Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey

Ho Gak Kim, Jimin Han, Myung Hwan Kim, Kyu Hyun Cho, Im Hee Shin, Gwang Ha Kim, Jae Seon Kim, Jin Bong Kim, Tae Nyeun Kim, Tae Hyeon Kim, Tae Hyo Kim, Jae Woo Kim, Ji Kon Ryu, Young Soo Moon, Jong Ho Moon, Sung Jae Park, Chan Guk Park, Sung Jo Bang, Chang Heon Yang, Kyo Sang YooByung Moo Yoo, Kyu Taek Lee, Dong Ki Lee, Byung Seok Lee, Sang Soo Lee, Seung Ok Lee, Woo Jin Lee, Chang Min Cho, Young Eun Joo, Gab Jin Cheon, Young Woo Choi, Jae Bok Chung, Yong Bum Yoon

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Aim: To investigate prevalence Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. Methods: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. Results: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinorna was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. Conclusion: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.

Original languageEnglish
Pages (from-to)86-94
Number of pages9
JournalWorld Journal of Gastroenterology
Volume15
Issue number1
DOIs
Publication statusPublished - 2009 Jan 7

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Clonorchiasis
Gastrointestinal Diseases
Clonorchis sinensis
Cholangiocarcinoma
Korea
Fresh Water
Fishes
Eating
Infection
Cholecystolithiasis
Choledocholithiasis
Cholangitis
Surveys and Questionnaires
Gastroenterology
Pancreatitis
Hepatocellular Carcinoma
Parasites
Epidemiology

Keywords

  • Cholangiocarcinoma
  • Clonorchiasis
  • Clonorchis sinensis
  • Epidemiology
  • Korea
  • Multicenter study

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Prevalence of clonorchiasis in patients with gastrointestinal disease : A Korean nationwide multicenter survey. / Kim, Ho Gak; Han, Jimin; Kim, Myung Hwan; Cho, Kyu Hyun; Shin, Im Hee; Kim, Gwang Ha; Kim, Jae Seon; Kim, Jin Bong; Kim, Tae Nyeun; Kim, Tae Hyeon; Kim, Tae Hyo; Kim, Jae Woo; Ryu, Ji Kon; Moon, Young Soo; Moon, Jong Ho; Park, Sung Jae; Park, Chan Guk; Bang, Sung Jo; Yang, Chang Heon; Yoo, Kyo Sang; Yoo, Byung Moo; Lee, Kyu Taek; Lee, Dong Ki; Lee, Byung Seok; Lee, Sang Soo; Lee, Seung Ok; Lee, Woo Jin; Cho, Chang Min; Joo, Young Eun; Cheon, Gab Jin; Choi, Young Woo; Chung, Jae Bok; Yoon, Yong Bum.

In: World Journal of Gastroenterology, Vol. 15, No. 1, 07.01.2009, p. 86-94.

Research output: Contribution to journalArticle

Kim, HG, Han, J, Kim, MH, Cho, KH, Shin, IH, Kim, GH, Kim, JS, Kim, JB, Kim, TN, Kim, TH, Kim, TH, Kim, JW, Ryu, JK, Moon, YS, Moon, JH, Park, SJ, Park, CG, Bang, SJ, Yang, CH, Yoo, KS, Yoo, BM, Lee, KT, Lee, DK, Lee, BS, Lee, SS, Lee, SO, Lee, WJ, Cho, CM, Joo, YE, Cheon, GJ, Choi, YW, Chung, JB & Yoon, YB 2009, 'Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey', World Journal of Gastroenterology, vol. 15, no. 1, pp. 86-94. https://doi.org/10.3748/wjg.15.86
Kim, Ho Gak ; Han, Jimin ; Kim, Myung Hwan ; Cho, Kyu Hyun ; Shin, Im Hee ; Kim, Gwang Ha ; Kim, Jae Seon ; Kim, Jin Bong ; Kim, Tae Nyeun ; Kim, Tae Hyeon ; Kim, Tae Hyo ; Kim, Jae Woo ; Ryu, Ji Kon ; Moon, Young Soo ; Moon, Jong Ho ; Park, Sung Jae ; Park, Chan Guk ; Bang, Sung Jo ; Yang, Chang Heon ; Yoo, Kyo Sang ; Yoo, Byung Moo ; Lee, Kyu Taek ; Lee, Dong Ki ; Lee, Byung Seok ; Lee, Sang Soo ; Lee, Seung Ok ; Lee, Woo Jin ; Cho, Chang Min ; Joo, Young Eun ; Cheon, Gab Jin ; Choi, Young Woo ; Chung, Jae Bok ; Yoon, Yong Bum. / Prevalence of clonorchiasis in patients with gastrointestinal disease : A Korean nationwide multicenter survey. In: World Journal of Gastroenterology. 2009 ; Vol. 15, No. 1. pp. 86-94.
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abstract = "Aim: To investigate prevalence Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. Methods: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. Results: Of 3080 patients with gastrointestinal diseases, 396 (12.9{\%}) had clonorchiasis and 1140 patients (37.2{\%}) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9{\%}) patients had clonorchiasis. Cholangiocarcinorna was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6{\%}) vs 145/2684 (5.4{\%}), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. Conclusion: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.",
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author = "Kim, {Ho Gak} and Jimin Han and Kim, {Myung Hwan} and Cho, {Kyu Hyun} and Shin, {Im Hee} and Kim, {Gwang Ha} and Kim, {Jae Seon} and Kim, {Jin Bong} and Kim, {Tae Nyeun} and Kim, {Tae Hyeon} and Kim, {Tae Hyo} and Kim, {Jae Woo} and Ryu, {Ji Kon} and Moon, {Young Soo} and Moon, {Jong Ho} and Park, {Sung Jae} and Park, {Chan Guk} and Bang, {Sung Jo} and Yang, {Chang Heon} and Yoo, {Kyo Sang} and Yoo, {Byung Moo} and Lee, {Kyu Taek} and Lee, {Dong Ki} and Lee, {Byung Seok} and Lee, {Sang Soo} and Lee, {Seung Ok} and Lee, {Woo Jin} and Cho, {Chang Min} and Joo, {Young Eun} and Cheon, {Gab Jin} and Choi, {Young Woo} and Chung, {Jae Bok} and Yoon, {Yong Bum}",
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AU - Kim, Ho Gak

AU - Han, Jimin

AU - Kim, Myung Hwan

AU - Cho, Kyu Hyun

AU - Shin, Im Hee

AU - Kim, Gwang Ha

AU - Kim, Jae Seon

AU - Kim, Jin Bong

AU - Kim, Tae Nyeun

AU - Kim, Tae Hyeon

AU - Kim, Tae Hyo

AU - Kim, Jae Woo

AU - Ryu, Ji Kon

AU - Moon, Young Soo

AU - Moon, Jong Ho

AU - Park, Sung Jae

AU - Park, Chan Guk

AU - Bang, Sung Jo

AU - Yang, Chang Heon

AU - Yoo, Kyo Sang

AU - Yoo, Byung Moo

AU - Lee, Kyu Taek

AU - Lee, Dong Ki

AU - Lee, Byung Seok

AU - Lee, Sang Soo

AU - Lee, Seung Ok

AU - Lee, Woo Jin

AU - Cho, Chang Min

AU - Joo, Young Eun

AU - Cheon, Gab Jin

AU - Choi, Young Woo

AU - Chung, Jae Bok

AU - Yoon, Yong Bum

PY - 2009/1/7

Y1 - 2009/1/7

N2 - Aim: To investigate prevalence Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. Methods: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. Results: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinorna was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. Conclusion: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.

AB - Aim: To investigate prevalence Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. Methods: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. Results: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinorna was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. Conclusion: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.

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