Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey

Ho Gak Kim, Jimin Han, Myung Hwan Kim, Kyu Hyun Cho, Im Hee Shin, Gwang Ha Kim, Jae Seon Kim, Jin Bong Kim, Tae Nyeun Kim, Tae Hyeon Kim, Tae Hyo Kim, Jae Woo Kim, Ji Kon Ryu, Young Soo Moon, Jong Ho Moon, Sung Jae Park, Chan Guk Park, Sung Jo Bang, Chang Heon Yang, Kyo Sang YooByung Moo Yoo, Kyu Taek Lee, Dong Ki Lee, Byung Seok Lee, Sang Soo Lee, Seung Ok Lee, Woo Jin Lee, Chang Min Cho, Young Eun Joo, Gab Jin Cheon, Young Woo Choi, Jae Bok Chung, Yong Bum Yoon

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Aim: To investigate prevalence Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea. Methods: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire. Results: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinorna was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis. Conclusion: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite.

Original languageEnglish
Pages (from-to)86-94
Number of pages9
JournalWorld journal of gastroenterology
Volume15
Issue number1
DOIs
Publication statusPublished - 2009 Jan 7

Keywords

  • Cholangiocarcinoma
  • Clonorchiasis
  • Clonorchis sinensis
  • Epidemiology
  • Korea
  • Multicenter study

ASJC Scopus subject areas

  • Gastroenterology

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    Kim, H. G., Han, J., Kim, M. H., Cho, K. H., Shin, I. H., Kim, G. H., Kim, J. S., Kim, J. B., Kim, T. N., Kim, T. H., Kim, T. H., Kim, J. W., Ryu, J. K., Moon, Y. S., Moon, J. H., Park, S. J., Park, C. G., Bang, S. J., Yang, C. H., ... Yoon, Y. B. (2009). Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey. World journal of gastroenterology, 15(1), 86-94. https://doi.org/10.3748/wjg.15.86