Prevalence and determinants of diabetic nephropathy in Korea: Korea National Health and Nutrition examination survey

Jae Hee Ahn, Ji Hee Yu, Seung Hyun Ko, Hyuk Sang Kwon, Dae Jung Kim, Jae Hyeon Kim, Chul Sik Kim, Kee Ho Song, Jong Chul Won, Soo Lim, Sung Hee Choi, Kyungdo Han, Bong Yun Cha, Nan Hee Kim

Research output: Contribution to journalArticle

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Abstract

Background: Diabetic nephropathy is a leading cause of end stage renal disease and is associated with an increased risk of cardiovascular mortality. It manifests as albuminuria or impaired glomerular filtration rate (GFR), and the prevalence of diabetic nephropathy varies with ethnicity. The prevalence of diabetic nephropathy and its determinants in Korean adults have not previously been studied at the national level. This cross-sectional study was undertaken to ascertain the prevalence and determinants of albuminuria and chronic kidney disease (CKD) in Korean patients with diabetes. Methods: The Korea National Health and Nutrition Examination Survey (KNHANES) V, conducted in 2011, was used to define albuminuria (n=4,652), and the dataset of KNHANES IV-V (2008-2011) was used to define CKD (n=21,521). Selected samples were weighted to represent the entire civilian population in Korea. Albuminuria was defined as a spot urine albumin/creatinine ratio >30 mg/g. CKD was defined as a GFR <60 mL/min/1.73 m2. Results: Among subjects with diabetes, 26.7% had albuminuria, and 8.6% had CKD. Diabetes was associated with an approximate 2.5-fold increased risk of albuminuria, with virtually no difference between new-onset and previously diagnosed diabetes. Only systolic blood pressure was significantly associated with albuminuria, and old age, high serum triglyceride levels, and previous cardiovascular disease (CVD) were related with CKD in subjects with diabetes. Conclusion: Korean subjects with diabetes had a higher prevalence of albuminuria and CKD than those without diabetes. Blood pressure was associated with albuminuria, and age, triglyceride level, and previous CVD were independent determinants of CKD in subjects with diabetes.

Original languageEnglish
Pages (from-to)109-119
Number of pages11
JournalDiabetes and Metabolism Journal
Volume38
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

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Albuminuria
Nutrition Surveys
Diabetic Nephropathies
Korea
Chronic Renal Insufficiency
Blood Pressure
Glomerular Filtration Rate
Triglycerides
Cardiovascular Diseases
Chronic Kidney Failure
Albumins
Creatinine
Cross-Sectional Studies
Urine
Mortality

Keywords

  • Albuminuria
  • Chronic renal disease
  • Diabetes mellitus
  • Diabetic nephropathy
  • Korea

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Prevalence and determinants of diabetic nephropathy in Korea : Korea National Health and Nutrition examination survey. / Ahn, Jae Hee; Yu, Ji Hee; Ko, Seung Hyun; Kwon, Hyuk Sang; Kim, Dae Jung; Kim, Jae Hyeon; Kim, Chul Sik; Song, Kee Ho; Won, Jong Chul; Lim, Soo; Choi, Sung Hee; Han, Kyungdo; Cha, Bong Yun; Kim, Nan Hee.

In: Diabetes and Metabolism Journal, Vol. 38, No. 2, 01.01.2014, p. 109-119.

Research output: Contribution to journalArticle

Ahn, JH, Yu, JH, Ko, SH, Kwon, HS, Kim, DJ, Kim, JH, Kim, CS, Song, KH, Won, JC, Lim, S, Choi, SH, Han, K, Cha, BY & Kim, NH 2014, 'Prevalence and determinants of diabetic nephropathy in Korea: Korea National Health and Nutrition examination survey', Diabetes and Metabolism Journal, vol. 38, no. 2, pp. 109-119. https://doi.org/10.4093/dmj.2014.38.2.109
Ahn, Jae Hee ; Yu, Ji Hee ; Ko, Seung Hyun ; Kwon, Hyuk Sang ; Kim, Dae Jung ; Kim, Jae Hyeon ; Kim, Chul Sik ; Song, Kee Ho ; Won, Jong Chul ; Lim, Soo ; Choi, Sung Hee ; Han, Kyungdo ; Cha, Bong Yun ; Kim, Nan Hee. / Prevalence and determinants of diabetic nephropathy in Korea : Korea National Health and Nutrition examination survey. In: Diabetes and Metabolism Journal. 2014 ; Vol. 38, No. 2. pp. 109-119.
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abstract = "Background: Diabetic nephropathy is a leading cause of end stage renal disease and is associated with an increased risk of cardiovascular mortality. It manifests as albuminuria or impaired glomerular filtration rate (GFR), and the prevalence of diabetic nephropathy varies with ethnicity. The prevalence of diabetic nephropathy and its determinants in Korean adults have not previously been studied at the national level. This cross-sectional study was undertaken to ascertain the prevalence and determinants of albuminuria and chronic kidney disease (CKD) in Korean patients with diabetes. Methods: The Korea National Health and Nutrition Examination Survey (KNHANES) V, conducted in 2011, was used to define albuminuria (n=4,652), and the dataset of KNHANES IV-V (2008-2011) was used to define CKD (n=21,521). Selected samples were weighted to represent the entire civilian population in Korea. Albuminuria was defined as a spot urine albumin/creatinine ratio >30 mg/g. CKD was defined as a GFR <60 mL/min/1.73 m2. Results: Among subjects with diabetes, 26.7{\%} had albuminuria, and 8.6{\%} had CKD. Diabetes was associated with an approximate 2.5-fold increased risk of albuminuria, with virtually no difference between new-onset and previously diagnosed diabetes. Only systolic blood pressure was significantly associated with albuminuria, and old age, high serum triglyceride levels, and previous cardiovascular disease (CVD) were related with CKD in subjects with diabetes. Conclusion: Korean subjects with diabetes had a higher prevalence of albuminuria and CKD than those without diabetes. Blood pressure was associated with albuminuria, and age, triglyceride level, and previous CVD were independent determinants of CKD in subjects with diabetes.",
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T1 - Prevalence and determinants of diabetic nephropathy in Korea

T2 - Korea National Health and Nutrition examination survey

AU - Ahn, Jae Hee

AU - Yu, Ji Hee

AU - Ko, Seung Hyun

AU - Kwon, Hyuk Sang

AU - Kim, Dae Jung

AU - Kim, Jae Hyeon

AU - Kim, Chul Sik

AU - Song, Kee Ho

AU - Won, Jong Chul

AU - Lim, Soo

AU - Choi, Sung Hee

AU - Han, Kyungdo

AU - Cha, Bong Yun

AU - Kim, Nan Hee

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Diabetic nephropathy is a leading cause of end stage renal disease and is associated with an increased risk of cardiovascular mortality. It manifests as albuminuria or impaired glomerular filtration rate (GFR), and the prevalence of diabetic nephropathy varies with ethnicity. The prevalence of diabetic nephropathy and its determinants in Korean adults have not previously been studied at the national level. This cross-sectional study was undertaken to ascertain the prevalence and determinants of albuminuria and chronic kidney disease (CKD) in Korean patients with diabetes. Methods: The Korea National Health and Nutrition Examination Survey (KNHANES) V, conducted in 2011, was used to define albuminuria (n=4,652), and the dataset of KNHANES IV-V (2008-2011) was used to define CKD (n=21,521). Selected samples were weighted to represent the entire civilian population in Korea. Albuminuria was defined as a spot urine albumin/creatinine ratio >30 mg/g. CKD was defined as a GFR <60 mL/min/1.73 m2. Results: Among subjects with diabetes, 26.7% had albuminuria, and 8.6% had CKD. Diabetes was associated with an approximate 2.5-fold increased risk of albuminuria, with virtually no difference between new-onset and previously diagnosed diabetes. Only systolic blood pressure was significantly associated with albuminuria, and old age, high serum triglyceride levels, and previous cardiovascular disease (CVD) were related with CKD in subjects with diabetes. Conclusion: Korean subjects with diabetes had a higher prevalence of albuminuria and CKD than those without diabetes. Blood pressure was associated with albuminuria, and age, triglyceride level, and previous CVD were independent determinants of CKD in subjects with diabetes.

AB - Background: Diabetic nephropathy is a leading cause of end stage renal disease and is associated with an increased risk of cardiovascular mortality. It manifests as albuminuria or impaired glomerular filtration rate (GFR), and the prevalence of diabetic nephropathy varies with ethnicity. The prevalence of diabetic nephropathy and its determinants in Korean adults have not previously been studied at the national level. This cross-sectional study was undertaken to ascertain the prevalence and determinants of albuminuria and chronic kidney disease (CKD) in Korean patients with diabetes. Methods: The Korea National Health and Nutrition Examination Survey (KNHANES) V, conducted in 2011, was used to define albuminuria (n=4,652), and the dataset of KNHANES IV-V (2008-2011) was used to define CKD (n=21,521). Selected samples were weighted to represent the entire civilian population in Korea. Albuminuria was defined as a spot urine albumin/creatinine ratio >30 mg/g. CKD was defined as a GFR <60 mL/min/1.73 m2. Results: Among subjects with diabetes, 26.7% had albuminuria, and 8.6% had CKD. Diabetes was associated with an approximate 2.5-fold increased risk of albuminuria, with virtually no difference between new-onset and previously diagnosed diabetes. Only systolic blood pressure was significantly associated with albuminuria, and old age, high serum triglyceride levels, and previous cardiovascular disease (CVD) were related with CKD in subjects with diabetes. Conclusion: Korean subjects with diabetes had a higher prevalence of albuminuria and CKD than those without diabetes. Blood pressure was associated with albuminuria, and age, triglyceride level, and previous CVD were independent determinants of CKD in subjects with diabetes.

KW - Albuminuria

KW - Chronic renal disease

KW - Diabetes mellitus

KW - Diabetic nephropathy

KW - Korea

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