Prevalence of C-C chemokine receptor type 5 tropism among human immunodeficiency virus 1–infected patients in South Korea

Je Eun Song, Mi Young Ahn, Woo Joo Kim, Shin Woo Kim, Jin Soo Lee, Nam Su Ku, Joon Hyung Kim, Ki Hyon Kim, Heawon Ann, Jun Yong Choi

Research output: Contribution to journalArticle

Abstract

Objective: The discovery of two main coreceptors for human immunodeficiency virus (HIV), C-C chemokine receptor type 5 (CCR5), and C-X-C chemokine receptor type 4 has led to a better understanding of the interaction between HIV envelope and host cells, and development of new therapeutic approaches. The purpose of this study was to estimate the prevalence of CCR5 tropism among HIV-1–infected Koreans and identify the predictors for CCR5 tropism. Methods: We enrolled 250 HIV-1–infected subjects from four medical centers of three different cities in South Korea between April 2013 and May 2014. Genotypic assay for identifying coreceptor tropism of HIV-1 was performed with HIV RNA or HIV DNA. Nested polymerase chain reaction and population-based sequencing for the V3 region (HXB2 position 6225-7758) of the envelope were performed with HIV RNA or proviral DNA. Proviral DNA was used if the viral load of the subject was below 2000 copies/mL. Genotypic tropism was determined by a web-based bioinformatics tool (http://coreceptor.bioinf.mpi-inf.mpg.de/). Results: Among 250 individuals enrolled, only 143 subjects could be analyzed for genotypic tropism assay with HIV RNA or proviral DNA. The prevalence of CCR5 tropism was 69.2% (N = 99). We could not identify any significant clinical or epidemiological predictors for CCR5 tropism among enrolled subjects. Conclusions: The prevalence of CCR5 tropism in HIV-1–infected Korean individuals was 69.2%. Since we cannot predict coreceptor tropism by clinical factors, tropism assay should be performed before treatment with the CCR5 antagonist.

Original languageEnglish
Pages (from-to)1720-1723
Number of pages4
JournalJournal of Medical Virology
Volume90
Issue number11
DOIs
Publication statusPublished - 2018 Nov 1

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Keywords

  • antiretrovirus drug
  • human immunodeficiency virus
  • receptor

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Song, J. E., Ahn, M. Y., Kim, W. J., Kim, S. W., Lee, J. S., Ku, N. S., Kim, J. H., Kim, K. H., Ann, H., & Choi, J. Y. (2018). Prevalence of C-C chemokine receptor type 5 tropism among human immunodeficiency virus 1–infected patients in South Korea. Journal of Medical Virology, 90(11), 1720-1723. https://doi.org/10.1002/jmv.25254