Pretreatment serum level of 15-kDa granulysin might have a prognostic value in patients with diffuse large B cell lymphoma

Yong Park, Yoon Ji Choi, Se Jong Park, Se Ryeon Lee, Hwa Jung Sung, Kyong Hwa Park, Soek Jin Kim, Chul Won Choi, Kwang Yoon Jung, Byung Soo Kim

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Aim: Granulysin (cytolytic molecules of cytotoxic T lymphocytes and natural killer cells) is synthesized as cytosolic 9-kDa and secretary 15-kDa isoforms. We evaluated the prognostic significance of the pretreatment serum level of 15-kDa granulysin in patients with diffuse large B cell lymphoma (DLBCL). Patients and Methods: A retrospective analysis was conducted on 88 DLBCL patients treated homogeneously with standard chemotherapy. The granulysin level was quantified in pretreatment samples. Results: The granulysin level in DLBCL patients was significantly lower than that in healthy controls (522 ± 496 vs. 1,945 ± 1,696 pg/ml; p < 0.0001), and the level in patients who experienced recurrence within 3 years was significantly lower than that of patients without recurrence (305 ± 337 vs. 720 ± 607 pg/ml; p = 0.001). Patients with granulysin levels higher than the median level showed significantly longer progression-free and overall survival according to univariate analysis (p = 0.031 and p = 0.014, respectively). In multivariate analysis, the granulysin level was an independently significant prognostic factor of overall survival (p = 0.018; hazard ratio, 0.521; 95% confidence interval, 0.188-0.841). Conclusions: Pretreatment serum level of 15-kDa granulysin may be a valuable prognostic marker in DLBCL patients treated with standard chemotherapy.

Original languageEnglish
Pages (from-to)79-86
Number of pages8
JournalActa Haematologica
Volume126
Issue number2
DOIs
Publication statusPublished - 2011 Aug

Keywords

  • Chemotherapy
  • Diffuse large B cell lymphoma
  • Granulysin

ASJC Scopus subject areas

  • Hematology

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