiplatelet agents (PAs) are associated with the subtypes of ischemic stroke. Methods: We screened patients in a hospital-based stroke registry. Patients who were admitted with a diagnosis of first-time ischemic stroke within 5 days of symptom onset were included. Ischemic stroke subtypes were classified in accordance with the Trial of ORG 10172 in Acute Stroke Treatment classification based on stroke mechanism: large-artery atherosclerosis (LA), cardioembolism (CE), small vessel occlusion (SVO), other determined (OC) or undetermined causes (UC). Multinomial logistic regression analyses were performed to evaluate the effect of PA on stroke subtypes before and after propensity score matching. Results: Among 3,025 patients, 748 (24.7%) were taking antiplatelet agents prior to stroke. After propensity score matching, 1,190 patients were ultimately included. The PA group was associated with strokes caused by SVO rather than LA in multinomial logistic regression of an unmatched dataset. However, multivariable analysis after propensity score matching demonstrated that PA use was associated with a higher probability of SVO and CE (OR 2.05, p < 0.001 and OR 1.62, p = 0.05, respectively) compared with LA. Conclusions: PAs were associated with specific index stroke subtypes.

Original languageEnglish
Pages (from-to)89-95
Number of pages7
JournalEuropean Neurology
Volume75
Issue number1-2
DOIs
Publication statusPublished - 2016 Mar 1

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Keywords

  • Ischemic stroke
  • Prestroke antiplatelet agents
  • Subtypes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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