Prevalence and treatment pattern of Parkinson's disease dementia in Korea

Yoon Sang Oh, Joong Seok Kim, In Seok Park, Yong Soo Shim, In Uk Song, Jeong Wook Park, Phil Hyu Lee, Chul Hyung Lyoo, Tae Beom Ahn, Hyo Il Ma, Yong Duk Kim, Seong Beom Koh, Seung Jae Lee, Kwang Soo Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim: The aim of the present study was to investigate the point prevalence of dementia and mild cognitive impairment (MCI) in patients with Parkinson's disease (PD). Methods: A total of 1200 patients with PD from 12 hospitals were included in the study. All patients were grouped into normal cognition, MCI and dementia subgroups. General cognitive status and dementia severity were assessed by the Korean version of the Mini-Mental State Examination, Clinical Dementia Rating and Global Deterioration Scale, and parkinsonian motor status was assessed by the Hoehn and Yahr staging score. Associated sleep behaviors and other medical conditions were checked. Prescribing patterns of antidementia medications were analyzed. Results: Cognitive impairment was frequent in patients with PD; MCI was found in 38.9% of patients, whereas dementia was in 38.3% of patients. The prevalence of cognitive impairment increased with increasing age and longer disease duration, and the symptoms of postural instability and symptoms mimicking rapid eye movement sleep behavior disorder were associated with cognitive impairment. Many dementia patients (95.2%) and 23.6% of MCI patients were treated with antidementia drugs, with rivastigmine the most frequently used. Conclusion: The point prevalence of cognitive impairment in patients with PD was 77.2%. Cognitive impairment was associated with age, disease duration and specific parkinsonian motor/non-motor symptoms. Over 90% of the patients with dementia were treated with antidementia medication, and rivastigmine was the most frequently used for the management of dementia.

Original languageEnglish
Pages (from-to)230-236
Number of pages7
JournalGeriatrics and Gerontology International
Volume16
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

Fingerprint

Korea
dementia
Parkinson Disease
Dementia
Disease
Rivastigmine
Therapeutics
sleep
medication
behavior disorder
REM Sleep Behavior Disorder
staging
Cognitive Dysfunction
cognition
rating
Cognition
drug
Sleep
examination
management

Keywords

  • Cognitive impairment
  • Dementia
  • Parkinson's disease
  • Prevalence
  • Treatment

ASJC Scopus subject areas

  • Health(social science)
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Oh, Y. S., Kim, J. S., Park, I. S., Shim, Y. S., Song, I. U., Park, J. W., ... Lee, K. S. (2016). Prevalence and treatment pattern of Parkinson's disease dementia in Korea. Geriatrics and Gerontology International, 16(2), 230-236. https://doi.org/10.1111/ggi.12457

Prevalence and treatment pattern of Parkinson's disease dementia in Korea. / Oh, Yoon Sang; Kim, Joong Seok; Park, In Seok; Shim, Yong Soo; Song, In Uk; Park, Jeong Wook; Lee, Phil Hyu; Lyoo, Chul Hyung; Ahn, Tae Beom; Ma, Hyo Il; Kim, Yong Duk; Koh, Seong Beom; Lee, Seung Jae; Lee, Kwang Soo.

In: Geriatrics and Gerontology International, Vol. 16, No. 2, 01.02.2016, p. 230-236.

Research output: Contribution to journalArticle

Oh, YS, Kim, JS, Park, IS, Shim, YS, Song, IU, Park, JW, Lee, PH, Lyoo, CH, Ahn, TB, Ma, HI, Kim, YD, Koh, SB, Lee, SJ & Lee, KS 2016, 'Prevalence and treatment pattern of Parkinson's disease dementia in Korea', Geriatrics and Gerontology International, vol. 16, no. 2, pp. 230-236. https://doi.org/10.1111/ggi.12457
Oh, Yoon Sang ; Kim, Joong Seok ; Park, In Seok ; Shim, Yong Soo ; Song, In Uk ; Park, Jeong Wook ; Lee, Phil Hyu ; Lyoo, Chul Hyung ; Ahn, Tae Beom ; Ma, Hyo Il ; Kim, Yong Duk ; Koh, Seong Beom ; Lee, Seung Jae ; Lee, Kwang Soo. / Prevalence and treatment pattern of Parkinson's disease dementia in Korea. In: Geriatrics and Gerontology International. 2016 ; Vol. 16, No. 2. pp. 230-236.
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abstract = "Aim: The aim of the present study was to investigate the point prevalence of dementia and mild cognitive impairment (MCI) in patients with Parkinson's disease (PD). Methods: A total of 1200 patients with PD from 12 hospitals were included in the study. All patients were grouped into normal cognition, MCI and dementia subgroups. General cognitive status and dementia severity were assessed by the Korean version of the Mini-Mental State Examination, Clinical Dementia Rating and Global Deterioration Scale, and parkinsonian motor status was assessed by the Hoehn and Yahr staging score. Associated sleep behaviors and other medical conditions were checked. Prescribing patterns of antidementia medications were analyzed. Results: Cognitive impairment was frequent in patients with PD; MCI was found in 38.9{\%} of patients, whereas dementia was in 38.3{\%} of patients. The prevalence of cognitive impairment increased with increasing age and longer disease duration, and the symptoms of postural instability and symptoms mimicking rapid eye movement sleep behavior disorder were associated with cognitive impairment. Many dementia patients (95.2{\%}) and 23.6{\%} of MCI patients were treated with antidementia drugs, with rivastigmine the most frequently used. Conclusion: The point prevalence of cognitive impairment in patients with PD was 77.2{\%}. Cognitive impairment was associated with age, disease duration and specific parkinsonian motor/non-motor symptoms. Over 90{\%} of the patients with dementia were treated with antidementia medication, and rivastigmine was the most frequently used for the management of dementia.",
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AU - Park, Jeong Wook

AU - Lee, Phil Hyu

AU - Lyoo, Chul Hyung

AU - Ahn, Tae Beom

AU - Ma, Hyo Il

AU - Kim, Yong Duk

AU - Koh, Seong Beom

AU - Lee, Seung Jae

AU - Lee, Kwang Soo

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N2 - Aim: The aim of the present study was to investigate the point prevalence of dementia and mild cognitive impairment (MCI) in patients with Parkinson's disease (PD). Methods: A total of 1200 patients with PD from 12 hospitals were included in the study. All patients were grouped into normal cognition, MCI and dementia subgroups. General cognitive status and dementia severity were assessed by the Korean version of the Mini-Mental State Examination, Clinical Dementia Rating and Global Deterioration Scale, and parkinsonian motor status was assessed by the Hoehn and Yahr staging score. Associated sleep behaviors and other medical conditions were checked. Prescribing patterns of antidementia medications were analyzed. Results: Cognitive impairment was frequent in patients with PD; MCI was found in 38.9% of patients, whereas dementia was in 38.3% of patients. The prevalence of cognitive impairment increased with increasing age and longer disease duration, and the symptoms of postural instability and symptoms mimicking rapid eye movement sleep behavior disorder were associated with cognitive impairment. Many dementia patients (95.2%) and 23.6% of MCI patients were treated with antidementia drugs, with rivastigmine the most frequently used. Conclusion: The point prevalence of cognitive impairment in patients with PD was 77.2%. Cognitive impairment was associated with age, disease duration and specific parkinsonian motor/non-motor symptoms. Over 90% of the patients with dementia were treated with antidementia medication, and rivastigmine was the most frequently used for the management of dementia.

AB - Aim: The aim of the present study was to investigate the point prevalence of dementia and mild cognitive impairment (MCI) in patients with Parkinson's disease (PD). Methods: A total of 1200 patients with PD from 12 hospitals were included in the study. All patients were grouped into normal cognition, MCI and dementia subgroups. General cognitive status and dementia severity were assessed by the Korean version of the Mini-Mental State Examination, Clinical Dementia Rating and Global Deterioration Scale, and parkinsonian motor status was assessed by the Hoehn and Yahr staging score. Associated sleep behaviors and other medical conditions were checked. Prescribing patterns of antidementia medications were analyzed. Results: Cognitive impairment was frequent in patients with PD; MCI was found in 38.9% of patients, whereas dementia was in 38.3% of patients. The prevalence of cognitive impairment increased with increasing age and longer disease duration, and the symptoms of postural instability and symptoms mimicking rapid eye movement sleep behavior disorder were associated with cognitive impairment. Many dementia patients (95.2%) and 23.6% of MCI patients were treated with antidementia drugs, with rivastigmine the most frequently used. Conclusion: The point prevalence of cognitive impairment in patients with PD was 77.2%. Cognitive impairment was associated with age, disease duration and specific parkinsonian motor/non-motor symptoms. Over 90% of the patients with dementia were treated with antidementia medication, and rivastigmine was the most frequently used for the management of dementia.

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