Prevalence and genotype distribution of cervical human papillomavirus DNA in Korean women

A multicenter study

Sung Ran Hong, In Sun KiM, Dong Won Kim, Mi Jin Kim, Aeree Kim, Young Ok Kim, Hye Sun Kim, Seo Hee Rha, Gyeong Sin Park, Yong Koo Park, Yong Wook Park, Ho Sung Park, Kwang Sun Suh, Jin Hee Sohn, Mi Kyung Shin, Hoon Kyu Oh, Ki Jung Yun, Hye Kyoung Yoon, Shi Nae Lee, Ah Won Lee & 4 others Hyo Jin Lee, Hyun Yee Cho, Chan Choi, Woon Won Jung

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: DNA prevalence and type distribution of human papillomavirus (HPV) varies geographically. We investigated HPV prevalence and type distribution in Korean women using the MyHPV DNA chip testing. Methods: A total of 2,368 women from five regions of the country underwent Pap smear examination and MyHPV chip testing. Results: Overall HPV positivity was 15.8% and 78.4% in women with normal and abnormal cytology, respectively. Highrisk HPV infection was strongly correlated with cytological atypia. In women with abnormal cytology, the five most common HPV types were 16, 58, 18, 52, and 56/53, and HPV16 was significantly the most common type in most geographical regions. After HPV16, HPV58, and 52 were the next most frequently detected types. Women with normal cytology, in contrast, showed heterogeneity in HPV type distribution. High-grade intraepithelial lesions infected with HPV16, 18, 31 or 45 are more likely to progress to carcinoma. Conclusions: The HPV chip test can provide useful data regarding HPV positivity and type. The most common HPV type in Korean women with abnormal cytology is HPV16, with HPV58 and 52 being frequently present. Our data may have important implications for vaccination programs and the development of cervical screening.

Original languageEnglish
Pages (from-to)342-350
Number of pages9
JournalKorean Journal of Pathology
Volume43
Issue number4
DOIs
Publication statusPublished - 2009 Aug 1

Fingerprint

Multicenter Studies
Genotype
DNA
Cell Biology
Papanicolaou Test
Program Development
Papillomavirus Infections
Human papillomavirus 16
Oligonucleotide Array Sequence Analysis
Vaccination
Carcinoma

Keywords

  • DNA chips
  • Human papillomavirus
  • Papanicolaou test
  • South Korea
  • Uterine cervix

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Prevalence and genotype distribution of cervical human papillomavirus DNA in Korean women : A multicenter study. / Hong, Sung Ran; KiM, In Sun; Kim, Dong Won; Kim, Mi Jin; Kim, Aeree; Kim, Young Ok; Kim, Hye Sun; Rha, Seo Hee; Park, Gyeong Sin; Park, Yong Koo; Park, Yong Wook; Park, Ho Sung; Suh, Kwang Sun; Sohn, Jin Hee; Shin, Mi Kyung; Oh, Hoon Kyu; Yun, Ki Jung; Yoon, Hye Kyoung; Lee, Shi Nae; Lee, Ah Won; Lee, Hyo Jin; Cho, Hyun Yee; Choi, Chan; Jung, Woon Won.

In: Korean Journal of Pathology, Vol. 43, No. 4, 01.08.2009, p. 342-350.

Research output: Contribution to journalArticle

Hong, SR, KiM, IS, Kim, DW, Kim, MJ, Kim, A, Kim, YO, Kim, HS, Rha, SH, Park, GS, Park, YK, Park, YW, Park, HS, Suh, KS, Sohn, JH, Shin, MK, Oh, HK, Yun, KJ, Yoon, HK, Lee, SN, Lee, AW, Lee, HJ, Cho, HY, Choi, C & Jung, WW 2009, 'Prevalence and genotype distribution of cervical human papillomavirus DNA in Korean women: A multicenter study', Korean Journal of Pathology, vol. 43, no. 4, pp. 342-350. https://doi.org/10.4132/KoreanJPathol.2009.43.4.342
Hong, Sung Ran ; KiM, In Sun ; Kim, Dong Won ; Kim, Mi Jin ; Kim, Aeree ; Kim, Young Ok ; Kim, Hye Sun ; Rha, Seo Hee ; Park, Gyeong Sin ; Park, Yong Koo ; Park, Yong Wook ; Park, Ho Sung ; Suh, Kwang Sun ; Sohn, Jin Hee ; Shin, Mi Kyung ; Oh, Hoon Kyu ; Yun, Ki Jung ; Yoon, Hye Kyoung ; Lee, Shi Nae ; Lee, Ah Won ; Lee, Hyo Jin ; Cho, Hyun Yee ; Choi, Chan ; Jung, Woon Won. / Prevalence and genotype distribution of cervical human papillomavirus DNA in Korean women : A multicenter study. In: Korean Journal of Pathology. 2009 ; Vol. 43, No. 4. pp. 342-350.
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abstract = "Background: DNA prevalence and type distribution of human papillomavirus (HPV) varies geographically. We investigated HPV prevalence and type distribution in Korean women using the MyHPV DNA chip testing. Methods: A total of 2,368 women from five regions of the country underwent Pap smear examination and MyHPV chip testing. Results: Overall HPV positivity was 15.8{\%} and 78.4{\%} in women with normal and abnormal cytology, respectively. Highrisk HPV infection was strongly correlated with cytological atypia. In women with abnormal cytology, the five most common HPV types were 16, 58, 18, 52, and 56/53, and HPV16 was significantly the most common type in most geographical regions. After HPV16, HPV58, and 52 were the next most frequently detected types. Women with normal cytology, in contrast, showed heterogeneity in HPV type distribution. High-grade intraepithelial lesions infected with HPV16, 18, 31 or 45 are more likely to progress to carcinoma. Conclusions: The HPV chip test can provide useful data regarding HPV positivity and type. The most common HPV type in Korean women with abnormal cytology is HPV16, with HPV58 and 52 being frequently present. Our data may have important implications for vaccination programs and the development of cervical screening.",
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AU - Kim, Aeree

AU - Kim, Young Ok

AU - Kim, Hye Sun

AU - Rha, Seo Hee

AU - Park, Gyeong Sin

AU - Park, Yong Koo

AU - Park, Yong Wook

AU - Park, Ho Sung

AU - Suh, Kwang Sun

AU - Sohn, Jin Hee

AU - Shin, Mi Kyung

AU - Oh, Hoon Kyu

AU - Yun, Ki Jung

AU - Yoon, Hye Kyoung

AU - Lee, Shi Nae

AU - Lee, Ah Won

AU - Lee, Hyo Jin

AU - Cho, Hyun Yee

AU - Choi, Chan

AU - Jung, Woon Won

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N2 - Background: DNA prevalence and type distribution of human papillomavirus (HPV) varies geographically. We investigated HPV prevalence and type distribution in Korean women using the MyHPV DNA chip testing. Methods: A total of 2,368 women from five regions of the country underwent Pap smear examination and MyHPV chip testing. Results: Overall HPV positivity was 15.8% and 78.4% in women with normal and abnormal cytology, respectively. Highrisk HPV infection was strongly correlated with cytological atypia. In women with abnormal cytology, the five most common HPV types were 16, 58, 18, 52, and 56/53, and HPV16 was significantly the most common type in most geographical regions. After HPV16, HPV58, and 52 were the next most frequently detected types. Women with normal cytology, in contrast, showed heterogeneity in HPV type distribution. High-grade intraepithelial lesions infected with HPV16, 18, 31 or 45 are more likely to progress to carcinoma. Conclusions: The HPV chip test can provide useful data regarding HPV positivity and type. The most common HPV type in Korean women with abnormal cytology is HPV16, with HPV58 and 52 being frequently present. Our data may have important implications for vaccination programs and the development of cervical screening.

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