Prevalence and clinical significance of biliary intraepithelial neoplasia (BilIN) in cholangiocarcinoma

Kyung Chul Yoon, Young-Dong Yu, Woo Hyung Kang, Hye Sung Jo, Dong-Sik Kim, Joo Young Kim

Research output: Contribution to journalArticle

Abstract

Biliary intraepithelial neoplasia (BilIN) is the most common noninvasive precursor lesion which progresses to cholangiocarcinoma (CC) and is often found synchronously adjacent to the tumor or at the surgical resection margin. The aim of this study was to elucidate the prevalence and prognostic effect of BilIN on survival after resection for CC. We retrospectively analyzed the database of patients with CC who underwent surgery performed at our institution from 2010 to 2017. There were 142 patients who underwent surgery for CC. BilIN was detected in 42 patients (29.5%). On univariate analysis, extrahepatic CC (ExtraH CC) patients with BilIN lesions significantly showed better disease-free survival (P 5 0.05). Also, although not statistically significant, ExtraH CC patients with BilIN lesions revealed better overall survival (OS) (P 5 0.09). On multivariate analysis, presence of BilIN lesion, irrespective of location, was significantly associated with better disease-free survival (HR 5 2.059, 95% confidence interval (CI): 1.057-4.432, P 5 0.041) and OS (HR 5 1.831, 95% CI: 1.149-3.534, P 5 0.044) in ExtraH CC patients. The presence of BilIN lesions was not uncommon in CC patients and was significantly associated with better diseasefree survival and OS in ExtraH CC patients. However, larger studies with longer follow-up are needed to accurately determine its clinical significance.

Original languageEnglish
Pages (from-to)511-517
Number of pages7
JournalAmerican Surgeon
Volume85
Issue number5
Publication statusPublished - 2019 May 1

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Cholangiocarcinoma
Neoplasms
Survival
Disease-Free Survival
Confidence Intervals
Multivariate Analysis
Databases

ASJC Scopus subject areas

  • Surgery

Cite this

Prevalence and clinical significance of biliary intraepithelial neoplasia (BilIN) in cholangiocarcinoma. / Yoon, Kyung Chul; Yu, Young-Dong; Kang, Woo Hyung; Jo, Hye Sung; Kim, Dong-Sik; Kim, Joo Young.

In: American Surgeon, Vol. 85, No. 5, 01.05.2019, p. 511-517.

Research output: Contribution to journalArticle

Yoon, Kyung Chul ; Yu, Young-Dong ; Kang, Woo Hyung ; Jo, Hye Sung ; Kim, Dong-Sik ; Kim, Joo Young. / Prevalence and clinical significance of biliary intraepithelial neoplasia (BilIN) in cholangiocarcinoma. In: American Surgeon. 2019 ; Vol. 85, No. 5. pp. 511-517.
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