Prevalence and genotype distribution of cervical human papillomavirus DNA in Korean women: A multicenter study

Sung Ran Hong, In Sun KiM, Dong Won Kim, Mi Jin Kim, Ae Ree Kim, Young Ok Kim, Hye Sun Kim, Seo Hee Rha, Gyeong Sin Park, Yong Koo Park, Yong Wook Park, Ho Sung Park, Kwang Sun Suh, Jin Hee Sohn, Mi Kyung Shin, Hoon Kyu Oh, Ki Jung Yun, Hye Kyoung Yoon, Shi Nae Lee, Ah Won LeeHyo Jin Lee, Hyun Yee Cho, Chan Choi, Woon Won Jung

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: DNA prevalence and type distribution of human papillomavirus (HPV) varies geographically. We investigated HPV prevalence and type distribution in Korean women using the MyHPV DNA chip testing. Methods: A total of 2,368 women from five regions of the country underwent Pap smear examination and MyHPV chip testing. Results: Overall HPV positivity was 15.8% and 78.4% in women with normal and abnormal cytology, respectively. Highrisk HPV infection was strongly correlated with cytological atypia. In women with abnormal cytology, the five most common HPV types were 16, 58, 18, 52, and 56/53, and HPV16 was significantly the most common type in most geographical regions. After HPV16, HPV58, and 52 were the next most frequently detected types. Women with normal cytology, in contrast, showed heterogeneity in HPV type distribution. High-grade intraepithelial lesions infected with HPV16, 18, 31 or 45 are more likely to progress to carcinoma. Conclusions: The HPV chip test can provide useful data regarding HPV positivity and type. The most common HPV type in Korean women with abnormal cytology is HPV16, with HPV58 and 52 being frequently present. Our data may have important implications for vaccination programs and the development of cervical screening.

Original languageEnglish
Pages (from-to)342-350
Number of pages9
JournalKorean Journal of Pathology
Volume43
Issue number4
DOIs
Publication statusPublished - 2009 Aug

Keywords

  • DNA chips
  • Human papillomavirus
  • Papanicolaou test
  • South Korea
  • Uterine cervix

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Hong, S. R., KiM, I. S., Kim, D. W., Kim, M. J., Kim, A. R., Kim, Y. O., Kim, H. S., Rha, S. H., Park, G. S., Park, Y. K., Park, Y. W., Park, H. S., Suh, K. S., Sohn, J. H., Shin, M. K., Oh, H. K., Yun, K. J., Yoon, H. K., Lee, S. N., ... Jung, W. W. (2009). Prevalence and genotype distribution of cervical human papillomavirus DNA in Korean women: A multicenter study. Korean Journal of Pathology, 43(4), 342-350. https://doi.org/10.4132/KoreanJPathol.2009.43.4.342