Prevalence of serum IgG antibodies to cystic echinococcus antigen among patients in an Uzbekistan emergency hospital

Se Jin Park, Sung Sik Han, Khikmat Anvarov, Abdukhakim Khajibaev, Min Ho Choi, Sung Tae Hong

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Cystic echinococcosis (CE) is one of the most widespread zoonotic helminthiases, which can last an asymptomatic infection for several years. The purpose of this study was to demonstrate serum antibody prevalence of CE among asymptomatic people in Uzbekistan using ELISA. A total of 2,547 serum samples were collected, 66 from confirmed CE patients and 2,481 of patients with other diseases than CE at a hospital in Tashkent, Uzbekistan. The serum samples were screened for CE specific IgG antibodies by ELISA using cystic fluid antigen obtained from sheep. The serum antibody positive rate was 89.4% (59/66) in CE and 3.6% (89/2,481) in other disease patients. The present ELISA recognized 89.4% sensitivity and 96.4% specificity. The ELISA absorbance of positive samples was distributed 0.2710.971 for CE and 0.273-0.887 for other disease patients. The other disease patients with high absorbance over 0.3 were 50 (2.0%) who were presumed to be active CE patients. The patients in their 40s showed the highest positive rate of 5.2% (P = 0.181), and women were 4.4% while men were 3.1% positive (P = 0.136). The data confirmed that there are many asymptomatic patients of CE in Tashkent. It is indicated that CE is an endemic disease of public health importance in Uzbekistan.

Original languageEnglish
Pages (from-to)699-703
Number of pages5
JournalKorean Journal of Parasitology
Volume53
Issue number6
DOIs
Publication statusPublished - 2015 Dec 1

Fingerprint

Uzbekistan
Echinococcus
Echinococcosis
Emergencies
Immunoglobulin G
Antigens
Antibodies
Serum
Enzyme-Linked Immunosorbent Assay
Helminthiasis
Endemic Diseases
Asymptomatic Infections
Zoonoses
Sheep
Public Health

Keywords

  • Asymptomatic
  • Cystic echinococcosis
  • Echinococcus granulosus
  • ELISA
  • Patient
  • Positive rate
  • Serum antibody
  • Uzbekistan

ASJC Scopus subject areas

  • Infectious Diseases
  • Parasitology

Cite this

Prevalence of serum IgG antibodies to cystic echinococcus antigen among patients in an Uzbekistan emergency hospital. / Park, Se Jin; Han, Sung Sik; Anvarov, Khikmat; Khajibaev, Abdukhakim; Choi, Min Ho; Hong, Sung Tae.

In: Korean Journal of Parasitology, Vol. 53, No. 6, 01.12.2015, p. 699-703.

Research output: Contribution to journalArticle

Park, Se Jin ; Han, Sung Sik ; Anvarov, Khikmat ; Khajibaev, Abdukhakim ; Choi, Min Ho ; Hong, Sung Tae. / Prevalence of serum IgG antibodies to cystic echinococcus antigen among patients in an Uzbekistan emergency hospital. In: Korean Journal of Parasitology. 2015 ; Vol. 53, No. 6. pp. 699-703.
@article{a8e832a47a844a36aa442bee3f06a398,
title = "Prevalence of serum IgG antibodies to cystic echinococcus antigen among patients in an Uzbekistan emergency hospital",
abstract = "Cystic echinococcosis (CE) is one of the most widespread zoonotic helminthiases, which can last an asymptomatic infection for several years. The purpose of this study was to demonstrate serum antibody prevalence of CE among asymptomatic people in Uzbekistan using ELISA. A total of 2,547 serum samples were collected, 66 from confirmed CE patients and 2,481 of patients with other diseases than CE at a hospital in Tashkent, Uzbekistan. The serum samples were screened for CE specific IgG antibodies by ELISA using cystic fluid antigen obtained from sheep. The serum antibody positive rate was 89.4{\%} (59/66) in CE and 3.6{\%} (89/2,481) in other disease patients. The present ELISA recognized 89.4{\%} sensitivity and 96.4{\%} specificity. The ELISA absorbance of positive samples was distributed 0.2710.971 for CE and 0.273-0.887 for other disease patients. The other disease patients with high absorbance over 0.3 were 50 (2.0{\%}) who were presumed to be active CE patients. The patients in their 40s showed the highest positive rate of 5.2{\%} (P = 0.181), and women were 4.4{\%} while men were 3.1{\%} positive (P = 0.136). The data confirmed that there are many asymptomatic patients of CE in Tashkent. It is indicated that CE is an endemic disease of public health importance in Uzbekistan.",
keywords = "Asymptomatic, Cystic echinococcosis, Echinococcus granulosus, ELISA, Patient, Positive rate, Serum antibody, Uzbekistan",
author = "Park, {Se Jin} and Han, {Sung Sik} and Khikmat Anvarov and Abdukhakim Khajibaev and Choi, {Min Ho} and Hong, {Sung Tae}",
year = "2015",
month = "12",
day = "1",
doi = "10.3347/kjp.2015.53.6.699",
language = "English",
volume = "53",
pages = "699--703",
journal = "Korean Journal of Parasitology",
issn = "0023-4001",
publisher = "Korean Journal of Parasitology",
number = "6",

}

TY - JOUR

T1 - Prevalence of serum IgG antibodies to cystic echinococcus antigen among patients in an Uzbekistan emergency hospital

AU - Park, Se Jin

AU - Han, Sung Sik

AU - Anvarov, Khikmat

AU - Khajibaev, Abdukhakim

AU - Choi, Min Ho

AU - Hong, Sung Tae

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Cystic echinococcosis (CE) is one of the most widespread zoonotic helminthiases, which can last an asymptomatic infection for several years. The purpose of this study was to demonstrate serum antibody prevalence of CE among asymptomatic people in Uzbekistan using ELISA. A total of 2,547 serum samples were collected, 66 from confirmed CE patients and 2,481 of patients with other diseases than CE at a hospital in Tashkent, Uzbekistan. The serum samples were screened for CE specific IgG antibodies by ELISA using cystic fluid antigen obtained from sheep. The serum antibody positive rate was 89.4% (59/66) in CE and 3.6% (89/2,481) in other disease patients. The present ELISA recognized 89.4% sensitivity and 96.4% specificity. The ELISA absorbance of positive samples was distributed 0.2710.971 for CE and 0.273-0.887 for other disease patients. The other disease patients with high absorbance over 0.3 were 50 (2.0%) who were presumed to be active CE patients. The patients in their 40s showed the highest positive rate of 5.2% (P = 0.181), and women were 4.4% while men were 3.1% positive (P = 0.136). The data confirmed that there are many asymptomatic patients of CE in Tashkent. It is indicated that CE is an endemic disease of public health importance in Uzbekistan.

AB - Cystic echinococcosis (CE) is one of the most widespread zoonotic helminthiases, which can last an asymptomatic infection for several years. The purpose of this study was to demonstrate serum antibody prevalence of CE among asymptomatic people in Uzbekistan using ELISA. A total of 2,547 serum samples were collected, 66 from confirmed CE patients and 2,481 of patients with other diseases than CE at a hospital in Tashkent, Uzbekistan. The serum samples were screened for CE specific IgG antibodies by ELISA using cystic fluid antigen obtained from sheep. The serum antibody positive rate was 89.4% (59/66) in CE and 3.6% (89/2,481) in other disease patients. The present ELISA recognized 89.4% sensitivity and 96.4% specificity. The ELISA absorbance of positive samples was distributed 0.2710.971 for CE and 0.273-0.887 for other disease patients. The other disease patients with high absorbance over 0.3 were 50 (2.0%) who were presumed to be active CE patients. The patients in their 40s showed the highest positive rate of 5.2% (P = 0.181), and women were 4.4% while men were 3.1% positive (P = 0.136). The data confirmed that there are many asymptomatic patients of CE in Tashkent. It is indicated that CE is an endemic disease of public health importance in Uzbekistan.

KW - Asymptomatic

KW - Cystic echinococcosis

KW - Echinococcus granulosus

KW - ELISA

KW - Patient

KW - Positive rate

KW - Serum antibody

KW - Uzbekistan

UR - http://www.scopus.com/inward/record.url?scp=84953252658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953252658&partnerID=8YFLogxK

U2 - 10.3347/kjp.2015.53.6.699

DO - 10.3347/kjp.2015.53.6.699

M3 - Article

VL - 53

SP - 699

EP - 703

JO - Korean Journal of Parasitology

JF - Korean Journal of Parasitology

SN - 0023-4001

IS - 6

ER -