Prevalence of metabolic syndrome is higher among non-obese PCOS women with hyperandrogenism and menstrual irregularity in Korea

Min Ju Kim, Nam Kyoo Lim, Young Min Choi, Jin Ju Kim, Kyu Ri Hwang, Soo Jin Chae, Chan Woo Park, Doo Seok Choi, Byung Moon Kang, Byung Seok Lee, Tak Kim, Hyun Young Park

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Hyperandrogenism (HA) has been linked with several components of metabolic syndrome (MetS). Few studies in Asian women have evaluated the important risk factors for and prevalence of MetS according to PCOS subtype. In this study, we investigated differences in metabolic parameters and the prevalence of MetS in two major phenotypic subgroups of PCOS in Korea. Furthermore, we investigated the relationship between HA-associated parameters and MetS. Materials and Methods: This cross-sectional observational study was conducted from May 2010 to December 2011 in Korea. A total of 837 females with PCOS, aged 15-40, were recruited from Departments of Obstetrics and Gynecology at 13 hospitals. Of those, 700 subjects with either polycystic ovaries (PCO)+HA+oligomenorrhea/amenorrhea (O) or PCO+O were eligible for this study. MetS was diagnosed according to the modified National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III guidelines and the International Diabetes Federation (IDF) criteria. Results: MetS was more prevalent in the PCO+HA+O group (19.7%) than in the PCO+O (11.9%) group. There were statistically significant trends for an increased risk of MetS in the PCO+HA+O group compared to the PCO+O group. After adjustment for age, the odds ratio of MetS was 2.192 in non-obese subjects with PCO+HA+O compared to those with PCO+ O, whereas the risk of MetS was not different in obese patients. Multivariate logistic regression analysis showed that high free androgen index and low sex hormone-binding globulin were significantly associated with MetS in non-obese women with PCOS, with odds ratios of 4.234 (95% CI, 1.893-9.474) and 4.612 (95% CI, 1.978-10.750), respectively. However, no associations were detected between MetS and SHBG and FAI in obese PCOS subjects. Conclusions: Our results indicate that HA and its associated parameters (FAI and SHBG) are significantly associated with MetS in non-obese PCOS subjects, whereas this association was not observed in obese subjects. Copyright:

Original languageEnglish
Article numbere99252
JournalPLoS One
Volume9
Issue number6
DOIs
Publication statusPublished - 2014 Jun 5

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Hyperandrogenism
metabolic syndrome
Korea
Korean Peninsula
Ovary
Gynecology
Obstetrics
Sex Hormone-Binding Globulin
Regression analysis
Androgens
Logistics
Education
Cholesterol
odds ratio
hyperandrogenism
Odds Ratio
Oligomenorrhea
amenorrhea
Hospital Obstetrics and Gynecology Department
Polycystic Ovary Syndrome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Kim, M. J., Lim, N. K., Choi, Y. M., Kim, J. J., Hwang, K. R., Chae, S. J., ... Park, H. Y. (2014). Prevalence of metabolic syndrome is higher among non-obese PCOS women with hyperandrogenism and menstrual irregularity in Korea. PLoS One, 9(6), [e99252]. https://doi.org/10.1371/journal.pone.0099252

Prevalence of metabolic syndrome is higher among non-obese PCOS women with hyperandrogenism and menstrual irregularity in Korea. / Kim, Min Ju; Lim, Nam Kyoo; Choi, Young Min; Kim, Jin Ju; Hwang, Kyu Ri; Chae, Soo Jin; Park, Chan Woo; Choi, Doo Seok; Kang, Byung Moon; Lee, Byung Seok; Kim, Tak; Park, Hyun Young.

In: PLoS One, Vol. 9, No. 6, e99252, 05.06.2014.

Research output: Contribution to journalArticle

Kim, MJ, Lim, NK, Choi, YM, Kim, JJ, Hwang, KR, Chae, SJ, Park, CW, Choi, DS, Kang, BM, Lee, BS, Kim, T & Park, HY 2014, 'Prevalence of metabolic syndrome is higher among non-obese PCOS women with hyperandrogenism and menstrual irregularity in Korea', PLoS One, vol. 9, no. 6, e99252. https://doi.org/10.1371/journal.pone.0099252
Kim, Min Ju ; Lim, Nam Kyoo ; Choi, Young Min ; Kim, Jin Ju ; Hwang, Kyu Ri ; Chae, Soo Jin ; Park, Chan Woo ; Choi, Doo Seok ; Kang, Byung Moon ; Lee, Byung Seok ; Kim, Tak ; Park, Hyun Young. / Prevalence of metabolic syndrome is higher among non-obese PCOS women with hyperandrogenism and menstrual irregularity in Korea. In: PLoS One. 2014 ; Vol. 9, No. 6.
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abstract = "Background: Hyperandrogenism (HA) has been linked with several components of metabolic syndrome (MetS). Few studies in Asian women have evaluated the important risk factors for and prevalence of MetS according to PCOS subtype. In this study, we investigated differences in metabolic parameters and the prevalence of MetS in two major phenotypic subgroups of PCOS in Korea. Furthermore, we investigated the relationship between HA-associated parameters and MetS. Materials and Methods: This cross-sectional observational study was conducted from May 2010 to December 2011 in Korea. A total of 837 females with PCOS, aged 15-40, were recruited from Departments of Obstetrics and Gynecology at 13 hospitals. Of those, 700 subjects with either polycystic ovaries (PCO)+HA+oligomenorrhea/amenorrhea (O) or PCO+O were eligible for this study. MetS was diagnosed according to the modified National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III guidelines and the International Diabetes Federation (IDF) criteria. Results: MetS was more prevalent in the PCO+HA+O group (19.7{\%}) than in the PCO+O (11.9{\%}) group. There were statistically significant trends for an increased risk of MetS in the PCO+HA+O group compared to the PCO+O group. After adjustment for age, the odds ratio of MetS was 2.192 in non-obese subjects with PCO+HA+O compared to those with PCO+ O, whereas the risk of MetS was not different in obese patients. Multivariate logistic regression analysis showed that high free androgen index and low sex hormone-binding globulin were significantly associated with MetS in non-obese women with PCOS, with odds ratios of 4.234 (95{\%} CI, 1.893-9.474) and 4.612 (95{\%} CI, 1.978-10.750), respectively. However, no associations were detected between MetS and SHBG and FAI in obese PCOS subjects. Conclusions: Our results indicate that HA and its associated parameters (FAI and SHBG) are significantly associated with MetS in non-obese PCOS subjects, whereas this association was not observed in obese subjects. Copyright:",
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AU - Kim, Jin Ju

AU - Hwang, Kyu Ri

AU - Chae, Soo Jin

AU - Park, Chan Woo

AU - Choi, Doo Seok

AU - Kang, Byung Moon

AU - Lee, Byung Seok

AU - Kim, Tak

AU - Park, Hyun Young

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N2 - Background: Hyperandrogenism (HA) has been linked with several components of metabolic syndrome (MetS). Few studies in Asian women have evaluated the important risk factors for and prevalence of MetS according to PCOS subtype. In this study, we investigated differences in metabolic parameters and the prevalence of MetS in two major phenotypic subgroups of PCOS in Korea. Furthermore, we investigated the relationship between HA-associated parameters and MetS. Materials and Methods: This cross-sectional observational study was conducted from May 2010 to December 2011 in Korea. A total of 837 females with PCOS, aged 15-40, were recruited from Departments of Obstetrics and Gynecology at 13 hospitals. Of those, 700 subjects with either polycystic ovaries (PCO)+HA+oligomenorrhea/amenorrhea (O) or PCO+O were eligible for this study. MetS was diagnosed according to the modified National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III guidelines and the International Diabetes Federation (IDF) criteria. Results: MetS was more prevalent in the PCO+HA+O group (19.7%) than in the PCO+O (11.9%) group. There were statistically significant trends for an increased risk of MetS in the PCO+HA+O group compared to the PCO+O group. After adjustment for age, the odds ratio of MetS was 2.192 in non-obese subjects with PCO+HA+O compared to those with PCO+ O, whereas the risk of MetS was not different in obese patients. Multivariate logistic regression analysis showed that high free androgen index and low sex hormone-binding globulin were significantly associated with MetS in non-obese women with PCOS, with odds ratios of 4.234 (95% CI, 1.893-9.474) and 4.612 (95% CI, 1.978-10.750), respectively. However, no associations were detected between MetS and SHBG and FAI in obese PCOS subjects. Conclusions: Our results indicate that HA and its associated parameters (FAI and SHBG) are significantly associated with MetS in non-obese PCOS subjects, whereas this association was not observed in obese subjects. Copyright:

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