Prevalence and clinical characteristics of major depressive disorder (MDD) without depressed mood in Koreans with MDD: Results from the CRESCEND study

Seon Cheol Park, Hong Seok Oh, Jae Min Kim, Tae Youn Jun, Min-Soo Lee, Jung Bum Kim, Hyeon Woo Yim, Yong Chon Park

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We examined the prevalence and clinical characteristics of patients with major depressive disorder (MDD) without depressed mood, using data from the Clinical Research Center for Depression (CRESCEND) study in South Korea. Methods: Using analysis of covariance for continuous variables and binary logistic regression analysis for discrete variables, the clinical characteristics of MDD patients with and without depressed mood were compared after controlling for the potential effects of gender. To represent the extent of group differences, we computed Cohen’s d statistics. Results: Of 1009 MDD patients, only 2.2% were without depressed mood. Compared with those with depressed mood, these patients were characterized by a significantly lower rate of current suicidal ideation (adjust odds ratio = 5.258, p = .003; d = 0.193), fewer depressive symptom profiles (F = 8.731, p = .003; d = −0.543) and lower severity scores for overall depression (F = 16.027, p < .0001; d = −0.853), core depressive symptoms (F = 14.233, p < .0001; d = −0.810), insomnia (F = 6.967, p = .008; d = −0.579), anxiety (F = 14.235, p < .0001; d = −0.810), and suicidal ideation (F = 9.034, p = .003; d = 0.531), as well as a higher level of social functioning (F = 6.862, p = .009; d = 0.531). Conclusions: MDD without depressed mood is associated with a lower illness burden than MDD with depressed mood, and may have the distinctive clinical characteristics of MDD.

Original languageEnglish
Pages (from-to)435-438
Number of pages4
JournalPsychiatry and Clinical Psychopharmacology
Volume27
Issue number4
DOIs
Publication statusPublished - 2017 Jan 1

Keywords

  • Anxiety
  • Depressed mood
  • Illness burden
  • Major depressive disorder
  • Suicidal ideation

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health

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